Copyright © 1999 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 1999, 51, 119-123
ISSN 1230-6002
Go to: Contents | Previous Article | Next Article | PJP - Home Page |


ALCOHOL INTAKE AND BRAIN [3H]MUSCIMOL BINDING SITES IN ALCOHOL-PREFERRING AND NON-PREFERRING RATS
 Wanda Dyr1, Marek Siemiątkowski1, Adam Płaźnik1,3, Andrzej Bidziński2, Wojciech Kostowski1,3,#
 1 Department of Pharmacology and Physiology of the Nervous System,
2 Department of Biochemistry, Institute of Psychiatry and Neurology, Sobieskiego 1/9, PL 02-957 Warszawa, Poland,
3 Department of Pharmacology, Medical Academy, Krakowskie Przedmieście 26/28, PL 00-927 Warszawa, Poland

Alcohol intake and brain [3H]muscimol binding sites in alcohol-preferring and non-preferring rats. W. DYR, M. SIEMIĄTKOWSKI, A. PŁAŹNIK, A. BIDZIŃSKI, W. KOSTOWSKI. Pol. J. Pharmacol., 1999, 51, 119-123.

The present study has employed in vitro autoradiography to determine the distribution and density of [3H]muscimol binding sites in the brains of alcohol high-preferring line of rats (WHP) and alcohol low-preferring line of rats (WLP). While the density of [3H]muscimol binding was found to be similar in the frontal cortex, caudate-putamen, nucleus accumbens, lateral and medial septum, the density of [3H]muscimol binding was lower in cingulate cortex of alcohol low-preferring rats as compared to alcohol high preferring rats. Moreover, the density of muscimol binding sites within this area was positively correlated with the intensity of ethanol consumption.

Key words: [3H]muscimol, autoradiography, alcohol, alcohol-preferring rats, GABA-A receptors
  # correspondence
Back to: Top | PJP - Home Page |