Prof. dr hab. Katarzyna Starowicz - Bubak
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CB2 agonism controls pain and subchondral bone degeneration induced by mono-iodoacetate: Implications GPCR functional bias and tolerance development.
Jakub Mlost, Magdalena Kostrzewa, Małgorzata Borczyk, Marta Bryk, Jakub Chwastek, Michał Korostyński, Katarzyna Starowicz
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, S0753-3322(21)00068-8 10.1016/j.biopha.2021.111283
PMID:33482616
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Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action.
Jakub Mlost, Marta Bryk, Katarzyna Starowicz
International journal of molecular sciences, E8870 10.3390/ijms21228870
PMID:33238607
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Claudia Mugnaini, Magdalena Kostrzewa, Marta Bryk, Ali Mokhtar Mahmoud, Antonella Brizzi, Stefania Lamponi, Gianluca Giorgi, Francesca Ferlenghi, Federica Vacondio, Paola Maccioni, Giancarlo Colombo, Marco Mor, Katarzyna Starowicz, Vincenzo Di Marzo, Alessia Ligresti, Federico Corelli
Journal of medicinal chemistry, 10.1021/acs.jmedchem.0c00595
PMID:32515588
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Role of endocannabinoid system in dopamine signalling within the reward circuits affected by chronic pain.
Jakub Mlost, Agnieszka Wąsik, Katarzyna Starowicz
Pharmacological research, S1043-6618(19)30008-8 10.1016/j.phrs.2019.02.029
PMID:30831242
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Changes in Monoaminergic Neurotransmission in an Animal Model of Osteoarthritis: The Role of Endocannabinoid Signaling.
Jakub Mlost, Agnieszka Wąsik, Jerzy Tadeusz Michaluk, Lucyna Antkiewicz-Michaluk, Katarzyna Starowicz
Frontiers in molecular neuroscience, 10.3389/fnmol.2018.00466
PMID:30618615
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Joint problems arising from lack of repair mechanisms: can cannabinoids help?
Natalia Malek, Katarzyna Starowicz
British journal of pharmacology, 10.1111/bph.14204
PMID:29574720
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Molecular Understanding of the Activation of CB1 and Blockade of TRPV1 Receptors: Implications for Novel Treatment Strategies in Osteoarthritis.
Jakub Mlost, Magdalena Kostrzewa, Natalia Malek, Katarzyna Starowicz
International journal of molecular sciences, E342 10.3390/ijms19020342
PMID:29364174
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Cell-type-specific gene expression patterns in the knee cartilage in an osteoarthritis rat model.
Michal Korostynski, Natalia Malek, Marcin Piechota, Katarzyna Starowicz
Functional & integrative genomics, 10.1007/s10142-017-0576-6
PMID:29134405
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Cannabinoids and Pain: Sites and Mechanisms of Action.
Katarzyna Starowicz, David P Finn
Advances in pharmacology (San Diego, Calif.), S1054-3589(17)30044-3 10.1016/bs.apha.2017.05.003
PMID:28826543
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Expression of matrix metalloproteinases and components of the endocannabinoid system in the knee joint are associated with biphasic pain progression in a rat model of osteoarthritis.
Agnieszka Pajak, Magdalena Kostrzewa, Natalia Malek, Michal Korostynski, Katarzyna Starowicz
Journal of pain research, 10.2147/JPR.S132682
PMID:28860852
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Blood Transcriptional Signatures for Disease Progression in a Rat Model of Osteoarthritis.
Michał Korostyński, Natalia Małek, Marcin Piechota, Katarzyna Starowicz
International journal of genomics, 10.1155/2017/1746426
PMID:28758108
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Allodynia Lowering Induced by Cannabinoids and Endocannabinoids (ALICE).
Livio Luongo, Katarzyna Starowicz, Sabatino Maione, Vincenzo Di Marzo
Pharmacological research, S1043-6618(17)30153-6 10.1016/j.phrs.2017.02.019
PMID:28237514
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The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain.
Natalia Malek, Magdalena Kostrzewa, Wioletta Makuch, Agnieszka Pajak, Mateusz Kucharczyk, Fabiana Piscitelli, Barbara Przewlocka, Vincenzo Di Marzo, Katarzyna Starowicz
Pharmacological research, 10.1016/j.phrs.2016.06.012 S1043-6618(16)30566-7
PMID:27326920
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Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems-A Novel Treatment Option for Chronic Pain Management.
Natalia Malek, Katarzyna Starowicz
Frontiers in pharmacology, 10.3389/fphar.2016.00257
PMID:27582708
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Anandamide, Acting via CB2 Receptors, Alleviates LPS-Induced Neuroinflammation in Rat Primary Microglial Cultures.
Natalia Malek, Katarzyna Popiolek-Barczyk, Joanna Mika, Barbara Przewlocka, Katarzyna Starowicz
Neural plasticity, 10.1155/2015/130639
PMID:26090232
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A multi-target approach for pain treatment: dual inhibition of fatty acid amide hydrolase and TRPV1 in a rat model of osteoarthritis.
Natalia Malek, Monika Mrugala, Wioletta Makuch, Natalia Kolosowska, Barbara Przewlocka, Marcin Binkowski, Martyna Czaja, Enrico Morera, Vincenzo Di Marzo, Katarzyna Starowicz
Pain, 10.1097/j.pain.0000000000000132
PMID:25719612
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Chronic pain: new insights in molecular and cellular mechanisms.
Livio Luongo, Marzia Malcangio, Daniela Salvemini, Katarzyna Starowicz
BioMed research international, 10.1155/2015/676725
PMID:25879035
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The importance of TRPV1-sensitisation factors for the development of neuropathic pain.
Natalia Malek, Agnieszka Pajak, Natalia Kolosowska, Mateusz Kucharczyk, Katarzyna Starowicz
Molecular and cellular neurosciences, 10.1016/j.mcn.2015.02.001 S1044-7431(15)00012-3
PMID:25662734
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Alterations in the anandamide metabolism in the development of neuropathic pain.
Natalia Malek, Mateusz Kucharczyk, Katarzyna Starowicz
BioMed research international, 10.1155/2014/686908
PMID:25276812
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Delta-opioid receptor analgesia is independent of microglial activation in a rat model of neuropathic pain.
Joanna Mika, Katarzyna Popiolek-Barczyk, Ewelina Rojewska, Wioletta Makuch, Katarzyna Starowicz, Barbara Przewlocka
PloS one, 10.1371/journal.pone.0104420
PMID:25105291
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Non-psychotropic analgesic drugs from the endocannabinoid system:
Katarzyna Starowicz, Vincenzo Di Marzo
European journal of pharmacology, 10.1016/j.ejphar.2013.01.075 S0014-2999(13)00176-3
PMID:23500197
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Full inhibition of spinal FAAH leads to TRPV1-mediated analgesic effects in neuropathic rats and possible lipoxygenase-mediated remodeling of anandamide metabolism.
Katarzyna Starowicz, Wioletta Makuch, Michal Korostynski, Natalia Malek, Michal Slezak, Magdalena Zychowska, Stefania Petrosino, Luciano De Petrocellis, Luigia Cristino, Barbara Przewlocka, Vincenzo Di Marzo
PloS one, 10.1371/journal.pone.0060040
PMID:23573230
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A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neurons.
Luciano De Petrocellis, Aniello Schiano Moriello, Roberta Imperatore, Luigia Cristino, Katarzyna Starowicz, Vincenzo Di Marzo
British journal of pharmacology, 10.1111/j.1476-5381.2012.02122.x
PMID:22861649
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Modulation of neuropathic-pain-related behaviour by the spinal endocannabinoid/endovanilloid system.
Katarzyna Starowicz, Barbara Przewlocka
Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 10.1098/rstb.2011.0392
PMID:23108547
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Spinal anandamide produces analgesia in neuropathic rats: possible CB(1)- and TRPV1-mediated mechanisms.
K Starowicz, W Makuch, M Osikowicz, F Piscitelli, S Petrosino, V Di Marzo, B Przewlocka
Neuropharmacology, 10.1016/j.neuropharm.2011.11.021
PMID:22178705
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Agonist-dependent attenuation of mu-opioid receptor-mediated G-protein activation in the dorsal root ganglia of neuropathic rats.
Ilona Obara, Ozge Gunduz Cinar, Katarzyna Starowicz, Sandor Benyhe, Anna Borsodi, Barbara Przewlocka
Journal of neural transmission (Vienna, Austria : 1996), 10.1007/s00702-010-0382-y
PMID:20213428
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Peripheral antinociceptive effects of MC4 receptor antagonists in a rat model of neuropathic pain - a biochemical and behavioral study.
Katarzyna Starowicz, Shaaban A Mousa, Ilona Obara, Agnieszka Chocyk, Ryszard Przewłocki, Krzysztof Wedzony, Halina Machelska, Barbara Przewłocka
Pharmacological reports : PR,
PMID:20081244
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TRPV1 channels control synaptic plasticity in the developing superior colliculus.
Sabatino Maione, Luigia Cristino, Anna Lucia Migliozzi, Anne L Georgiou, Katarzyna Starowicz, Thomas E Salt, Vincenzo Di Marzo
The Journal of physiology, 10.1113/jphysiol.2009.171900
PMID:19406878
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Functional interaction between TRPV1 and mu-opioid receptors in the descending antinociceptive pathway activates glutamate transmission and induces analgesia.
Sabatino Maione, Katarzyna Starowicz, Luigia Cristino, Francesca Guida, Enza Palazzo, Livio Luongo, Francesca Rossi, Ida Marabese, Vito de Novellis, Vincenzo Di Marzo
Journal of neurophysiology, 10.1152/jn.91225.2008
PMID:19297510
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The analgesic effect of N-arachidonoyl-serotonin, a FAAH inhibitor and TRPV1 receptor antagonist, associated with changes in rostral ventromedial medulla and locus coeruleus cell activity in rats.
Vito de Novellis, Enza Palazzo, Francesca Rossi, Luciano De Petrocellis, Stefania Petrosino, Francesca Guida, Livio Luongo, Annalucia Migliozzi, Luigia Cristino, Ida Marabese, Katarzyna Starowicz, Vincenzo Di Marzo, Sabatino Maione, undefined undefined
Neuropharmacology, 10.1016/j.neuropharm.2008.06.023
PMID:18616956
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Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet.
Katarzyna M Starowicz, Luigia Cristino, Isabel Matias, Raffaele Capasso, Alessandro Racioppi, Angelo A Izzo, Vincenzo Di Marzo
Obesity (Silver Spring, Md.), 10.1038/oby.2007.106
PMID:18239598
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Immunohistochemical localization of anabolic and catabolic enzymes for anandamide and other putative endovanilloids in the hippocampus and cerebellar cortex of the mouse brain.
L Cristino, K Starowicz, L De Petrocellis, J Morishita, N Ueda, V Guglielmotti, V Di Marzo
Neuroscience, 10.1016/j.neuroscience.2007.11.047
PMID:18248904
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New Potential Therapies from Vanilloid Transient Receptor Cation (TRPV) Channels.
Vincenzo Di Marzo, Katarzyna Starowicz
Current pharmaceutical design,
PMID:18220813
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TRPV1 receptors in the central nervous system: potential for previously unforeseen therapeutic applications.
Katarzyna Starowicz, Luigia Cristino, Vincenzo Di Marzo
Current pharmaceutical design,
PMID:18220817
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Tonic endovanilloid facilitation of glutamate release in brainstem descending antinociceptive pathways.
Katarzyna Starowicz, Sabatino Maione, Luigia Cristino, Enza Palazzo, Ida Marabese, Francesca Rossi, Vito de Novellis, Vincenzo Di Marzo
The Journal of neuroscience : the official journal of the Society for Neuroscience,
PMID:18077685
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Mechanisms for the coupling of cannabinoid receptors to intracellular calcium mobilization in rat insulinoma beta-cells.
Luciano De Petrocellis, Pietro Marini, Isabel Matias, Aniello Schiano Moriello, Katarzyna Starowicz, Luigia Cristino, Santosh Nigam, Vincenzo Di Marzo
Experimental cell research,
PMID:17585904
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Periaqueductal gray metabotropic glutamate receptor subtype 7 and 8 mediate opposite effects on amino acid release, rostral ventromedial medulla cell activities, and thermal nociception.
Ida Marabese, Francesca Rossi, Enza Palazzo, Vito de Novellis, Katarzyna Starowicz, Luigia Cristino, Daniela Vita, Luisa Gatta, Francesca Guida, Vincenzo Di Marzo, Francesco Rossi, Sabatino Maione
Journal of neurophysiology,
PMID:17507496
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Arvanil, anandamide and N-arachidonoyl-dopamine (NADA) inhibit emesis through cannabinoid CB1 and vanilloid TRPV1 receptors in the ferret.
K A Sharkey, L Cristino, L D Oland, M D Van Sickle, K Starowicz, Q J Pittman, V Guglielmotti, J S Davison, V Di Marzo
The European journal of neuroscience,
PMID:17459108
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Attenuation of allergic contact dermatitis through the endocannabinoid system.
Meliha Karsak, Evelyn Gaffal, Rahul Date, Lihua Wang-Eckhardt, Jennifer Rehnelt, Stefania Petrosino, Katarzyna Starowicz, Regina Steuder, Eberhard Schlicker, Benjamin Cravatt, Raphael Mechoulam, Reinhard Buettner, Sabine Werner, Vincenzo Di Marzo, Thomas Tüting, Andreas Zimmer
Science (New York, N.Y.),
PMID:17556587
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Regulation of transient receptor potential channels of melastatin type 8 (TRPM8): effect of cAMP, cannabinoid CB(1) receptors and endovanilloids.
Luciano De Petrocellis, Katarzyna Starowicz, Aniello Schiano Moriello, Marta Vivese, Pierangelo Orlando, Vincenzo Di Marzo
Experimental cell research,
PMID:17428469
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Biochemistry and pharmacology of endovanilloids.
Katarzyna Starowicz, Santosh Nigam, Vincenzo Di Marzo
Pharmacology & therapeutics,
PMID:17349697
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Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma.
Alessia Ligresti, Aniello Schiano Moriello, Katarzyna Starowicz, Isabel Matias, Simona Pisanti, Luciano De Petrocellis, Chiara Laezza, Giuseppe Portella, Maurizio Bifulco, Vincenzo Di Marzo
The Journal of pharmacology and experimental therapeutics,
PMID:16728591
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Inhibition of morphine tolerance by spinal melanocortin receptor blockade.
Katarzyna Starowicz, Ilona Obara, Ryszard Przewłocki, Barbara Przewlocka
Pain,
PMID:16153779
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Morphine-induced changes in the activity of proopiomelanocortin and prodynorphin systems in zymosan-induced peritonitis in mice.
M Chadzinska, K Starowicz, A Scislowska-Czarnecka, W Bilecki, K Pierzchala-Koziec, R Przewlocki, B Przewlocka, B Plytycz
Immunology letters,
PMID:15979727
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Melanocortin 4 receptor is expressed in the dorsal root ganglions and down-regulated in neuropathic rats.
Katarzyna Starowicz, Wiktor Bilecki, Agnieszka Sieja, Barbara Przewlocka, Ryszard Przewlocki
Neuroscience letters,
PMID:15026153
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The effect of morphine on MC4 and CRF receptor mRNAs in the rat amygdala and attenuation of tolerance after their blockade.
Katarzyna Starowicz, Agnieszka Sieja, Wiktor Bilecki, Ilona Obara, Barbara Przewlocka
Brain research,
PMID:14568335
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The role of melanocortins and their receptors in inflammatory processes, nerve regeneration and nociception.
Katarzyna Starowicz, Barbara Przewłocka
Life sciences,
PMID:12798410
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Modulation of melanocortin-induced changes in spinal nociception by mu-opioid receptor agonist and antagonist in neuropathic rats.
Katarzyna Starowicz, Ryszard Przewlocki, Willem Hendrik Gispen, Barbara Przewlocka
Neuroreport,
PMID:12499847
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Knockdown of spinal opioid receptors by antisense targeting beta-arrestin reduces morphine tolerance and allodynia in rat.
Barbara Przewlocka, Agnieszka Sieja, Katarzyna Starowicz, Marcin Maj, Wiktor Bilecki, Ryszard Przewlocki
Neuroscience letters,
PMID:12044633
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Alterations in Anandamide Synthesis and Degradation during Osteoarthritis Progression in an Animal Model.
Marta Bryk, Jakub Chwastek, Magdalena Kostrzewa, Jakub Mlost, Aleksandra Pędracka, Katarzyna Starowicz
,
PMID:33036283
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Sodium Monoiodoacetate Dose-Dependent Changes in Matrix Metalloproteinases and Inflammatory Components as Prognostic Factors for the Progression of Osteoarthritis.
Marta Bryk, Jakub Chwastek, Jakub Mlost, Magdalena Kostrzewa, Katarzyna Starowicz
,
PMID:33995052
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Mesenchymal stem cells and extracellular vesicles for the treatment of pain: Current status and perspectives.
Marta Bryk, Elżbieta Karnas, Jakub Mlost, Ewa Zuba-Surma, Katarzyna Starowicz
,
PMID:34028798
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Marta Bryk, Katarzyna Starowicz
,
PMID:34050525
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Computational Approach Reveals Pronociceptive Potential of Cannabidiol in Osteoarthritis: Role of Transient Receptor Potential Channels.
Jakub Mlost, Marta Kędziora, Katarzyna Starowicz
,
PMID:34681188
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Antinociceptive and chondroprotective effects of prolonged β-caryophyllene treatment in the animal model of osteoarthritis: Focus on tolerance development.
Jakub Mlost, Przemysław Kac, Marta Kędziora, Katarzyna Starowicz
,
PMID:34856202
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We're living much longer, but are we healthier?
Katarzyna Starowicz, Małgorzata Filip
,
PMID:35876149
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Inflammation-Driven Secretion Potential Is Upregulated in Osteoarthritic Fibroblast-Like Synoviocytes.
Jakub Chwastek, Marta Kędziora, Małgorzata Borczyk, Michał Korostyński, Katarzyna Starowicz
,
PMID:36233118
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The Impact of JWH-133 on Articular Cartilage Regeneration in Osteoarthritis Via Metalloproteinase 13-Dependent Mechanism.
Natalia Malek, Julia Borowczyk, Magdalena Kostrzewa, Agnieszka Pawlowska, Justyna Drukala, Katarzyna Starowicz
,
PMID:36318796
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Marta Kędziora, Serena Boccella, Ida Marabese, Jakub Mlost, Rosmara Infantino, Sabatino Maione, Katarzyna Starowicz
,
PMID:36341807
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Ewelina Honkisz-Orzechowska, Katarzyna Popiołek-Barczyk, Zuzanna Linart, Jadwiga Filipek-Gorzała, Anna Rudnicka, Agata Siwek, Tobias Werner, Holger Stark, Jakub Chwastek, Katarzyna Starowicz, Katarzyna Kieć-Kononowicz, Dorota Łażewska
,
PMID:36370200
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Editorial: Cannabinoids in neuroinflammation, neurodegeneration and pain: Focus on non-neuronal cells.
Haley A Vecchiarelli, Valerie Joers, Malú Gámez Tansey, Katarzyna Starowicz
,
PMID:36605549
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Description of Novel Molecular Factors in Lumbar DRGs and Spinal Cord Factors Underlying Development of Neuropathic Pain Component in the Animal Model of Osteoarthritis.
Natalia Malek, Jakub Mlost, Magdalena Kostrzewa, Jolanta Rajca, Katarzyna Starowicz
,
PMID:37731080
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Jakub Chwastek, Marta Kędziora, Małgorzata Borczyk, Michał Korostyński, Katarzyna Starowicz
,
PMID:37996245
Wszystkie publikacje
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Zaburzenia funkcji poznawczych w bólu przewlekłym – niedoceniane znaczenie CBD. - 2022-08-10 - 2026-08-09
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Rola endokanabinoidów w mechanizmie kontroli motywacji wrażliwym na procesy zapalne - 2021-07-08 - 2021-07-07
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Opracowanie zoptymalizowanych metod leczenia uszkodzeń tkankowych w oparciu o innowacyjne kompozyty oraz mezenchymalne komórki macierzyste i ich pochodne u pacjentów z chorobami cywilizacyjnymi (akronim: BioMiStem) - 2018-07-20 - 2019-12-20
STRATEGMED NCBiRkierownik grantu dr hab. Ewa Zuba-Surma, Uniwersytet Jagielloński (lider), Akademia Górniczo-Hutnicza im. Stanisława Staszica w Krakowie, Instytut Technologii Materiałów Elektronicznych w Warszawie, Uniwersytet Medyczny w Lublinie, Instytut Farmakologii PAN w Krakowie, Instytut Zootechniki - Państwowy Instytut Badawczy w Krakowie oraz Galen-Ortopedia Sp. z o.o
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Znaczenie aktywności synowiocytów błony maziowej w bólu związanym z chorobą zwyrodnieniową stawów - 2017-08-03 - 2018-08-02
OPUS NCN
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Określenie roli rdzeniowych receptorów waniloidowych i ich endogennych ligandów w farmakologii i terapii bólu neuropatycznego
MNiSW
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The role of spinal TRPV1 vanilloid receptors in the analgesic effects of anandamide in a model of neuropathic pain
HOMING FNP
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Interakcja pomiędzy endokanabinoidami i endowaniloidami jako nowy cel terapeutyczny w bólu neuropatycznym
LIDER NCBiR
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Poszukiwanie farmakoterapii choroby zwyrodnieniowej stawów (OA): receptory TRPV1 i CB1 i ich endogenne ligandy jako nowe cele interwencji farmakologicznej”
SONATA BIS NCN
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Rola obwodowych receptorów kanabinoidowych CB2 w terapii choroby zwyrodnieniowej stawów
OPUS NCN
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Nagroda Narodowego Centrum Nauki za osiągnięcia w zakresie badań podstawowych w obszarze nauk o życiu
2016-10-12
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Stypendium habilitacyjne L’Oréal Polska dla Kobiet i Nauki
2012-11-22
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Stypendium START Fundacji na Rzecz Nauki Polskiej
2005-03-08
Krajowa
- Laboratorium mikrotomografii, Zakład Komputerowych Systemów Biomedycznych, Uniwersytet Śląski http://prac.us.edu.pl/~xm/?page_id=2
- Zakład Biologii Komórki, Wydział Biochemii Biofizyki i Biotechnologii, Uniwersytet Jagielloński http://www.zbk.wbbib.uj.edu.pl/pl_PL
Międzynarodowa
- Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University
- Endocannabinoid Research Group (ERG) http://srva.na.icb.cnr.it/erg/
- School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen
