Copyright © 1999 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 1999, 51, 547-549
ISSN 1230-6002
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PRELIMINARY COMMUNICATION
 LEUKOCYTE SUBSETS IN TREATMENT-RESISTANT MAJOR DEPRESSION
 Marta Kubera#, Dirk Van Bockstaele1, Michael Maes2,3,4
 Department of Endocrinology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland,
1 Department of Hematology, University Hospital of Antwerp, B-2650 Edegem, Wilrijkstraat 10, Antwerp, Belgium, 2 Department of Psychiatry, University of Maastricht, The Netherlands, 3 Department of Psychiatry, Vanderbilt University, Nashville, USA, 4 Clinical Research Center for Mental Health, Antwerp, Belgium

Leukocyte subsets in treatment-resistant major depression. M. KUBERA, D. VAN BOCKSTAELE, M. MAES. Pol. J. Pharmacol., 1999, 51, 547-549.

Patients with treatment-resistant major depression had a significantly higher percentage of helper CD4+ T cells and immature double positive CD4+CD8+ T cells in their blood, and higher CD4+/CD8+ ratio than healthy controls. These results suggest activation of T helper immuno-response and disturbance in thymus function in these patients.

Key words: leukocyte subsets, treatment-resistant major depression, CD4+ helper T cells
  # correspondence
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