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Copyright © 1999 by Institute of Pharmacology Polish Academy of Sciences |
Pol. J. Pharmacol., 1999, 51, 511-515 ISSN 1230-6002 |
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Influence of alpha-escin on the femoral bone strength in ovariectomized rats.
M. PYTLIK, W. JANIEC, U. CEGIELA, L. SLIWINSKI. Pol. J. Pharmacol., 1999, 51, 511-515. The aim of the present study was to investigate the effect of alpha-escin (35 mg/kg po, daily) administered for 4 weeks on the femoral bone strength in 3-month-old ovariectomized Wistar rats. The experiments were carried out on four groups of animals: I (C) - control sham operated rats, II (OVX) - ovariectomized rats, III (E) - sham operated rats which were administered alpha-escin, IV (OVX+E) - ovariectomized rats which were administered alpha-escin. Bilateral ovariectomy caused osteopenic skeletal changes in mature female rats. alpha-Escin (35 mg/kg po, daily) administered to the ovariectomized rats for 28 days only to little extent decreased the development of osteopenic skeletal changes which were caused by bilateral ovariectomy. alpha-Escin (35 mg/kg po, daily) administered to the sham operated rats for 28 days caused slight changes in the skeletal system, which were characterized by the increase in the bone formation processes. Key words: alpha-escin, bone, ovariectomized rats, osteopenia |
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