Affective Cognitive Neuroscience Laboratory
Affective Cognitive Neuroscience Lab was established in 2013 as subdivision of the Department of Behavioural Neuroscience and Drug Development at the Institute of Pharmacology Polish Academy of Sciences. In 2017 the laboratory has been associated with the Department of Pharmacology. Our main research activity is aimed at investigation of the phharmacological, neuroanatomical and neurochemical correlates of cognitive processing biases in animal models.
People in the lab:Dr hab Rafał Ryguła- P.I.
and the team:
Karolina Noworyta Sokołowska PhD
Paulina Surówka
alumni:
Robert Drozd PhD
Anna Kozub MSc
Michał Rychlik MSc
Joanna Golebiowska MSc
Karolina Rojek MSc
Jakub Kubik
Arkadiusz Liśkiewicz PhD
Jakub Kręgiel MSc
Justyna Papciak MSc
Marta Lemieszewska MSc
Ewa Szczech
Interesting links:
https://www.wsj.com/articles/for-rats-a-good-tickling-can-change-the-world-1468530323
http://www.usatoday.com/story/news/2015/07/28/hamster-mood-angry-study/30803989/
http://www.wsj.com/articles/for-rats-a-good-tickling-can-change-the-world-1468530323
https://digest.bps.org.uk/2016/06/30/pessimistic-rats-are-extra-sensitive-to-negative-feedback/
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Sensitivity to negative and positive feedback as a stable and enduring behavioural trait in rats.
Karolina Noworyta-Sokolowska, Anna Kozub, Judyta Jablonska, Jan Rodriguez Parkitna, Robert Drozd, Rafal Rygula
Psychopharmacology, 10.1007/s00213-019-05333-w
PMID:31375849 -
Using rodents to model abnormal sensitivity to feedback in depression.
Rafal Rygula, Karolina Noworyta-Sokolowska, Robert Drozd, Anna Kozub
Neuroscience and biobehavioral reviews, S0149-7634(18)30342-7 10.1016/j.neubiorev.2018.10.008
PMID:30347197 -
Effects of cognitive judgement bias and acute antidepressant treatment on sensitivity to feedback and cognitive flexibility in the rat version of the probabilistic reversal-learning test.
Robert Drozd, Michal Rychlik, Agata Fijalkowska, Rafal Rygula
Behavioural brain research, S0166-4328(18)31081-7 10.1016/j.bbr.2018.10.003
PMID:30292902 -
The trait 'pessimism' does not interact with cognitive flexibility but makes rats more vulnerable to stress-induced motivational deficits: Results from the attentional set-shifting task.
Robert Drozd, Karolina Rojek-Sito, Rafal Rygula
Behavioural brain research, S0166-4328(17)31141-5 10.1016/j.bbr.2017.08.028
PMID:28842268 -
The effects of pessimism on cell-mediated immunity in rats.
Katarzyna Curzytek, Marta Kubera, Ewa Trojan, Kinga Wójcik, Agnieszka Basta-Kaim, Jan Detka, Michael Maes, Rafal Rygula
Progress in neuro-psychopharmacology & biological psychiatry, S0278-5846(17)30059-3 10.1016/j.pnpbp.2017.04.034
PMID:28595946 -
Lesions of the Orbitofrontal but Not Medial Prefrontal Cortex Affect Cognitive Judgment Bias in Rats.
Joanna Golebiowska, Rafal Rygula
Frontiers in behavioral neuroscience, 10.3389/fnbeh.2017.00051
PMID:28377703 -
Effects of acute dopaminergic and serotonergic manipulations in the ACI paradigm depend on the basal valence of cognitive judgement bias in rats.
Joanna Golebiowska, Rafal Rygula
Behavioural brain research, S0166-4328(16)31261-X 10.1016/j.bbr.2017.02.013
PMID:28212943 -
Measuring Cognitive Judgement Bias in Rats Using the Ambiguous-Cue Interpretation Test.
Justyna Papciak, Rafal Rygula
Current protocols in neuroscience, 10.1002/cpns.19
PMID:28046201 -
Ketamine decreases sensitivity of male rats to misleading negative feedback in a probabilistic reversal-learning task.
Michal Rychlik, Eva Bollen, Rafal Rygula
Psychopharmacology,
PMID:27933365 -
Cognitive Judgment Bias Interacts with Risk Based Decision Making and Sensitivity to Dopaminergic Challenge in Male Rats.
Robert Drozd, Przemyslaw E Cieslak, Michal Rychlik, Jan Rodriguez Parkitna, Rafal Rygula
Frontiers in behavioral neuroscience, 10.3389/fnbeh.2016.00163
PMID:27601984 -
Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in Rats.
Karolina Noworyta-Sokołowska, Katarzyna Kamińska, Grzegorz Kreiner, Zofia Rogóż, Krystyna Gołembiowska
Neurotoxicity research,
PMID:27461536 -
Neurochemical and behavioral studies on the 5-HT1A-dependent antipsychotic action of the mGlu4 receptor agonist LSP4-2022.
Monika Woźniak, Krystyna Gołembiowska, Karolina Noworyta-Sokołowska, Francine Acher, Paulina Cieślik, Magdalena Kusek, Krzysztof Tokarski, Andrzej Pilc, Joanna M Wierońska
Neuropharmacology, S0028-3908(16)30278-7 10.1016/j.neuropharm.2016.06.025
PMID:27465045 -
The influence of aripiprazole and olanzapine on neurotransmitters level in frontal cortex of prenatally stressed rats.
P Ratajczak, K Kus, K Gołembiowska, K Noworyta-Sokołowska, A Woźniak, T Zaprutko, E Nowakowska
Environmental toxicology and pharmacology, S1382-6689(16)30185-5 10.1016/j.etap.2016.07.007
PMID:27458700 -
Trait
Rafal Rygula, Piotr Popik
Cognitive, affective & behavioral neuroscience, 10.3758/s13415-016-0410-y
PMID:26902303 -
Effects of optimism on gambling in the rat slot machine task.
Dominik Rafa, Jakub Kregiel, Piotr Popik, Rafal Rygula
Behavioural brain research, 10.1016/j.bbr.2015.12.013 S0166-4328(15)30327-2
PMID:26698397
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Neurobiology of optimism (article in polish)
The article was published in journal "Wszechświat" and is based on a talk given during the 2014 Brain Awarness Week in Krakow.
http://www.ptpk.org/tydzien_mozgu/tydzien_mozgu_2014.html#art_5
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The role of cognitive bias in individual vulnerability to to the transition from controlled use to uncontrolled abuse of alcohol in an animal model., Rafał Ryguła, PhD
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Neuroscience boat, Rafał Ryguła, PhD
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, Rafał Ryguła, PhD
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Sensitivity to negative feedback as a cognitive biomarker of depression in an animal model, Rafał Ryguła, PhD
Carried out in years 2017 - 2020. Received from Polish National Science Centre as a part of OPUS 12 program.
P.I.: Rafal Rygula
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Pessimism as a cognitive biomarker of depressive disorder in an animal model (Grant NCN DEC-2014/13/B/NZ4/00214), Rafał Ryguła, PhD
Research conducted in years 2015-2018. Received within the programme OPUS 7 by the Polish National Centre for Science.
P.I.:Rafał Ryguła
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, Rafał Ryguła, PhD
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, Rafał Ryguła, PhD
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, Rafał Ryguła, PhD
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Prime Minister's award for habilitation, Rafał Ryguła, PhD
Thursday, 24 November 2016
techniques
- ambiguous-cue interpretation test
- analysis of ultrasonic vocalisations
- apoptosis
- chronic psychosocial stress
- excitotoxic lesions
- forced swim test
- head twitches test
- HPLC EC
- HPLC UV
- immobilisation stress
- microdialysis in vitro
- microinjections
- open field test
- probabilistic reversal learning
- rat Slot Machine Task
- reversal learning
- stereotactic implantation of cannulas
- sucrose preference test
keywords
- 5,7-DHT
- 6-OHDA
- adenosine
- adenosine receptors
- allosteric modulation
- amphetamine
- animal models
- aripiprazole
- dopamine
- drug addiction
- feedback sensitivity
- frontal cortex
- GABA
- glia
- glutamate
- glutamatergic receptors
- immobilization stress
- judgment bias
- laughter
- MDMA
- monoamines
- neurodegeneration
- neuroprotection
- neurotoxicity
- nigro-striatal dopaminergic system
- noradrenaline
- Parkinson's disease
- prefrontal cortex
- probabilistic reversal learning
- psychopharmacology
- psychosocial stress
- rat
- safety signals
- serial reversal learning
- serotonin
- serotonin receptors
- stress
- striatum
- tickling
