Mgr Tomasz Lenda
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Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol.
Adam S Hogendorf, Agata Hogendorf, Rafał Kurczab, Grzegorz Satała, Tomasz Lenda, Maria Walczak, Gniewomir Latacz, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz, Joanna M Wierońska, Monika Woźniak, Paulina Cieślik, Ryszard Bugno, Jakub Staroń, Andrzej J Bojarski
Scientific reports, 10.1038/s41598-017-00822-4
PMID:28473721
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Allosteric Inhibition of Serotonin 5-HT7 Receptors by Zinc Ions.
Grzegorz Satała, Beata Duszyńska, Tomasz Lenda, Gabriel Nowak, Andrzej J Bojarski
Molecular neurobiology, 10.1007/s12035-017-0536-0
PMID:28455702
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The significance of rotational behavior and sensitivity of striatal dopamine receptors in hemiparkinsonian rats: A comparative study of lactacystin and 6-OHDA.
Jolanta Konieczny, Anna Czarnecka, Tomasz Lenda, Kinga Kamińska, Lucyna Antkiewicz-Michaluk
Neuroscience, S0306-4522(16)30611-X 10.1016/j.neuroscience.2016.10.070
PMID:27826109
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Antidepressant-like effects of scopolamine in mice are enhanced by the group II mGlu receptor antagonist LY341495.
Karolina Podkowa, Adrian Podkowa, Kinga Sałat, Tomasz Lenda, Andrzej Pilc, Agnieszka Pałucha-Poniewiera
Neuropharmacology, S0028-3908(16)30367-7 10.1016/j.neuropharm.2016.08.031
PMID:27569995
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Early increase in dopamine release in the ipsilateral striatum after unilateral intranigral administration of lactacystin produces spontaneous contralateral rotations in rats.
J Konieczny, T Lenda, A Czarnecka
Neuroscience, 10.1016/j.neuroscience.2016.02.072 S0306-4522(16)00222-0
PMID:26964686
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Towards new 5-HT7 antagonists among arylsulfonamide derivatives of (aryloxy)ethyl-alkyl amines: Multiobjective based design, synthesis, and antidepressant and anxiolytic properties.
Vittorio Canale, Rafał Kurczab, Anna Partyka, Grzegorz Satała, Tomasz Lenda, Magdalena Jastrzębska-Więsek, Anna Wesołowska, Andrzej J Bojarski, Paweł Zajdel
European journal of medicinal chemistry, 10.1016/j.ejmech.2015.11.040 S0223-5234(15)30376-7
PMID:26698537
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Concentration-Dependent Dual Mode of Zn Action at Serotonin 5-HT1A Receptors: In Vitro and In Vivo Studies.
Grzegorz Satała, Beata Duszyńska, Katarzyna Stachowicz, Anna Rafalo, Bartlomiej Pochwat, Christine Luckhart, Paul R Albert, Mireille Daigle, Kenji F Tanaka, René Hen, Tomasz Lenda, Gabriel Nowak, Andrzej J Bojarski, Bernadeta Szewczyk
Molecular neurobiology,
PMID:26660328
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The preferential nNOS inhibitor 7-nitroindazole and the non-selective one N(G)-nitro-l-arginine methyl ester administered alone or jointly with l-DOPA differentially affect motor behavior and monoamine metabolism in sham-operated and 6-OHDA-lesioned rats.
Anna Czarnecka, Jolanta Konieczny, Tomasz Lenda, Elżbieta Lorenc-Koci
Brain research, 10.1016/j.brainres.2015.08.006 S0006-8993(15)00610-1
PMID:26319690
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Decreased behavioral response to intranigrally administered GABAA agonist muscimol in the lactacystin model of Parkinson's disease may result from partial lesion of nigral non-dopamine neurons: comparison to the classical neurotoxin 6-OHDA.
Jolanta Konieczny, Anna Czarnecka, Kinga Kamińska, Tomasz Lenda, Przemysław Nowak
Behavioural brain research, 10.1016/j.bbr.2015.01.043 S0166-4328(15)00060-1
PMID:25655509
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Salsolinol, an endogenous compound triggers a two-phase opposing action in the central nervous system.
Edyta Możdżeń, Małgorzata Kajta, Agnieszka Wąsik, Tomasz Lenda, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-014-9511-y
PMID:25537852
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Tetracycline-based system for controlled inducible expression of group III metabotropic glutamate receptors.
Barbara Chruścicka, Grzegorz Burnat, Piotr Brański, Paulina Chorobik, Tomasz Lenda, Marcin Marciniak, Andrzej Pilc
Journal of biomolecular screening, 10.1177/1087057114559183
PMID:25394730
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Contribution of the mGluR7 receptor to antiparkinsonian-like effects in rats: a behavioral study with the selective agonist AMN082.
Jolanta Konieczny, Tomasz Lenda
Pharmacological reports : PR,
PMID:24399715
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Lack of neuroprotective effect of celastrol under conditions of proteasome inhibition by lactacystin in in vitro and in vivo studies: implications for Parkinson's disease.
Jolanta Konieczny, Danuta Jantas, Tomasz Lenda, Helena Domin, Anna Czarnecka, Katarzyna Kuter, Maria Śmiałowska, Władysław Lasoń, Elżbieta Lorenc-Koci
Neurotoxicity research, 10.1007/s12640-014-9477-9
PMID:24842651
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Chronic L-DOPA treatment attenuates behavioral and biochemical deficits induced by unilateral lactacystin administration into the rat substantia nigra.
Jolanta Konieczny, Anna Czarnecka, Tomasz Lenda, Kinga Kamińska, Elżbieta Lorenc-Koci
Behavioural brain research, 10.1016/j.bbr.2013.12.019 S0166-4328(13)00762-6
PMID:24361083
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Concentration-dependent opposite effects of 1-benzyl-1,2,3,4-tetrahydroisoquinoline on markers of apoptosis: in vitro and ex vivo studies.
Agnieszka Wąsik, Małgorzata Kajta, Tomasz Lenda, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-013-9436-x
PMID:24190811
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Alterations in the expression of nNOS in the substantia nigra and subthalamic nucleus of 6-OHDA-lesioned rats: the effects of chronic treatment with l-DOPA and the nitric oxide donor, molsidomine.
Anna Czarnecka, Tomasz Lenda, Helena Domin, Jolanta Konieczny, Maria Smiałowska, Elżbieta Lorenc-Koci
Brain research, 10.1016/j.brainres.2013.10.011 S0006-8993(13)01376-0
PMID:24129225
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Molsidomine, a nitric oxide donor, modulates rotational behavior and monoamine metabolism in 6-OHDA lesioned rats treated chronically with L-DOPA.
Elżbieta Lorenc-Koci, Anna Czarnecka, Tomasz Lenda, Kinga Kamińska, Jolanta Konieczny
Neurochemistry international, 10.1016/j.neuint.2013.09.021 S0197-0186(13)00249-0
PMID:24090640
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Antidepressant and antipsychotic activity of new quinoline- and isoquinoline-sulfonamide analogs of aripiprazole targeting serotonin 5-HT₁A/5-HT₂A/5-HT₇ and dopamine D₂/D₃ receptors.
Paweł Zajdel, Krzysztof Marciniec, Andrzej Maślankiewicz, Katarzyna Grychowska, Grzegorz Satała, Beata Duszyńska, Tomasz Lenda, Agata Siwek, Gabriel Nowak, Anna Partyka, Dagmara Wróbel, Magdalena Jastrzębska-Więsek, Andrzej J Bojarski, Anna Wesołowska, Maciej Pawłowski
European journal of medicinal chemistry, 10.1016/j.ejmech.2012.11.042 S0223-5234(12)00719-2
PMID:23279866
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The extent of neurodegeneration and neuroprotection in two chemical in vitro models related to Parkinson's disease is critically dependent on cell culture conditions.
D Jantas, A Roman, J Kuśmierczyk, E Lorenc-Koci, J Konieczny, T Lenda, W Lasoń
Neurotoxicity research, 10.1007/s12640-012-9374-z
PMID:23307753
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Different effects of intranigral and intrastriatal administration of the proteasome inhibitor lactacystin on typical neurochemical and histological markers of Parkinson's disease in rats.
Elżbieta Lorenc-Koci, Tomasz Lenda, Lucyna Antkiewicz-Michaluk, Jadwiga Wardas, Helena Domin, Maria Smiałowska, Jolanta Konieczny
Neurochemistry international, 10.1016/j.neuint.2011.03.013
PMID:21419185
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The antidepressant-like action of metabotropic glutamate 7 receptor agonist N,N'-bis(diphenylmethyl)-1,2-ethanediamine (AMN082) is serotonin-dependent.
Agnieszka Pałucha-Poniewiera, Piotr Brański, Tomasz Lenda, Andrzej Pilc
The Journal of pharmacology and experimental therapeutics, 10.1124/jpet.110.169730
PMID:20562216
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Increased synphilin-1 expression in human elderly brains with substantia nigra Marinesco bodies.
Anna Krygowska-Wajs, Tomasz Lenda, Dariusz Adamek, Marek Moskała, Katarzyna Kuter, Jerzy Kunz, Maria Smiałowska, Krystyna Ossowska
Pharmacological reports : PR,
PMID:19211984
-
The influence of acute and chronic administration of 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline on the function of the nigrostriatal dopaminergic system in rats.
E Lorenc-Koci, L Antkiewicz-Michaluk, A Kamińska, T Lenda, B Zieba, J Wierońska, M Smiałowska, G Schulze, H Rommelspacher
Neuroscience, 10.1016/j.neuroscience.2008.08.050
PMID:18809471
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The influence of modifications in imide fragment structure on 5-HT(1A) and 5-HT(7) receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines.
Maria H Paluchowska, Ryszard Bugno, Beata Duszyńska, Ewa Tatarczyńska, Agnieszka Nikiforuk, Tomasz Lenda, Ewa Chojnacka-Wójcik
Bioorganic & medicinal chemistry,
PMID:17825569
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A slowly developing dysfunction of dopaminergic nigrostriatal neurons induced by long-term paraquat administration in rats: an animal model of preclinical stages of Parkinson's disease?
K Ossowska, J Wardas, M Smiałowska, K Kuter, T Lenda, J M Wierońska, B Zieba, P Nowak, J Dabrowska, A Bortel, A Kwieciński, S Wolfarth
The European journal of neuroscience,
PMID:16190885
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