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Copyright © 1999 by Institute of Pharmacology Polish Academy of Sciences |
Pol. J. Pharmacol., 1999, 51, 137-142 ISSN 1230-6002 |
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Role of reperfusion with polyelectrolyte solution and BN 52021 in hemorrhagic shock-induced changes in rat lungs.
M. MAKAREWICZ-PŁOŃSKA, E. SKRZYDLEWSKA, R. FARBISZEWSKI. Pol. J. Pharmacol., 1999, 51, 137-142. The aim of this study was to test whether reperfusion with isotonic standard polyelectrolyte solution alone has any influence on the redox balance in the lung during hemorrhagic shock, and whether reperfusion and BN 52021, used together have better protective effect on free radical lung injury. The results showed that reperfusion with electrolyte solution increased solely glutathione reductase activity (GSSG-R), and diminished the activities of Cu,Zn-superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) as well as the content of SH-groups. Thiobarbituric acid reactive substances (TBA-rs) were much more increased in comparison to hemorrhagic shock. After reperfusion with polyelectrolyte solution and the administration of BN 52021, the antioxidant parameters returned to normal values, while TBA-rs slightly decreased. Key words: ischemia/reperfusion, hemorrhagic shock, lung, antioxidant system, BN 52021 |
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