Copyright © 1999 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 1999, 51, 517-523
ISSN 1230-6002
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QSAR STUDIES ON ANTIMALARIAL ACTIVITIES OF 2-PHENYL-4-QUINOLINE-CARBINOLAMINES
 Vijay K. Agrawala, Sangeeta Sinhaa, Shahnaz Banoa, Padmakar V. Khadikar#,b
 a Department of Chemistry, APS University, Rewa 486 003, India;
b Research Division, Laxmi Pest & Fumigation Pvt. Ltd., 3 Khatipura, Indore 452 007, India

QSAR studies on antimalarial activities of 2-phenyl-4-quinoline-carbinolamines. V.K. AGRAWAL, S. SINHA, S. BANO, P.V. KHADIKAR. Pol. J. Pharmacol., 1999, 51, 517-523.

QSAR study on a series of 2-phenyl-4-quinoline carbinolamine antimalarials was performed using electronic parameters to correlate the electronic features with antimalarial activities. The electronic parameters used were energy of the highest occupied molecular orbitals (EH), energy of the lowest unoccupied molecular orbitals (EL), the total pi-electron energy (ET) and charge density (CD). The results have shown that the antimalarial potential can be modeled by these parameters. The study will aid in efficient designing of this class of antimalarial agents.

Key words: antimalarial agents, carbinolamine derivatives, QSAR studies
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