Copyright © 1999 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 1999, 51, 531-534
ISSN 1230-6002
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SHORT COMMUNICATION
 ALLOPREGNANOLONE ATTENUATES KAINATE-INDUCED TOXICITY IN PRIMARY CORTICAL NEURONS AND PC12 NEURONAL CELLS
 Małgorzata Kajta#, Bogusława Budziszewska, Władysław Lasoń
 Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland

Allopregnanolone attenuates kainate-induced toxicity in primary cortical neurons and PC12 neuronal cells. M. KAJTA, B. BUDZISZEWSKA, W. LASOŃ. Pol. J. Pharmacol., 1999, 51, 531-534.

In this study, we demonstrated that allopregnanolone at 500 and 1000 nM significantly inhibited kainate-induced lactate dehydrogenase release from primary cortical cells by ca. 25 and 50%, respectively. Furthermore, allopregnanolone doses of 100 and 500 nM decreased cytotoxic effects of kainate (150 µM, 24-hour exposure) in PC12 neuronal cells by about 55 and 37%, respectively. These data strongly support neuroprotective effects of allopregnanolone observed in vivo.

Key words: neurosteroids, kainate neurotoxicity, primary neuronal culture, PC12 cells
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