Copyright © 1999 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 1999, 51, 163-166
ISSN 1230-6002
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ROLE OF CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IN THE REGULATION OF CALCIUM INFLUX INTO JURKAT CELLS
 Krzysztof Zabłocki#, Jerzy Duszyński
 Department of Cellular Biochemistry, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Pasteura 3, PL 02-093 Warszawa, Poland

Role of calcium-independent phospholipase A2 in the regulation of calcium influx into Jurkat cells. K. ZABŁOCKI, J. DUSZYŃSKI. Pol. J. Pharmacol., 1999, 51, 163-166.

The role of phospholipases A2 in calcium metabolism is briefly reviewed. Some data are presented indicating that calcium-independent phospholipase A2 may modify the activity of store-activated calcium channels in the plasma membrane of Jurkat cells. Helss, a specific inhibitor of calcium-independent phospholipase A2 blocks the store-operated signal that is transmitted from ER to the plasma membrane.

Key words: store-activated calcium channels, phospholipases A2, calcium metabolism
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