Laboratory of Biochemical Pharmacology
Welcome to the website of the Laboratory of Biochemical Pharmacology. We are part of the Department of Pharmacology, Maj Institute of Pharmacology, Polish Academy of Sciences in Krakow. Our team consists of people with different educational backgrounds, who share a passion for discovering the mechanisms of the action of drugs. The subject of our preclinical research concerns the mechanism of action of psychoactive drugs, especially antidepressants and antipsychotics in the context of drug resistance.
Research methods and models used in our Laboratory are very advanced, diverse, and constantly developed - from cell cultures to transgenic animals, from radioisotope techniques (saturation and competition analyses, receptor autoradiography) to studies of receptor protein interactions in the brain using the PLA technique, in situ hybridization, RT-PCR and miRNA measurements; basically, it's hard to list them all.
Our strength is an excellent well-coordinated team, interdisciplinary and closely cooperating, which means that no new technique is difficult for us.
In November 2022, a team has been awarded the Division V of Medical Sciences of the Polish Academy of Sciences for a series of publications: "Determination of the role of selected microRNAs as biomarkers of stress resilience".
To find out more about the life of our Lab, please visit our blog
Laboratory of Biochemical Pharmacology PAS (goreckalab.blogspot.com)
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Agata Kowalik, Mateusz Majerek, Krzysztof Mrowiec, Joanna Solich, Agata Faron-Górecka, Olga Woźnicka, Marta Dziedzicka-Wasylewska, Sylwia Łukasiewicz
Biomolecules, 749 10.3390/biom12060749
PMID:35740874 -
Pro-cognitive effect of acute imipramine administration correlates with direct interaction of BDNF with its receptor, Trkβ.
Agata Faron-Górecka, Maciej Kuśmider, Piotr Gruca, Paulina Pabian, Agata Korlatowicz, Joanna Solich, Magdalena Kolasa, Marta Dziedzicka-Wasylewska
Brain research, S0006-8993(22)00172-X 10.1016/j.brainres.2022.147948
PMID:35597327 -
Identification of Molecular Markers of Clozapine Action in Ketamine-Induced Cognitive Impairment: A GPCR Signaling PathwayFinder Study.
Agata Korlatowicz, Maciej Kuśmider, Marta Szlachta, Paulina Pabian, Joanna Solich, Marta Dziedzicka-Wasylewska, Agata Faron-Górecka
International journal of molecular sciences, 12203 10.3390/ijms222212203
PMID:34830086 -
MicroRNA Let-7e in the Mouse Prefrontal Cortex Differentiates Restraint-Stress-Resilient Genotypes from Susceptible Genotype.
Joanna Solich, Magdalena Kolasa, Agata Faron-Górecka, Jacek Hajto, Marcin Piechota, Marta Dziedzicka-Wasylewska
International journal of molecular sciences, 9439 10.3390/ijms22179439
PMID:34502349 -
What Do the Animal Studies of Stress Resilience Teach Us?
Marta Dziedzicka-Wasylewska, Joanna Solich, Agata Korlatowicz, Agata Faron-Górecka
Cells, 1630 10.3390/cells10071630
PMID:34209787 -
Repeated treatment with alpha 7 nicotinic acetylcholine receptor ligands enhances cognitive processes and stimulates Erk1/2 and Arc genes in rats.
Agnieszka Potasiewicz, Agata Faron-Gorecka, Piotr Popik, Agnieszka Nikiforuk
Behavioural brain research, S0166-4328(21)00226-6 10.1016/j.bbr.2021.113338
PMID:33940049 -
Restraint Stress in Mice Alters Set of 25 miRNAs Which Regulate Stress- and Depression-Related mRNAs.
Joanna Solich, Maciej Kuśmider, Agata Faron-Górecka, Paulina Pabian, Marta Dziedzicka-Wasylewska
International journal of molecular sciences, E9469 10.3390/ijms21249469
PMID:33322800 -
Time-course of changes in key catecholaminergic receptors and trophic systems in rat brain after antidepressant administration.
M Kusmider, A Faron-Górecka, J Solich, P Pabian, M Dziedzicka-Wasylewska
Neurochemistry international, S0197-0186(20)30276-X 10.1016/j.neuint.2020.104885
PMID:33132141 -
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Grzegorz Burnat, Piotr Brański, Joanna Solich, Magdalena Kolasa, Barbara Chruścicka, Marta Dziedzicka-Wasylewska, Andrzej Pilc
Pharmacological reports : PR, 10.1007/s43440-020-00114-1
PMID:32472388 -
Serum Level of miR-1 and miR-155 as Potential Biomarkers of Stress-Resilience of NET-KO and SWR/J Mice.
Joanna Solich, Maciej Kuśmider, Agata Faron-Górecka, Paulina Pabian, Magdalena Kolasa, Beata Zemła, Marta Dziedzicka-Wasylewska
Cells, E917 10.3390/cells9040917
PMID:32283635 -
Genetic variants in dopamine receptors influence on heterodimerization in the context of antipsychotic drug action.
Agata Faron-Górecka, Maciej Kuśmider, Joanna Solich, Andrzej Górecki, Marta Dziedzicka-Wasylewska
Progress in molecular biology and translational science, S1877-1173(19)30205-4 10.1016/bs.pmbts.2019.11.008
PMID:31952689 -
Genomic Screening of Wistar and Wistar-Kyoto Rats Exposed to Chronic Mild Stress and Deep Brain Stimulation of Prefrontal Cortex.
Mariusz Papp, Piotr Gruca, Agata Faron-Górecka, Maciej Kusmider, Paul Willner
Neuroscience, S0306-4522(19)30702-X 10.1016/j.neuroscience.2019.10.015
PMID:31705885 -
Effects on brain-derived neurotrophic factor signalling of chronic mild stress, chronic risperidone and acute intracranial dopamine receptor challenges.
Mariusz Papp, Piotr Gruca, Magdalena Lason-Tyburkiewicz, Ewa Litwa, Monika Niemczyk, Katarzyna Tota-Glowczyk, Agata Faron-Gorecka, Maciej Kusmider, Joanna Solich, Marta Szlachta, Paul Willner
Behavioural pharmacology, 10.1097/FBP.0000000000000392
PMID:29537988 -
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Marta Szlachta, Maciej Kuśmider, Joanna Solich, Magdalena Kolasa, Paulina Pabian, Marta Dziedzicka-Wasylewska, Agata Faron-Górecka
Neuroscience letters, S0304-3940(19)30365-9 10.1016/j.neulet.2019.134292
PMID:31132389 -
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Dawid Gawliński, Irena Smaga, Magdalena Zaniewska, Kinga Gawlińska, Agata Faron-Górecka, Małgorzata Filip
Pharmacological reports : PR, S1734-1140(19)30065-9 10.1016/j.pharep.2019.05.012
PMID:31546158
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1. Faron-Górecka A, Szafran-Pilch K. (2016) Prolactin and Somatostatin Responses to Antidepressant Therapy. In: López-Muñoz F., Srinivasan V., de Berardis D., Álamo C., Kato T. (eds) Melatonin, Neuroprotective Agents and Antidepressant Therapy. Springer, N
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Understanding GPCR dimerization. Methods in Cell Biology, Elsevier https://doi.org/10.1016/bs.mcb.2018.08.005
Faron-Górecka A, Kuśmider M, Solich J, Górecki A, Dziedzicka-Wasylewska M. (2020) Genetic variants in dopamine receptors influence on heterodimerization in the context of antipsychotic drug action. Progress in Molecular Biology and Translational Science, Elsevier https://doi.org/10.1016/bs.pmbts.2019.11.008
Faron-Górecka A, Szlachta M, Kolasa M, Solich J, Górecki A, Kuśmider M, Żurawek D, Dziedzicka-Wasylewska M. (2019) Understanding GPCR dimerization. Methods in Cell Biology, Elsevier https://doi.org/10.1016/bs.mcb.2018.08.005
Faron-Górecka A, Szafran-Pilch K. (2016) Prolactin and Somatostatin Responses to Antidepressant Therapy. In: López-Muñoz F., Srinivasan V., de Berardis D., Álamo C., Kato T. (eds) Melatonin, Neuroprotective Agents and Antidepressant Therapy. Springer, New Delhi
Zurawek D., Faron-Górecka A, Kuśmider M, Solich J, Kolasa M, Szafran-Pilch K, Kmiotek K, Gruca P, Papp M, Dziedzicka-Wasylewska M. (2015) Dopamine D1 and D2 Receptors in Chronic Mild Stress: Analysis of Dynamic Receptor Changes in an Animal Model of Depression Using In Situ Hybridization and Autoradiography. In: Tiberi M. (eds) Dopamine Receptor Technologies. Neuromethods, vol 96. Humana Press, New York, NY
Łukasiewicz S, Faron-Górecka A, Dziedzicka-Wasylewska M. (2013) A Biophysical Approach for the Study of Dopamine Receptor Oligomerization. In: Kabbani N. (eds) Dopamine. Methods in Molecular Biology (Methods and Protocols), vol 964. Humana Press, Totowa, NJ
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NCN OPUS 8 Molecular mechanism of the unique action of clozapine in the context of heterodimerization of receptors associated with G proteins., Agata Faron - Górecka, PhD
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Endogenous markers of the effectiveness of depression therapy in the model of chronic mild stress (CMS). , Agata Faron - Górecka, PhD
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, Professor Marta Dziedzicka - Wasylewska, PhD
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, Professor Marta Dziedzicka - Wasylewska, PhD
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, Professor Marta Dziedzicka - Wasylewska, PhD
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, Professor Marta Dziedzicka - Wasylewska, PhD
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, Professor Marta Dziedzicka - Wasylewska, PhD
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, Professor Marta Dziedzicka - Wasylewska, PhD
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, Professor Marta Dziedzicka - Wasylewska, PhD
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, Professor Marta Dziedzicka - Wasylewska, PhD
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, Professor Marta Dziedzicka - Wasylewska, PhD
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Scientific Award of the Faculty of Medical Sciences of the Polish Academy of Sciences: prof dr hab. Marta Dziedzicka-Wasylewska, dr hab. Agata Faron-Górecka, dr Joanna Solich, Agata Faron - Górecka, PhD
Thursday, 17 November 2022 -
FNP scholarship for young scientists (START Program), Agata Faron - Górecka, PhD
Saturday, 26 April 2008 -
FNP scholarship for young scientists (START Program), Agata Faron - Górecka, PhD
Saturday, 21 April 2007 -
ECNP Travel Award - ECNP Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nicea, France, Agata Faron - Górecka, PhD
Thursday, 9 March 2006 -
ECNP Travel Award - ECNP Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nicea, France, Agata Faron - Górecka, PhD
Saturday, 8 March 0200 -
, Professor Marta Dziedzicka - Wasylewska, PhD
Monday, 30 November -0001
interests
techniques
keywords
- antidepressants
- antipsychotics
- axonal transport
- behavioural analysis
- biomarker
- depression
- G-protein coupled receptors
- gene expression
- gene expression profiling
- immobilization stress
- miRNA
- molecular biology
- mouse
- neuropeptides
- psychopharmacology
- schizophrenia
- second messengers
- stress
- treatment-resistant depression