Copyright © 1999 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 1999, 51, 543-545
ISSN 1230-6002
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PRELIMINARY COMMUNICATION
 SELECTIVE GROUP II GLUTAMATE METABOTROPIC RECEPTOR AGONIST LY354740 ATTENUATES PENTETRAZOLE- AND PICROTOXIN-INDUCED SEIZURES
 Aleksandra Kłodzińska1, Ewa Chojnacka-Wójcik1, Andrzej Pilc 1,2,#
 1 Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland,
2 Institute of Public Health, Collegium Medicum, Jagiellonian University, Kraków, Poland

Selective group II glutamate metabotropic receptor agonist LY354740 attenuates pentetrazole- and picrotoxin-induced seizures. A. KŁODZIŃSKA, E. CHOJNACKA-WÓJCIK, A. PILC. Pol. J. Pharmacol., 1999, 51, 543-545.

There are several data indicating the involvement of metabotropic glutamate receptors (mGluR) in seizures and epileptogenesis. In the present experiments, the selective group II mGluR agonist (+)-2-aminobicyclo-[3.1.0]hexane-2,6-dicarboxylic acid (LY 354740) at doses from 4 to 16 mg/kg) administered prior to the injection of pentetrazole (80 mg/kg) or picrotoxin (3.2 mg/kg) produced a dose-dependent decrease in the number of mice exhibiting clonic convulsions. Our data suggest that group II mGluR agonist LY 354740 possesses antiseizure activity.

Key words: metabotropic glutamate receptors, LY354740, mGluR2/3 agonist, seizures, pentetrazole, picrotoxin, mice
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