Copyright © 1999 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 1999, 51, 25-29
ISSN 1230-6002
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MINIREVIEW
 ROLE OF MAO A AND B IN NEUROTRANSMITTER METABOLISM AND BEHAVIOR1
 Jean C. Shih#, K. Chen, M.J. Ridd
 Department of Molecular Pharmacology and Toxicology, University of Southern California, School of Pharmacy,
Department of Cell and Neurobiology, School of Medicine, 1985 Zonal Avenue, Los Angeles, California 90033, USA

Role of MAO A and B in neurotransmitter metabolism and behavior. J.C. SHIH, K. CHEN, M.J. RIDD. Pol. J. Pharmacol., 1999, 51, 25-29.

MAO (monoamine oxidase) A and B are key isoenzymes that degrade biogenic and dietary amines. MAO A preferentially oxidizes serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), whereas MAO B preferentially oxidizes phenylethylamine (PEA). Both forms can oxidize dopamine (DA). However, the substrate specificity overlap and the in vivo function of these two isoenzymes is not clear. Recently, we have shown that MAO A and B knock-out (KO) mice exhibit distinct differences in neurotransmitter metabolism and behavior. MAO A KO mice have elevated brain levels of 5-HT, NE and DA and manifest aggressive behavior similar to men with a deletion of MAO A. In contrast, MAO B KO mice do not exhibit aggression and only levels of PEA are increased. Both MAO A and B KO mice show increased reactivity to stress. Taken together, these results suggest that MAO A and B have distinctly different roles in monoamine metabolism. Further, these mice are valuable models for investigating the role of monoamines in psychoses and neurodegenerative and stress-related disorders.

Key words: aggression, knock-out mice, monoamine oxidase
  1Lecture presented during XIII Congress of the Polish Pharmacological Society, September 1998.
  # correspondence
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