|
Copyright © 1999 by Institute of Pharmacology Polish Academy of Sciences |
Pol. J. Pharmacol., 1999, 51, 153-162 ISSN 1230-6002 |
|
Capacitative calcium entry. Glioma C6 as a model of nonexcitable cells.
J. BARAŃSKA, K. PRZYBYŁEK, P. SABAŁA. Pol. J. Pharmacol., 1999, 51, 153-162. Although the mechanism of the capacitative Ca2+ entry is still a mysterious process, it has been presently accepted that it occurs through plasma membrane channel pores rather than through a carrier mechanism. As it has been proposed by Putney (Cell Calcium, 1986, 7, 1-12), Ca2+ entry is directly dependent on the state of filling of the endoplasmic reticulum Ca2+ stores, i.e. it is activated by the depletion of the endoplasmic reticulum Ca2+ pool. However, the nature of the signal for activation of Ca2+ entry is still unknown. The biphasic capacitative Ca2+ entry involves inositol phosphate system and is ubiquitous in all nonexcitable cells. We have shown that glioma C6 cells belong to such type of cells and are characterized by a typical capacitative Ca2+ entry pathway. The characteristics of this Ca2+ influx is summarized and the hypotheses about its mechanism of activation are discussed. Key words: calcium, capacitative entry, nonexcitable cells, glioma C6 |
| Back to: Top | PJP - Home Page | |