Copyright © 1999 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 1999, 51, 443-447
ISSN 1230-6002
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SHORT COMMUNICATION
 L-N6-(1-IMINOETHYL)-LYSINE (L-NIL) BUT NOT S-METHYLISOTHIOUREA SULPHATE (SMT) DISPLAYS SELECTIVITY TOWARDS NOS-2
 Stefan Ch³opicki#, Rafa³ Olszanecki, Andrzej Jakubowski, Magdalena £omnicka, Ryszard J. Gryglewski
 Department of Pharmacology, Jagiellonian University, Medical College, Grzegórzecka 16, PL 31-531, Kraków, Poland

L-N6-(1-iminoethyl)-lysine (L-NIL) but not S-methylisothiourea sulphate (SMT) displays selectivity towards NOS-2. S. CH£OPICKI, R. OLSZANECKI, A. JAKUBOWSKI, M. £OMNICKA. R.J. GRYGLEWSKI. Pol. J. Pharmacol., 1999, 51, 443-447.

Our aim was to verify potency and selectiveness of two most widely used drugs regarded as NOS-2 inhibitors: L-N6-(1-iminoethyl)-lysine (L-NIL) and S-methylisothiourea sulphate (SMT). Thioglycolate-elicited rat peritoneal macrophages and coronary endothelium of isolated guinea pig heart were used as assay systems for NOS-2 and NOS-3, respectively. A non-selective NOS inhibitor, NG-nitro-L-arginine methyl ester (L-NAME) was used as a reference compound. We found that L-NIL but not SMT was a selective NOS-2 inhibitor. Interestingly, L-NAME displayed selectivity towards NOS-3.

Key words: selective NOS-2 inhibitors, macrophages, endothelium, L-NAME, SMT, L-NIL
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