Copyright © 1999 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 1999, 51, 385-390
ISSN 1230-6002
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LACK OF EFFECT OF A GLYCINEB RECEPTOR PARTIAL AGONIST ON AMPHETAMINE-INDUCED SENSITIZATION IN MICE
 Edmund Przegaliński#, Joanna Siwanowicz, Ewa Chojnacka-Wójcik
 Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland

Lack of effect of a glycineB receptor partial agonist on the amphetamine-induced sensitization in mice. E. PRZEGALIŃSKI, J. SIWANOWICZ, E. CHOJNACKA-WÓJCIK. Pol. J. Pharmacol., 1999, 51, 385-390.

Effects of 1-aminocyclopropanecarboxylic acid (ACPC), a partial agonist of glycineB receptors, on the expression and development of sensitization to the locomotor activity of amphetamine (AMPH, 2.5 mg/kg) were studied in mice. ACPC in doses of 100-400 mg/kg did not affect the expression of AMPH sensitization. Combined injections of ACPC (200-400 mg/kg) and AMPH during the development of sensitization did not change the expression of sensitization to the challenge dose of AMPH 3 days after the drug withdrawal. Acute administration of ACPC, 400 mg/kg, enhanced the locomotor hyperactivity induced by a single dose of AMPH, that effect being probably connected with its own stimulatory action of that dose of ACPC.
Summing up, our results show that ACPC affects neither the development nor the expression of AMPH sensitization in mice.

Key words: amphetamine, 1-aminocyclopropanecarboxylic acid, glycineB receptors, sensitization, mice
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