Prof. dr hab. Irena Nalepa
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The Protective Effect of Repeated 1MeTIQ Administration on the Lactacystin-Induced Impairment of Dopamine Release and Decline in TH Level in the Rat Brain.
Agnieszka Wąsik, Irena Romańska, Agnieszka Zelek-Molik, Irena Nalepa, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-018-9939-6
PMID:30129004
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Involvement of Macrophage Inflammatory Protein-1 Family Members in the Development of Diabetic Neuropathy and Their Contribution to Effectiveness of Morphine.
Ewelina Rojewska, Magdalena Zychowska, Anna Piotrowska, Grzegorz Kreiner, Irena Nalepa, Joanna Mika
Frontiers in immunology, 10.3389/fimmu.2018.00494
PMID:29593735
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Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects.
Paweł Zajdel, Tomasz Kos, Krzysztof Marciniec, Grzegorz Satała, Vittorio Canale, Krzysztof Kamiński, Małgorzata Hołuj, Tomasz Lenda, Robert Koralewski, Marek Bednarski, Leszek Nowiński, Jacek Wójcikowski, Władysława A Daniel, Agnieszka Nikiforuk, Irena Nalepa, Piotr Chmielarz, Justyna Kuśmierczyk, Andrzej J Bojarski, Piotr Popik
European journal of medicinal chemistry, S0223-5234(18)30002-3 10.1016/j.ejmech.2018.01.002
PMID:29407591
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Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test.
Katarzyna Rafa-Zabłocka, Grzegorz Kreiner, Monika Bagińska, Justyna Kuśmierczyk, Rosanna Parlato, Irena Nalepa
Scientific reports, 10.1038/s41598-017-14069-6
PMID:29044198
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Spinal CCL1/CCR8 signaling interplay as a potential therapeutic target - Evidence from a mouse diabetic neuropathy model.
Magdalena Zychowska, Ewelina Rojewska, Anna Piotrowska, Grzegorz Kreiner, Irena Nalepa, Joanna Mika
International immunopharmacology, S1567-5769(17)30360-0 10.1016/j.intimp.2017.09.021
PMID:28961489
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Assessment of leukocyte activity in mice devoid of the glucocorticoid receptor in the noradrenergic system (GRDBHCre).
Adam Roman, Justyna Kuśmierczyk, Grzegorz Kreiner, Irena Nalepa
Immunobiology, S0171-2985(17)30163-8 10.1016/j.imbio.2017.10.022
PMID:29030008
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Dicer and microRNAs protect adult dopamine neurons.
Piotr Chmielarz, Julia Konovalova, Syeda Sadia Najam, Heike Alter, Timo Petteri Piepponen, Holger Erfle, Kai C Sonntag, Günther Schütz, Ilya A Vinnikov, Andrii Domanskyi
Cell death & disease, 10.1038/cddis.2017.214
PMID:28542144
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Suppression of pro-inflammatory cytokine expression and lack of anti-depressant-like effect of fluoxetine in lipopolysaccharide-treated old female mice.
Weronika Duda, Marta Kubera, Grzegorz Kreiner, Katarzyna Curzytek, Jan Detka, Katarzyna Głombik, Joanna Ślusarczyk, Agnieszka Basta-Kaim, Bogusława Budziszewska, Władysław Lasoń, Magdalena Regulska, Monika Leśkiewicz, Adam Roman, Agnieszka Zelek-Molik, Irena Nalepa
International immunopharmacology, S1567-5769(17)30155-8 10.1016/j.intimp.2017.04.021
PMID:28460354
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Lack of riluzole efficacy in the progression of the neurodegenerative phenotype in a new conditional mouse model of striatal degeneration.
Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Piotr Chmielarz, Monika Bagińska, Irena Nalepa
PeerJ, 10.7717/peerj.3240
PMID:28462043
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Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling.
Malgorzata Kajta, Agnieszka Wnuk, Joanna Rzemieniec, Ewa Litwa, Wladyslaw Lason, Agnieszka Zelek-Molik, Irena Nalepa, Zofia Rogóż, Adam Grochowalski, Anna K Wojtowicz
The Journal of steroid biochemistry and molecular biology, S0960-0760(17)30066-3 10.1016/j.jsbmb.2017.03.001
PMID:28263910
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A lack of α1A-adrenergic receptor-mediated antidepressant-like effects of S-(+)-niguldipine and B8805-033 in the forced swim test.
Grzegorz Kreiner, Adam Roman, Agnieszka Zelek-Molik, Marta Kowalska, Irena Nalepa
Behavioural pharmacology, 10.1097/FBP.0000000000000204
PMID:26588212
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Erratum to: Neuroprotective Effect of the Endogenous Amine 1MeTIQ in an Animal Model of Parkinson's Disease.
Agnieszka Wasik, Irena Romańska, Jerzy Michaluk, Agnieszka Zelek-Molik, Irena Nalepa, Lucyna Antkiewicz-Michaluk
Neurotoxicity research,
PMID:27106849
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Depressive-like immobility behavior and genotype × stress interactions in male mice of selected strains.
Piotr Chmielarz, Grzegorz Kreiner, Justyna Kuśmierczyk, Marta Kowalska, Adam Roman, Katarzyna Tota, Irena Nalepa
Stress (Amsterdam, Netherlands), 10.3109/10253890.2016.1150995
PMID:26941077
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Neuroprotective Effect of the Endogenous Amine 1MeTIQ in an Animal Model of Parkinson's Disease.
Agnieszka Wąsik, Irena Romańska, Jerzy Michaluk, Agnieszka Zelek-Molik, Irena Nalepa, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-015-9556-6
PMID:26303030
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Imipramine administration induces changes in the phosphorylation of FAK and PYK2 and modulates signaling pathways related to their activity.
Teresa Zalewska, Adam Bielawski, Luiza Stanaszek, Krzysztof Wieczerzak, Małgorzata Ziemka-Nałęcz, Irena Nalepa
Biochimica et biophysica acta, 10.1016/j.bbagen.2015.11.008 S0304-4165(15)00325-6
PMID:26620976
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Selective ablation of glucocorticoid receptors in the noradrenergic system affects evening corticosterone levels in a sex-dependent manner.
Piotr Chmielarz, Grzegorz Kreiner, Irena Nalepa
Pharmacological reports : PR, 10.1016/j.pharep.2015.05.013 S1734-1140(15)00100-0
PMID:26481542
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Disruption of glucocorticoid receptors in the noradrenergic system leads to BDNF up-regulation and altered serotonergic transmission associated with a depressive-like phenotype in female GR(DBHCre) mice.
Piotr Chmielarz, Grzegorz Kreiner, Marta Kot, Agnieszka Zelek-Molik, Marta Kowalska, Monika Bagińska, Władysława Anna Daniel, Irena Nalepa
Pharmacology, biochemistry, and behavior, 10.1016/j.pbb.2015.08.001 S0091-3057(15)30038-1
PMID:26261018
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Prenatal stress affects insulin-like growth factor-1 (IGF-1) level and IGF-1 receptor phosphorylation in the brain of adult rats.
Agnieszka Basta-Kaim, Ewa Szczesny, Katarzyna Glombik, Katarzyna Stachowicz, Joanna Slusarczyk, Irena Nalepa, Agnieszka Zelek-Molik, Katarzyna Rafa-Zablocka, Boguslawa Budziszewska, Marta Kubera, Monika Leskiewicz, Wladyslaw Lason
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 10.1016/j.euroneuro.2014.07.002 S0924-977X(14)00199-0
PMID:25106693
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Isomer-nonspecific action of dichlorodiphenyltrichloroethane on aryl hydrocarbon receptor and G-protein-coupled receptor 30 intracellular signaling in apoptotic neuronal cells.
M Kajta, E Litwa, J Rzemieniec, A Wnuk, W Lason, A Zelek-Molik, I Nalepa, M Grzegorzewska-Hiczwa, K Tokarski, A Golas, E Guzik, A Grochowalski, K A Szychowski, A K Wojtowicz
Molecular and cellular endocrinology, 10.1016/j.mce.2014.05.008 S0303-7207(14)00150-6
PMID:24859647
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α1-Adrenergic receptor subtypes in the central nervous system: insights from genetically engineered mouse models.
Irena Nalepa, Grzegorz Kreiner, Adam Bielawski, Katarzyna Rafa-Zabłocka, Adam Roman
Pharmacological reports : PR,
PMID:24552996
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Gender differences in genetic mouse models evaluated for depressive-like and antidepressant behavior.
Grzegorz Kreiner, Piotr Chmielarz, Adam Roman, Irena Nalepa
Pharmacological reports : PR,
PMID:24553006
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Macrophages and depression - a misalliance or well-arranged marriage?
Adam Roman, Grzegorz Kreiner, Irena Nalepa
Pharmacological reports : PR,
PMID:24553015
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Gender-dependent activity of CYP3A is indirectly modified by GR in the noradrenergic system.
Marta Kot, Grzegorz Kreiner, Piotr Chmielarz, Justyna Kuśmierczyk, Irena Nalepa, Władysława A Daniel
Pharmacological reports : PR,
PMID:24399741
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Brief maternal separation affects brain α1-adrenoceptors and apoptotic signaling in adult mice.
Roberto Coccurello, Adam Bielawski, Agnieszka Zelek-Molik, Jerzy Vetulani, Marta Kowalska, Francesca R D'Amato, Irena Nalepa
Progress in neuro-psychopharmacology & biological psychiatry, 10.1016/j.pnpbp.2013.10.004 S0278-5846(13)00220-0
PMID:24128685
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Minocycline influences the anti-inflammatory interleukins and enhances the effectiveness of morphine under mice diabetic neuropathy.
Magdalena Zychowska, Ewelina Rojewska, Grzegorz Kreiner, Irena Nalepa, Barbara Przewlocka, Joanna Mika
Journal of neuroimmunology, 10.1016/j.jneuroim.2013.06.005 S0165-5728(13)00164-1
PMID:23870534
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Inactivation of glucocorticoid receptor in noradrenergic system influences anxiety- and depressive-like behavior in mice.
Piotr Chmielarz, Justyna Kuśmierczyk, Rosanna Parlato, Günther Schütz, Irena Nalepa, Grzegorz Kreiner
PloS one, 10.1371/journal.pone.0072632
PMID:23977333
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Effects of co-administration of fluoxetine and risperidone on properties of peritoneal and pleural macrophages in rats subjected to the forced swimming test.
Adam Roman, Justyna Kuśmierczyk, Ewa Klimek, Zofia Rogóż, Irena Nalepa
Pharmacological reports : PR,
PMID:23406747
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Acute and repeated treatment with the 5-HT7 receptor antagonist SB 269970 induces functional desensitization of 5-HT7 receptors in rat hippocampus.
Krzysztof Tokarski, Agnieszka Zelek-Molik, Beata Duszyńska, Grzegorz Satała, Bartosz Bobula, Magdalena Kusek, Piotr Chmielarz, Irena Nalepa, Grzegorz Hess
Pharmacological reports : PR,
PMID:22661174
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Morphine-induced place preference affects mRNA expression of G protein α subunits in rat brain.
Agnieszka Zelek-Molik, Adam Bielawski, Grzegorz Kreiner, Piotr Popik, Jerzy Vetulani, Irena Nalepa
Pharmacological reports : PR,
PMID:22814008
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Effects of the noradrenergic neurotoxin DSP-4 on the expression of α1-adrenoceptor subtypes after antidepressant treatment.
Grzegorz Kreiner, Agnieszka Zelek-Molik, Marta Kowalska, Adam Bielawski, Lucyna Antkiewicz-Michaluk, Irena Nalepa
Pharmacological reports : PR,
PMID:22358083
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Effects of morphine and methadone treatment on mRNA expression of Gα(i) subunits in rat brains.
Agnieszka Zelek-Molik, Ewa Taracha, Dominika Nawrat, Adam Bielawski, Małgorzata Lehner, Adam Płaźnik, Irena Nalepa
Pharmacological reports : PR,
PMID:21273678
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Paroxetine pretreatment does not change the effects induced in the rat cortical beta-adrenergic receptor system by repetitive transcranial magnetic stimulation and electroconvulsive shock.
Jerzy Vetulani, Adam Roman, Marta Kowalska, Irena Nalepa
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 10.1017/S1461145709990459
PMID:19698191
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Changes induced by formalin pain in central alpha1-adrenoceptor density are modulated by adenosine receptor agonists.
Irena Nalepa, Jerzy Vetulani, Valentina Borghi, Marta Kowalska, Barbara Przewłocka, Adam Roman, Flaminia Pavone
Journal of neural transmission (Vienna, Austria : 1996), 10.1007/s00702-010-0387-6
PMID:20309590
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Concomitant administration of fluoxetine and amantadine modulates the activity of peritoneal macrophages of rats subjected to a forced swimming test.
Adam Roman, Zofia Rogóz, Marta Kubera, Dominika Nawrat, Irena Nalepa
Pharmacological reports : PR,
PMID:20081242
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Effect of cocaine on responsiveness of alpha(1)-adrenergic receptors in rat cerebral cortex: modulation by GABA-mimetic drugs.
Krzysztof Wieczerzak, Tadeusz Witarski, Marta Kowalska, Dominika Nawrat, Adam Roman, Adam Bielawski, Irena Nalepa
Pharmacological reports : PR,
PMID:19211992
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Chronic treatment with electroconvulsive shock may modulate the immune function of macrophages.
Adam Roman, Dominika Nawrat, Irena Nalepa
The journal of ECT, 10.1097/YCT.0b013e31816726ae
PMID:18580695
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Cryptic peptide derived from the rat neuropeptide FF precursor affects G-proteins linked to opioid receptors in the rat brain.
Piotr Suder, Dominika Nawrat, Adam Bielawski, Agnieszka Zelek-Molik, Hana Raoof, Tomasz Dylag, Jolanta Kotlinska, Irena Nalepa, Jerzy Silberring
Peptides, 10.1016/j.peptides.2008.07.012
PMID:18706462
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Does the presence of morphine counteract adaptive changes in expression of G-protein alpha subunits mRNA induced by chronic morphine treatment?
Irena Nalepa, Agnieszka Zelek-Molik, Adam Bielawski, Adam Roman, Jerzy Vetulani
Pharmacological reports : PR,
PMID:17377204
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Effect of cocaine sensitization on alpha1-adrenoceptors in brain regions of the rat: an autoradiographic analysis.
Irena Nalepa, Tadeusz Witarski, Marta Kowalska, Małgorzata Filip, Jerzy Vetulani
Pharmacological reports : PR,
PMID:17220540
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Nicotine potentiates imipramine-induced effects on catecholamine metabolism: possible relation to antidepressant activity.
Lucyna Antkiewicz-Michaluk, Jerzy Michaluk, Irena Romańska, Piotr Popik, Martyna Krawczyk, Irena Nalepa, Jerzy Vetulani
Pharmacological reports : PR,
PMID:17220541
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Formalin hindpaw injection induces changes in the [3H]prazosin binding to alpha1-adrenoceptors in specific regions of the mouse brain and spinal cord.
I Nalepa, J Vetulani, V Borghi, M Kowalska, B Przewłocka, F Pavone
Journal of neural transmission (Vienna, Austria : 1996),
PMID:15719155
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Nicotine produces antidepressant-like actions: Behavioral and neurochemical evidence.
Piotr Popik, Martyna Krawczyk, Tomasz Kos, Irena Nalepa, Marta Kowalska, Tadeusz Witarski, Lucyna Antkiewicz-Michaluk, Jerzy Vetulani
European journal of pharmacology,
PMID:15893747
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Effect of repeated administration of paroxetine and electroconvulsive shock on the proliferative response of lymphocytes and the synthesis of nitric oxide by macrophages in rats.
Adam Roman, Irena Nalepa
The journal of ECT,
PMID:15905754
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Magnetic field inhibits isolated lymphocytes' proliferative response to mitogen stimulation.
Adam Roman, Tomasz Zyss, Irena Nalepa
Bioelectromagnetics,
PMID:15768428
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Chronic treatment with citalopram does not affect the expression of alpha1-adrenergic receptor (alpha1-AR) subtypes.
Grzegorz Kreiner, Adam Bielawski, Agnieszka Zelek-Molik, Marta Kowalska, Irena Nalepa
Polish journal of pharmacology,
PMID:15662097
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The dopamine D4 receptor VNTR in Polish schizophrenia patients.
Marek Sanak, Agnieszka Zelek-Molik, Irena Nalepa, Jacek Wegrzyn, Jacek Wciorka
Schizophrenia research,
PMID:15567085
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Carane derivative stereoisomers of different local anaesthetic and antiplatelet activity similarly potentiate forskolin-stimulated cyclic AMP response and bind to beta-adrenoceptors in the rat brain cortex.
Tadeusz Librowski, Jerzy Vetulani, Irena Nalepa
The Journal of pharmacy and pharmacology,
PMID:15525450
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The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice.
J Vetulani, F Pavone, B Przewłocka, V Borghi, I Nalepa
Journal of neural transmission (Vienna, Austria : 1996),
PMID:14628186
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Behavioural and biochemical studies of citalopram and WAY 100635 in rat chronic mild stress model.
Mariusz Papp, Irena Nalepa, Lucyna Antkiewicz-Michaluk, Connie Sánchez
Pharmacology, biochemistry, and behavior,
PMID:11900821
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Effect of combined treatment with paroxetine and transcranial magnetic stimulation (TMS) on the mitogen-induced proliferative response of rat lymphocytes.
Adam Roman, Jerzy Vetulani, Irena Nalepa
Polish journal of pharmacology,
PMID:12866718
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A possible physiological role for cerebral tetrahydroisoquinolines.
Jerzy Vetulani, Lucyna Antkiewicz-Michaluk, Irena Nalepa, Mario Sansone
Neurotoxicity research,
PMID:12832229
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Modulation by cationic amphiphilic drugs of serine base-exchange, phosholipase d and intracellular calcium homeostasis in glioma C6 cells.
Marta Bobeszko, Rafał Czajkowski, Magdalena Wójcik, Paweł Sabała, Lingsheng Lei, Irena Nalepa, Jolanta Barańska
Polish journal of pharmacology,
PMID:12593535
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Using reverse transcription and a competitive polymerase chain reaction for quantification of alpha1B-adrenoceptor mRNA.
Grzegorz Kreiner, Marek Sanak, Agnieszka Zelek-Molik, Irena Nalepa
Polish journal of pharmacology,
PMID:12523494
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Repeated imipramine and electroconvulsive shock increase alpha 1A-adrenoceptor mRNA level in rat prefrontal cortex.
Irena Nalepa, Grzegorz Kreiner, Marta Kowalska, Marek Sanak, Agnieszka Zelek-Molik, Jerzy Vetulani
European journal of pharmacology,
PMID:12063075
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Opposite effect of simple tetrahydroisoquinolines on amphetamine- and morphine-stimulated locomotor activity in mice.
J Vetulani, I Nalepa, L Antkiewicz-Michaluk, M Sansone
Journal of neural transmission (Vienna, Austria : 1996),
PMID:11459073
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Antidepressants: past, present and future.
J Vetulani, I Nalepa
European journal of pharmacology,
PMID:11033340
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Different regulation of phospholipase D activity in glioma C6 cells by sphingosine, propranolol, imipramine and phorbol ester.
M Bobeszko, A Dygas, I Nalepa, J Barańska
Cellular signalling,
PMID:10889469
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Splenectomy and adoptive cell transfer reveal a prominent role for splenic memory lymphocytes in the development of chronic relapsing experimental autoimmune encephalomyelitis.
J Yang, M Kubera, A Zelek-Molik, I Nalepa, V Hukkanen, P J Lindsberg, S Meri, R Seljelid
Scandinavian journal of immunology,
PMID:11013006
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Haloperidol treatment selectively affects expression of Galpha(i)3 subunit mRNA in specific regions of the rat brain.
M Sanak, G Kreiner, M Kowalska, I Nalepa, J Vetulani
Polish journal of pharmacology,
PMID:10817531
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Adrenergic receptors' responsiveness after acute and chronic treatment with haloperidol in the presence of calcium channel blockade.
I Nalepa, G Kreiner, M Kowalska, M Sanak, J Vetulani
Polish journal of pharmacology,
PMID:10817537
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Lack of beta adrenoceptor desensitization in brain following the dual noradrenaline and serotonin reuptake inhibitor venlafaxine.
I Nalepa, D H Manier, D D Gillespie, S P Rossby, D E Schmidt, F Sulser
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology,
PMID:9716317
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Does Ca2+ channel blockade modulate the antidepressant-induced changes in mechanisms of adrenergic transduction?
I Nalepa, M Kowalska, G Kreiner, J Vetulani
Journal of neural transmission (Vienna, Austria : 1996),
PMID:9295184
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Modulation of electroconvulsive treatment induced beta-adrenergic down-regulation by previous chronic imipramine administration: the involvement of protein kinase C.
I Nalepa, J Vetulani
Polish journal of pharmacology,
PMID:9112690
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The effect of chronic administration of amitriptyline on the effects of subsequent electroconvulsive treatment on responsiveness of alpha 1-and beta-adrenoceptors in the rat cortical slices.
J Vetulani, I Nalepa
Journal of neural transmission (Vienna, Austria : 1996),
PMID:8739848
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Norepinephrine-independent regulation of GRII mRNA in vivo by a tricyclic antidepressant.
S P Rossby, I Nalepa, M Huang, C Perrin, A M Burt, D E Schmidt, D D Gillespie, F Sulser
Brain research,
PMID:7583316
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Altered modulation by excitatory amino acids of cortical phosphatidylinositol system stimulated by carbachol in rats poisoned by an anti-cholinesterase compound, diisopropyl fluorophosphate.
S Fortuna, A Pintor, I Nalepa, H Michalek
Neurotoxicology,
PMID:7854614
-
Reversal by imipramine of beta-adrenoceptor up-regulation induced in a chronic mild stress model of depression.
M Papp, I Nalepa, J Vetulani
European journal of pharmacology,
PMID:8001636
-
The effect of psychotropic drugs on the interaction of protein kinase C with second messenger systems in the rat cerebral cortex.
I Nalepa
Polish journal of pharmacology,
PMID:7981766
-
The effect of (-)-4-(2-hydroxy-3(N-isopropylamino)-propoxyimino)-cis-carane on basal and forskolin-stimulated accumulation of cyclic AMP in the cerebral cortical slices of the rat.
T Librowski, I Nalepa, R Czarnecki, J Vetulani
The Journal of pharmacy and pharmacology,
PMID:8083817
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The antagonistic effect of separate and consecutive chronic treatment with imipramine and ECS on the inhibition of alpha 1-adrenoceptor activity by protein kinase C.
I Nalepa, E Chalecka-Franaszek, J Vetulani
Polish journal of pharmacology,
PMID:8012475
-
The responsiveness of cerebral cortical adrenergic receptors after chronic administration of atypical antidepressant mianserin.
I Nalepa, J Vetulani
Journal of psychiatry & neuroscience : JPN,
PMID:8204564
-
Retrieval associated cholinergic activity and its inhibition by memory updating.
P Popik, I Nalepa, J Mamczarz, J Vetulani
Life sciences,
PMID:8164507
-
The effects of chlorpromazine and haloperidol on second messenger systems related to adrenergic receptors.
I Nalepa
Polish journal of pharmacology,
PMID:8118483
-
Phorbol ester and central chemosympathectomy augment beta-adrenoceptor response by different mechanisms.
I Nalepa, J Vetulani
Polish journal of pharmacology,
PMID:8401769
-
The effect of calcium channel blockade on the action of chronic ECT and imipramine on responses of alpha 1- and beta-adrenoceptors in the rat cerebral cortex.
I Nalepa, J Vetulani
Polish journal of pharmacology,
PMID:8401774
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Enhancement of the responsiveness of cortical adrenergic receptors by chronic administration of the 5-hydroxytryptamine uptake inhibitor citalopram.
I Nalepa, J Vetulani
Journal of neurochemistry,
PMID:8388032
-
Centpropazine affinity to cortical noradrenergic receptors and effect on their responsiveness in the rat.
M Dikshit, E Chalecka-Franaszek, I Nalepa
The Journal of pharmacy and pharmacology,
PMID:8097784
-
Effects of excitatory amino acids on inositol phosphate accumulation in slices of the cerebral cortex of young and aged rats.
I Nalepa, A Pintor, E Chalecka-Franaszek, S Fortuna, H Michalek, J Vetulani
Neurochemical research,
PMID:8097298
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Effects of diisopropyl fluorophosphate on muscarinic-M1-receptors and on receptor-mediated responsiveness of the phosphatidyl-inositol system in the cerebral cortex of rats.
A Pintor, S Fortuna, I Nalepa, H Michalek
Neurotoxicology,
PMID:1508432
-
Involvement of protein kinase C in the mechanism of in vitro effects of imipramine on generation of second messengers by noradrenaline in cerebral cortical slices of the rat.
I Nalepa, J Vetulani
Neuroscience,
PMID:1661384
-
Strain differences in changes in some parameters of cerebral cortical adrenergic system following chronic imipramine administration to rats.
J Vetulani, I Nalepa, P Popik
Polish journal of pharmacology and pharmacy,
PMID:1660132
-
Second messengers: rate of formation as an index of receptor reactivity.
I Nalepa, J Vetulani
Acta neurobiologiae experimentalis,
PMID:2131745
-
Different mechanisms of beta-adrenoceptor down-regulation by chronic imipramine and electroconvulsive treatment: possible role for protein kinase C.
I Nalepa, J Vetulani
Journal of neurochemistry,
PMID:1650396
-
Avoidance learning during antidepressant withdrawal in mice.
M Sansone, M Battaglia, J Ekblom, I Nalepa, J Vetulani
The Journal of pharmacy and pharmacology,
PMID:1676061
-
Different calcium requirements during incorporation of myo-inositol into membrane lipids for phosphatidylinositol hydrolysis stimulated by carbachol and noradrenaline.
I Nalepa, E Chalecka-Franaszek, J Vetulani
Polish journal of pharmacology and pharmacy,
PMID:2097596
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Differences in beta-adrenergic regulation of cyclic AMP formation in cerebral cortical slices of the rat and spiny mouse--Acomys cahirinus.
E Chalecka-Franaszek, I Nalepa, J Vetulani
Polish journal of pharmacology and pharmacy,
PMID:1980732
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Beta down-regulation induced by repeated vasopressin treatment.
I Nalepa, J Vetulani
European journal of pharmacology,
PMID:2160373
-
[The role of inositol triphosphate and diacylglycerol as intracellular second messengers].
I Nalepa
Postȩpy higieny i medycyny doświadczalnej,
PMID:2697873
-
Increased responsiveness of the cerebral cortical phosphatidylinositol system to noradrenaline and carbachol in senescent rats.
I Nalepa, A Pintor, S Fortuna, J Vetulani, H Michalek
Neuroscience letters,
PMID:2559368
-
Reserpinization enhances electroconvulsive treatment effects on cortical alpha 1-adrenoceptors.
A Pilc, I Nalepa, J Vetulani
European journal of pharmacology,
PMID:2852115
-
A comparison of norepinephrine stimulated inositol phosphate accumulation in cerebral cortex of the Acomys cahirinus, the laboratory mice and the rat.
I Nalepa, A Pilc, E Chalecka-Franciszek, J Vetulani
Polish journal of pharmacology and pharmacy,
PMID:3222183
-
The influence of electroshock on adrenoceptor function in rat brain cerebral cortex: selectivity for the alpha-adrenoceptor site.
A Pilc, E Chalecka-Franaszek, I Nalepa, J Vetulani, S J Enna
European journal of pharmacology,
PMID:2850206
-
[Studies of oxytocinase in obstetrics].
I Nalepa
Ginekologia polska,
PMID:3817572
-
[Further modification by Klimek of the chemical method of Tuppy and Nesvadba for determining cystyl aminopeptidase (oxytocinase) activity in the blood serum].
I Nalepa, K Gadek
Ginekologia polska,
PMID:3803988
-
The evaluation of oxytocinase and total aminopeptidase activities in human seminal plasma.
R Klimek, I Nalepa, A Bacz
Endokrynologia Polska,
PMID:7183443
-
[Activity of selected lysosomal hydrolases in fetal membranes (author's transl)].
I Nalepa, M Schmidt, A Miecznikowski, J Starzewski, A Cachro
Przegla̧d lekarski,
PMID:7455170
-
Pharmacological actions of the antidepressant venlafaxine beyond aminergic receptors.
S. Paul Rossby, D. Hal Manier, Shan Liang, Irena Nalepa, Fridolin Sulser
The international journal of neuropsychopharmacology,
PMID:11281964
Wszystkie publikacje
-
Różnicowanie udziału trzech podtypów receptora alfa(1)-adrenergicznego w efektach leków przeciwdepresyjnych: badania w oparciu o genetyczne modele in vitro oraz in vivo - 2016-02-12 - 2019-02-11
OPUS9 2015/17/B/NZ7/03018
Kierownik
projektu: Prof. dr hab. Irena Nalepa
-
Zanieczyszczenia powietrza a choroby autoimmunologiczne: rola wielofazowej chemii nieorganicznej - 2015-11-02 - 2020-11-01
SYMFONIA3: APARIC 2015/16/W/ST5/00005
Kierownik projektu ze strony
Instytutu Farmakologii PAN Prof. dr hab. Irena Nalepa
-
Badanie interakcji szlaków sygnałowych: receptory alfa1-adrenergiczne – stres komórkowy – apoptoza, w modelu chronicznego łagodnego stresu - zadanie 1.4 - 2010-03-01 - 2014-12-31
POIG.01.01.02-12-004/09 DeMeTer (Depresja –
Mechanizmy – Terapia)
Działanie 1.1 Poddziałanie
1.1.2. Zadanie główne: Modelowanie depresji – strategia poznawania jej etiologii.
Kierownik zadania 1.4. Prof. Irena Nalepa
-
Funkcja in vitro: funkcjonalna aktywność nowych ligandów receptora serotoninowego 5HT(6) i dopaminowego D(2) na poziomie modulacji odpowiedzi wtórnych przekaźników zadanie nr 6 - 2010-01-01 - 2014-12-31
GRANT POIG
ProKog Nr UDA-POIG.01.03.01-12-063/09-02
Działanie 1.3, Poddziałanie 1.3.1: Antagoniści
receptora 5HT(6): nowoczesne leki przeciwpsychotyczne o dodatkowym działaniu
prokognitywnym,Kierownik
zadania nr 6: Prof. dr hab. Irena Nalepa
