Affective Cognitive Neuroscience Laboratory

Affective Cognitive Neuroscience Lab was established in 2013 as subdivision of the Department of Behavioural Neuroscience and Drug Development at the Institute of Pharmacology Polish Academy of Sciences. In 2017 the laboratory has been associated with the Department of Pharmacology. Our main research activity is aimed at investigation of the behavioural, pharmacological, neuroanatomical and neurochemical correlates of cognitive processing biases in animal models.

People in the lab:
Dr hab Rafał Ryguła- P.I.

and the team:

Karolina Noworyta Sokołowska, PhD

Paulina Surówka, MSc

Agata Cieślik, MSc

alumni:

Robert Drozd PhD

Anna Kozub MSc

Michał Rychlik MSc

Joanna Golebiowska MSc

Karolina Rojek MSc

Jakub Kubik

Arkadiusz Liśkiewicz PhD

Jakub Kręgiel MSc

Justyna Papciak MSc

Marta Lemieszewska MSc

Ewa Szczech

Interesting links:

https://www.wsj.com/articles/for-rats-a-good-tickling-can-change-the-world-1468530323

http://naukawpolsce.pap.pl/aktualnosci/news,410967,szczurzy-pesymisci-pomagaja-zrozumiec-depresje.html

http://www.usatoday.com/story/news/2015/07/28/hamster-mood-angry-study/30803989/

http://www.wsj.com/articles/for-rats-a-good-tickling-can-change-the-world-1468530323

https://digest.bps.org.uk/2016/06/30/pessimistic-rats-are-extra-sensitive-to-negative-feedback/

Chronic Psychosocial Stress Causes Increased Anxiety-Like Behavior and Alters Endocannabinoid Levels in the Brain of C57Bl/6J Mice. Yvonne Bouter, Magdalena M Brzózka, Rafal Rygula, Franziska Pahlisch, F Markus Leweke, Ursula Havemann-Reinecke, Cathrin Rohleder
Cannabis and cannabinoid research, 10.1089/can.2019.0041
PMID:32322676
Sensitivity to negative and positive feedback as a stable and enduring behavioural trait in rats. Karolina Noworyta-Sokolowska, Anna Kozub, Judyta Jablonska, Jan Rodriguez Parkitna, Robert Drozd, Rafal Rygula
Psychopharmacology, 10.1007/s00213-019-05333-w
PMID:31375849
Using rodents to model abnormal sensitivity to feedback in depression. Rafal Rygula, Karolina Noworyta-Sokolowska, Robert Drozd, Anna Kozub
Neuroscience and biobehavioral reviews, S0149-7634(18)30342-7 10.1016/j.neubiorev.2018.10.008
PMID:30347197
Effects of cognitive judgement bias and acute antidepressant treatment on sensitivity to feedback and cognitive flexibility in the rat version of the probabilistic reversal-learning test. Robert Drozd, Michal Rychlik, Agata Fijalkowska, Rafal Rygula
Behavioural brain research, S0166-4328(18)31081-7 10.1016/j.bbr.2018.10.003
PMID:30292902
The trait 'pessimism' does not interact with cognitive flexibility but makes rats more vulnerable to stress-induced motivational deficits: Results from the attentional set-shifting task. Robert Drozd, Karolina Rojek-Sito, Rafal Rygula
Behavioural brain research, S0166-4328(17)31141-5 10.1016/j.bbr.2017.08.028
PMID:28842268
The effects of pessimism on cell-mediated immunity in rats. Katarzyna Curzytek, Marta Kubera, Ewa Trojan, Kinga Wójcik, Agnieszka Basta-Kaim, Jan Detka, Michael Maes, Rafal Rygula
Progress in neuro-psychopharmacology & biological psychiatry, S0278-5846(17)30059-3 10.1016/j.pnpbp.2017.04.034
PMID:28595946
Lesions of the Orbitofrontal but Not Medial Prefrontal Cortex Affect Cognitive Judgment Bias in Rats. Joanna Golebiowska, Rafal Rygula
Frontiers in behavioral neuroscience, 10.3389/fnbeh.2017.00051
PMID:28377703
Effects of acute dopaminergic and serotonergic manipulations in the ACI paradigm depend on the basal valence of cognitive judgement bias in rats. Joanna Golebiowska, Rafal Rygula
Behavioural brain research, S0166-4328(16)31261-X 10.1016/j.bbr.2017.02.013
PMID:28212943
Measuring Cognitive Judgement Bias in Rats Using the Ambiguous-Cue Interpretation Test. Justyna Papciak, Rafal Rygula
Current protocols in neuroscience, 10.1002/cpns.19
PMID:28046201
Ketamine decreases sensitivity of male rats to misleading negative feedback in a probabilistic reversal-learning task. Michal Rychlik, Eva Bollen, Rafal Rygula
Psychopharmacology,
PMID:27933365
Cognitive Judgment Bias Interacts with Risk Based Decision Making and Sensitivity to Dopaminergic Challenge in Male Rats. Robert Drozd, Przemyslaw E Cieslak, Michal Rychlik, Jan Rodriguez Parkitna, Rafal Rygula
Frontiers in behavioral neuroscience, 10.3389/fnbeh.2016.00163
PMID:27601984
Neurotoxic Effects of 5-MeO-DIPT: A Psychoactive Tryptamine Derivative in Rats. Karolina Noworyta-Sokołowska, Katarzyna Kamińska, Grzegorz Kreiner, Zofia Rogóż, Krystyna Gołembiowska
Neurotoxicity research,
PMID:27461536
Neurochemical and behavioral studies on the 5-HT1A-dependent antipsychotic action of the mGlu4 receptor agonist LSP4-2022. Monika Woźniak, Krystyna Gołembiowska, Karolina Noworyta-Sokołowska, Francine Acher, Paulina Cieślik, Magdalena Kusek, Krzysztof Tokarski, Andrzej Pilc, Joanna M Wierońska
Neuropharmacology, S0028-3908(16)30278-7 10.1016/j.neuropharm.2016.06.025
PMID:27465045
The influence of aripiprazole and olanzapine on neurotransmitters level in frontal cortex of prenatally stressed rats. P Ratajczak, K Kus, K Gołembiowska, K Noworyta-Sokołowska, A Woźniak, T Zaprutko, E Nowakowska
Environmental toxicology and pharmacology, S1382-6689(16)30185-5 10.1016/j.etap.2016.07.007
PMID:27458700
Trait Rafal Rygula, Piotr Popik
Cognitive, affective & behavioral neuroscience, 10.3758/s13415-016-0410-y
PMID:26902303

More publications

Neurobiology of optimism (article in polish) The article was published in journal "Wszechświat" and is based on a talk given during the 2014 Brain Awarness Week in Krakow.
http://www.ptpk.org/tydzien_mozgu/tydzien_mozgu_2014.html#art_5

More publications

#Webimmunization. How can online social networks create collective resilience against misinformation?”, Rafał Ryguła, PhD
The role of cognitive bias in individual vulnerability to to the transition from controlled use to uncontrolled abuse of alcohol in an animal model., Rafał Ryguła, PhD
Neuroscience boat, Rafał Ryguła, PhD
, Rafał Ryguła, PhD
Sensitivity to negative feedback as a cognitive biomarker of depression in an animal model, Rafał Ryguła, PhD
Carried out in years 2017 - 2020. Received from Polish National Science Centre as a part of OPUS 12 program.
P.I.: Rafal Rygula
Pessimism as a cognitive biomarker of depressive disorder in an animal model (Grant NCN DEC-2014/13/B/NZ4/00214), Rafał Ryguła, PhD
Research conducted in years 2015-2018. Received within the programme OPUS 7 by the Polish National Centre for Science.
P.I.:Rafał Ryguła
, Rafał Ryguła, PhD
, Rafał Ryguła, PhD
, Rafał Ryguła, PhD
, Rafał Ryguła, PhD
, Rafał Ryguła, PhD

more_grants

Prime Minister's award for habilitation, Rafał Ryguła, PhD
Thursday, 24 November 2016

more_awards

Head

Rafał Ryguła, PhD

Phone number: +48 12 6623373
E-mail: rygula@gmail.com

Affective Cognitive Neuroscience Laboratory

Rafał Ryguła, PhD

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