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OBITUARY - Dr. Helena Tomczyk (1911-1998). Editorial Board (p. 1) REVIEW - Melatonin: from biochemistry to therapeutic applications. Jolanta B. Zawilska, Jerzy Z. Nowak (p. 3) MINIREVIEW - Role of MAO A and B in neurotransmitter metabolism and behavior. Jean C. Shih, K. Chen, M. J. Ridd (p. 25) MINIREVIEW - Enzyme-catalyzed bioactivation of cyclic tertiary amines to form potential neurotoxins. Neal Castagnoli Jr., Kay P. Castagnoli, Cornelis J. Van der Schyf, Etsuko Usuki, Kazuo Igarashi, Stefanus J. Steyn, Richard R. Riker (p. 31) MINIREVIEW - Interactive modulation by dopamine and serotonin neurons of receptor sensitivity of the alternate neurochemical system. Richard M. Kostrzewa, Ryszard Brus, Ken W. Perry (p. 39) MINIREVIEW - Influence of long-lasting administration of neuroleptics on cortical NMDA receptors and phencyclidine-induced deficit in the sensorimotor gating in rats. Krystyna Ossowska, Małgorzata Pietraszek, Jadwiga Wardas, Gabriel Nowak, Stanisław Wolfarth (p. 49) MINIREVIEW - Role of dopamine systems in obsessive-compulsive disorder (OCD): implications from a novel psychostimulant-induced animal model. Henry Szechtman, Kirsten Culver, David Eilam (p. 55) Effect of antidepressant drugs on veratridine-evoked glutamate and aspartate release in rat prefrontal cortex. Krystyna Gołembiowska, Alicja Żylewska (p. 63) Influence of fluoroquinolones on the central action of ethanol. Jarosław S. Strzelec, Elżbieta Kubik-Bogucka, Elżbieta Czarnecka (p. 71) Further proctolin analogues modified in the position 2 of the peptide chain and their myotropic effects in insects Tenebrio molitor and Schistocerca gregaria. Mariola Kuczer, Grzegorz Rosiński, Jonathan Issberner, Richard Osborne, Danuta Konopińska (p. 79) SHORT COMMUNICATION Stimulatory effect of pituitary adenylate cyclase-activating polypeptide (PACAP) on cyclic AMP formation in the hypothalamus and cerebral cortex of four avians and rat. Jerzy Z. Nowak, Katarzyna Kuba, Jolanta B. Zawilska (p. 87) Papers of Third Conference on PROGRESS IN ETIOPATHOGENESIS OF SEIZURES (p. 95)

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MINIREVIEW - Transcellular biosynthesis of eicosanoids. Ryszard J. Gryglewski (p. 113) Alcohol intake and brain [3H]muscimol binding sites in alcohol-preferring and non-preferring rats. Wanda Dyr, Marek Siemiątkowski, Adam Płaźnik, Andrzej Bidziński, Wojciech Kostowski (p. 119) Effects of calcium channel ligands on anaesthetic properties of ethanol in mice. Grażyna Biała (p. 125) Cardiovascular effects of secretin in intact rats versus rats with streptozotocin-induced diabetes mellitus. Ewa Sitniewska, Róża J. Wiśniewska (p. 131) Role of reperfusion with polyelectrolyte solution and BN 52021 in hemorrhagic shock-induced changes in rat lungs. Marzanna Makarewicz-Płońska, Elżbieta Skrzydlewska, Ryszard Farbiszewski (p. 137) Ca2+-RELATED MECHANISMS IN INTRACELLULAR SIGNALLING IVth Conference of the Polish Neuroscience Society and the Department of Biogenic Amines of the Polish Academy of Sciences Calcium-dependent signaltransduction pathways in plants - phytochrome mechanism of action as an example. Andrzej Tretyn (p. 145) Capacitative calcium entry. Glioma C6 as a model of nonexcitable cells. Jolanta Barańska, Krzysztof Przybyłek, Paweł Sabała (p. 153) Role of calcium-independent phospholipase A2 in the regulation of calcium influx into Jurkat cells. Krzysztof Zabłocki, Jerzy Duszyński (p. 163) Role of calcium ions in vertebrate phototransduction. Wojciech A. Gorczyca (p. 167) Calretinin - sensor or buffer - function still unclear. Katarzyna Billing-Marczak, Jacek Kuźnicki (p. 173) Voltage-operated calcium channels: characteristics and their role in the mechanism of action of psychotropic drugs. Lucyna Antkiewicz-Michaluk (p. 179) Main systems involved in calcium regulation in cardiac muscle cells and their functional relationship. Antoni Wrzosek (p. 187) Application of calcium channel blockers in the treatment of cardiovascular diseases. Zbigniew S. Herman (p. 201)

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REVIEW - Liposome-based drug delivery systems. Marek Langner, Teresa E. Kral (p. 211) Clinically available NMDA antagonist, memantine, attenuates tolerance to analgesic effects of morphine in a mouse tail flick test. Piotr Popik, Ewa Kozela (p. 223) Gene transfer of vascular endothelial growth factor and endothelial nitric oxide synthase - implications for gene therapy in cardiovascular diseases. Józef Dulak, Alicja Józkowicz, Ibeth Guevara, Aldona Dembińska-Kieć (p. 233) Effects of doxycycline on the development of bone damage caused by prednisolone in rats. Joanna Folwarczna, Waldemar Janiec, Katarzyna Firlus, Ilona Kaczmarczyk-Sedlak (p. 243) SHORT COMMUNICATION Analgesic activity of thioureido derivatives of arylsemicarbazones. Vibha Mishra, Surendra N. Pandeya, Paras N. Singh, Dinesh C. Rupainwar (p. 253) PRELIMINARY COMMUNICATION Immunological activity of new heterocyclic amides of 5-amino-3-methylisoxazole-4-carboxylic acid. Stanisław Ryng, Michał Zimecki, Adam Fedorowicz, Aleksander Koll (p. 257) Abstracts of the EIGHTH DAYS of NEUROPSYCHOPHARMACOLOGY "DECADE of the BRAIN" (p. 269)

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Influence of olanzapine on cognitive functions and catalepsy in rats after single and chronic administration. Elżbieta Nowakowska, Alfons Chodera, Krzysztof Kus (p. 295) Modification of avoidance responding by amphetamine and dopamine receptor antagonists. Ewa Jakubowska-Dogru (p. 301) Effect of desipramine during infancy and preweanling on dorsal striatal dopamine D1 and D2 receptor binding in adolescence in the rat. Ilkka Hilakivi, Juha Rinne, Päivi Marjamäki (p. 311) Pharmacological profile of milnacipran, a new antidepressant, given acutely. Zofia Rogóż, Grażyna Skuza, Jerzy Maj (p. 317) Effects of the NMDA/glycine receptor antagonist, L-701,324, on morphine- and cocaine-induced place preference. Jolanta Kotlińska, Grażyna Biała (p. 323) Submandibular gland peptide-T (SGP-T) modulates ventricular function in response to intravenous endotoxin. Ronald Mathison, Marta Kubera, Joseph S. Davison (p. 331) Effect of oxidative stress and erythropoietin on cytoskeletal protein and lipid organization in human erythrocytes. Tapasi Das Choudhury, Nandita Das, Aindrila Chattopadhyay, Asoke G. Datta (p. 341) 9-Substituted 1,2,3,4-tetrahydro-beta-carbolin-1-ones, new 5-HT1A and 5-HT2A receptor ligands. Maria J. Mokrosz, Jan Boksa, Sijka Charakchieva-Minol, Anna Wesołowska, Jolanta Borycz (p. 351) SHORT COMMUNICATIONS Valproate- and aminophylline-induced ‘wet dog shakes’ - a function of dose and time. Prathibha E. A. Jose, Poonam Kullu, Joy David, Chanda Kulkarni (p. 357) Comparison of effectiveness of two schedules of rapid transcranial magnetic stimulation on enhancement of responsiveness to apomorphine. Tomasz Zyss, Jacek Mamczarz, Adam Roman, Jerzy Vetulani (p. 363) Participation of opioid mechanism in the antinociceptive effects induced by oxaprotiline enantiomers in mice. Anna Wesołowska, Jolanta Borycz (p. 367)

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Adrenergic receptors’ responsiveness after acute and chronic treatment with haloperidol in the presence of calcium channel blockade. Irena Nalepa, Grzegorz Kreiner, Marta Kowalska, Marek Sanak, Jerzy Vetulani (p. 377) Lack of effect of a glycineB receptor partial agonist on amphetamine-induced sensitization in mice. Edmund Przegaliński, Joanna Siwanowicz, Ewa Chojnacka-Wójcik (p. 385) Reversal of stress-induced deficit in aggression by monoamine oxidase inhibitors. Grażyna Ossowska, Bożena Klenk-Majewska, Zofia Danilczuk, Andrzej Wróbel, Iwona Żebrowska-Łupina (p. 391) Pharmacological profile of reboxetine, a representative of new class of antidepressant drugs, selective noradrenaline reuptake inhibitor (NARI), given acutely. Zofia Rogóż, Andrzej Wróbel, Monika Krasicka-Domka, Jerzy Maj (p. 399) Some pharmacological properties of new analogs of MP 3022, the 5-HT1A receptor antagonist. Ewa Chojnacka-Wójcik, Aleksandra Kłodzińska, Ewa Tatarczyńska, Maria H. Paluchowska (p. 405) Effect of the amide fragment on 5-HT1A receptor activity of some analogs of MP 3022. Maria H. Paluchowska, Sijka Charakchieva-Minol, Ewa Tatarczyńska, Aleksandra Kłodzińska (p. 415) Imipramine-induced increase in the inhibitory effect of adenosine receptor activation in the hippocampus. Agnieszka Zahorodna, Maria Bijak (p. 423) Protective effect of alpha-keto acids on the oxidative hemolysis. Maria Sokołowska, Agnieszka Oleszek, Lidia Włodek (p. 429) Effects of selective cytochrome P-450 inhibitors on the metabolism of thioridazine. In vitro studies. Władysława A. Daniel, Maciej Syrek, Anna Haduch (p. 435) SHORT COMMUNICATIONS L-N6-(1-iminoethyl)-lysine (L-NIL) but not S-methylisothiourea sulphate (SMT) displays selectivity towards NOS-2. Stefan Chłopicki, Rafał Olszanecki, Andrzej Jakubowski, Magdalena Łomnicka, Ryszard J. Gryglewski (p. 443)

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The centenary of Professor Supniewski’s birth. Editorial Board (p. 453) REVIEW - Angiogenesis inhibitors. New anticancer strategy. Witold Zgodziński, Grzegorz Wallner, Andrzej Dąbrowski (p. 455) Behavioral and memory improving effects of mirtazapine in rats. Elżbieta Nowakowska, Alfons Chodera, Krzysztof Kus (p. 463) Synergistic effect of pramipexole and sertraline in the forced swimming test. Jerzy Maj, Zofia Rogóż (p. 471) Effect of sigma ligands on the cocaine-induced convulsions in mice. Grażyna Skuza (p. 477) Influence of piracetam and oxiracetam on the content of high-energy phosphates and morphometry of astrocytes in vitro. Bożena Gabryel, Henryk I. Trzeciak, Anna Pudełko, Paweł Cieślik (p. 485) Moclobemide enhances aversively motivated learning and memory in rats. Marek Frank, Jan J. Braszko (p. 497) Effects of intravenous anesthetic agents on pregnant myometrium. Bilge Karsli, Tijen Kaya, Ali Çetin (p. 505) Influence of alpha-escin on the femoral bone strength in ovariectomized rats. Maria Pytlik, Waldemar Janiec, Urszula Cegieła, Leszek Śliwiński (p. 511) QSAR studies on antimalarial activities of 2-phenyl-4-quinoline-carbinolamines. Vijay K. Agrawal, Sangeeta Sinha, Shahnaz Bano, Padmakar V. Khadikar (p. 517) SHORT COMMUNICATIONS Haloperidol treatment selectively affects expression of Gai3 subunit mRNA in specific regions of the rat brain. Marek Sanak, Grzegorz Kreiner, Marta Kowalska, Irena Nalepa, Jerzy Vetulani (p. 525) Allopregnanolone attenuates kainate-induced toxicity in primary cortical neurons and PC12 neuronal cells. Małgorzata Kajta, Bogusława Budziszewska, Władysław Lasoń (p. 531) PRELIMINARY COMMUNICATIONS Is serum copper a „trait marker” of unipolar depression? A preliminary clinical study. Małgorzata Schlegel-Zawadzka, Andrzej Zięba, Dominika Dudek, Joanna Żak-Knapik, Gabriel Nowak (p. 535) Effect of chronic antidepressant or electroconvulsive shock treatment on mGLUR1a immunoreactivity expression in the rat hippocampus. Marta Bajkowska, Piotr Brański, Maria Śmiałowska, Andrzej Pilc (p. 539) Selective group II glutamate metabotropic receptor agonist LY354740 attenuates pentetrazole- and picrotoxin-induced seizures. Aleksandra Kłodzińska, Ewa Chojnacka-Wójcik, Andrzej Pilc (p. 543) Leukocyte subsets in treatment-resistant major depression. Marta Kubera, Dirk Van Bockstaele, Michael Maes (p. 547)