Pracownicy - Instytut Farmakologii im. Jerzego Maja

Back and to the Future: From Neurotoxin-Induced to Human Parkinson's Disease Models. Mikko Airavaara, Ilmari Parkkinen, Julia Konovalova, Katrina Albert, Piotr Chmielarz, Andrii Domanskyi
Current protocols in neuroscience, 10.1002/cpns.88
PMID:32049438

MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System. Emmi Pakarinen, Tatiana Danilova, Vootele Võikar, Piotr Chmielarz, Petteri Piepponen, Mikko Airavaara, Mart Saarma, Maria Lindahl
eNeuro, ENEURO.0477-19.2019 10.1523/ENEURO.0477-19.2019
PMID:32005751

Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases. Julia Konovalova, Dmytro Gerasymchuk, Ilmari Parkkinen, Piotr Chmielarz, Andrii Domanskyi
International journal of molecular sciences, E6055 10.3390/ijms20236055
PMID:31801298

Functionally Distinctive Ptch Receptors Establish Multimodal Hedgehog Signaling in the Tooth Epithelial Stem Cell Niche. Martin Binder, Piotr Chmielarz, Peter J Mckinnon, Leah C Biggs, Irma Thesleff, Anamaria Balic
Stem cells (Dayton, Ohio), 10.1002/stem.3042
PMID:31145830

Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism. Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Justyna Barut, Piotr Chmielarz, Marta Kot, Monika Bagińska, Rosanna Parlato, Władysława Anna Daniel, Irena Nalepa
Scientific reports, 10.1038/s41598-019-41756-3
PMID:30918302

Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects. Paweł Zajdel, Tomasz Kos, Krzysztof Marciniec, Grzegorz Satała, Vittorio Canale, Krzysztof Kamiński, Małgorzata Hołuj, Tomasz Lenda, Robert Koralewski, Marek Bednarski, Leszek Nowiński, Jacek Wójcikowski, Władysława A Daniel, Agnieszka Nikiforuk, Irena Nalepa, Piotr Chmielarz, Justyna Kuśmierczyk, Andrzej J Bojarski, Piotr Popik
European journal of medicinal chemistry, S0223-5234(18)30002-3 10.1016/j.ejmech.2018.01.002
PMID:29407591

Dicer and microRNAs protect adult dopamine neurons. Piotr Chmielarz, Julia Konovalova, Syeda Sadia Najam, Heike Alter, Timo Petteri Piepponen, Holger Erfle, Kai C Sonntag, Günther Schütz, Ilya A Vinnikov, Andrii Domanskyi
Cell death & disease, 10.1038/cddis.2017.214
PMID:28542144

Lack of riluzole efficacy in the progression of the neurodegenerative phenotype in a new conditional mouse model of striatal degeneration. Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Piotr Chmielarz, Monika Bagińska, Irena Nalepa
PeerJ, 10.7717/peerj.3240
PMID:28462043

Depressive-like immobility behavior and genotype × stress interactions in male mice of selected strains. Piotr Chmielarz, Grzegorz Kreiner, Justyna Kuśmierczyk, Marta Kowalska, Adam Roman, Katarzyna Tota, Irena Nalepa
Stress (Amsterdam, Netherlands), 10.3109/10253890.2016.1150995
PMID:26941077

Selective ablation of glucocorticoid receptors in the noradrenergic system affects evening corticosterone levels in a sex-dependent manner. Piotr Chmielarz, Grzegorz Kreiner, Irena Nalepa
Pharmacological reports : PR, 10.1016/j.pharep.2015.05.013 S1734-1140(15)00100-0
PMID:26481542

Disruption of glucocorticoid receptors in the noradrenergic system leads to BDNF up-regulation and altered serotonergic transmission associated with a depressive-like phenotype in female GR(DBHCre) mice. Piotr Chmielarz, Grzegorz Kreiner, Marta Kot, Agnieszka Zelek-Molik, Marta Kowalska, Monika Bagińska, Władysława Anna Daniel, Irena Nalepa
Pharmacology, biochemistry, and behavior, 10.1016/j.pbb.2015.08.001 S0091-3057(15)30038-1
PMID:26261018

Gender differences in genetic mouse models evaluated for depressive-like and antidepressant behavior. Grzegorz Kreiner, Piotr Chmielarz, Adam Roman, Irena Nalepa
Pharmacological reports : PR,
PMID:24553006

Gender-dependent activity of CYP3A is indirectly modified by GR in the noradrenergic system. Marta Kot, Grzegorz Kreiner, Piotr Chmielarz, Justyna Kuśmierczyk, Irena Nalepa, Władysława A Daniel
Pharmacological reports : PR,
PMID:24399741

Inactivation of glucocorticoid receptor in noradrenergic system influences anxiety- and depressive-like behavior in mice. Piotr Chmielarz, Justyna Kuśmierczyk, Rosanna Parlato, Günther Schütz, Irena Nalepa, Grzegorz Kreiner
PloS one, 10.1371/journal.pone.0072632
PMID:23977333

Acute and repeated treatment with the 5-HT7 receptor antagonist SB 269970 induces functional desensitization of 5-HT7 receptors in rat hippocampus. Krzysztof Tokarski, Agnieszka Zelek-Molik, Beata Duszyńska, Grzegorz Satała, Bartosz Bobula, Magdalena Kusek, Piotr Chmielarz, Irena Nalepa, Grzegorz Hess
Pharmacological reports : PR,
PMID:22661174

Dr Piotr Chmielarz

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