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Copyright © 1999 by Institute of Pharmacology Polish Academy of Sciences |
Pol. J. Pharmacol., 1999, 51, 539-541 ISSN 1230-6002 |
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Effect of chronic antidepressant or electroconvulsive shock treatment on mGLUR1a immunoreactivity expression in the rat hippocampus.
M. BAJKOWSKA, P. BRAŃSKI, M. ŚMIAŁOWSKA, A. PILC. Pol. J. Pharmacol., 1999, 51, 539-541. The effect of chronic imipramine (IMI) or electroconvulsive shock (ECS) treatment on the expression of group Ia metabotropic glutamate receptors (mGluR1a) was studied in the rat hippocampus by an immunohistochemical method, using a specific monoclonal antibody. It was found that both those treatments increased the number of mGluR1a immunoreactive neurons in a pyramidal layer of the CA3 hippocampal field. Moreover, IMI, but not ECS, increased the density of mGluR1a positive neurons in the hilus. The obtained results indicate a possible influence of the antidepressive treatment on the mGluR1a expression in some hippocampal fields. Key words: thioridazine metabolism, rat, cytochrome P-450 inhibition, quinine, metyrapone, alpha-naphthoflavone, sulfaphenazole, erythromycin |
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