Department of Brain Biochemistry
[Site under construction]
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The Protective Effect of Repeated 1MeTIQ Administration on the Lactacystin-Induced Impairment of Dopamine Release and Decline in TH Level in the Rat Brain.
Agnieszka Wąsik, Irena Romańska, Agnieszka Zelek-Molik, Irena Nalepa, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-018-9939-6
PMID:30129004 -
Involvement of Macrophage Inflammatory Protein-1 Family Members in the Development of Diabetic Neuropathy and Their Contribution to Effectiveness of Morphine.
Ewelina Rojewska, Magdalena Zychowska, Anna Piotrowska, Grzegorz Kreiner, Irena Nalepa, Joanna Mika
Frontiers in immunology, 10.3389/fimmu.2018.00494
PMID:29593735 -
Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects.
Paweł Zajdel, Tomasz Kos, Krzysztof Marciniec, Grzegorz Satała, Vittorio Canale, Krzysztof Kamiński, Małgorzata Hołuj, Tomasz Lenda, Robert Koralewski, Marek Bednarski, Leszek Nowiński, Jacek Wójcikowski, Władysława A Daniel, Agnieszka Nikiforuk, Irena Nalepa, Piotr Chmielarz, Justyna Kuśmierczyk, Andrzej J Bojarski, Piotr Popik
European journal of medicinal chemistry, S0223-5234(18)30002-3 10.1016/j.ejmech.2018.01.002
PMID:29407591 -
Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test.
Katarzyna Rafa-Zabłocka, Grzegorz Kreiner, Monika Bagińska, Justyna Kuśmierczyk, Rosanna Parlato, Irena Nalepa
Scientific reports, 10.1038/s41598-017-14069-6
PMID:29044198 -
Spinal CCL1/CCR8 signaling interplay as a potential therapeutic target - Evidence from a mouse diabetic neuropathy model.
Magdalena Zychowska, Ewelina Rojewska, Anna Piotrowska, Grzegorz Kreiner, Irena Nalepa, Joanna Mika
International immunopharmacology, S1567-5769(17)30360-0 10.1016/j.intimp.2017.09.021
PMID:28961489 -
Assessment of leukocyte activity in mice devoid of the glucocorticoid receptor in the noradrenergic system (GRDBHCre).
Adam Roman, Justyna Kuśmierczyk, Grzegorz Kreiner, Irena Nalepa
Immunobiology, S0171-2985(17)30163-8 10.1016/j.imbio.2017.10.022
PMID:29030008 -
Dicer and microRNAs protect adult dopamine neurons.
Piotr Chmielarz, Julia Konovalova, Syeda Sadia Najam, Heike Alter, Timo Petteri Piepponen, Holger Erfle, Kai C Sonntag, Günther Schütz, Ilya A Vinnikov, Andrii Domanskyi
Cell death & disease, 10.1038/cddis.2017.214
PMID:28542144 -
Suppression of pro-inflammatory cytokine expression and lack of anti-depressant-like effect of fluoxetine in lipopolysaccharide-treated old female mice.
Weronika Duda, Marta Kubera, Grzegorz Kreiner, Katarzyna Curzytek, Jan Detka, Katarzyna Głombik, Joanna Ślusarczyk, Agnieszka Basta-Kaim, Bogusława Budziszewska, Władysław Lasoń, Magdalena Regulska, Monika Leśkiewicz, Adam Roman, Agnieszka Zelek-Molik, Irena Nalepa
International immunopharmacology, S1567-5769(17)30155-8 10.1016/j.intimp.2017.04.021
PMID:28460354 -
Lack of riluzole efficacy in the progression of the neurodegenerative phenotype in a new conditional mouse model of striatal degeneration.
Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Piotr Chmielarz, Monika Bagińska, Irena Nalepa
PeerJ, 10.7717/peerj.3240
PMID:28462043 -
Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling.
Malgorzata Kajta, Agnieszka Wnuk, Joanna Rzemieniec, Ewa Litwa, Wladyslaw Lason, Agnieszka Zelek-Molik, Irena Nalepa, Zofia Rogóż, Adam Grochowalski, Anna K Wojtowicz
The Journal of steroid biochemistry and molecular biology, S0960-0760(17)30066-3 10.1016/j.jsbmb.2017.03.001
PMID:28263910 -
The Slavery of the h-index-Measuring the Unmeasurable.
Grzegorz Kreiner
Frontiers in human neuroscience,
PMID:27853429 -
A lack of α1A-adrenergic receptor-mediated antidepressant-like effects of S-(+)-niguldipine and B8805-033 in the forced swim test.
Grzegorz Kreiner, Adam Roman, Agnieszka Zelek-Molik, Marta Kowalska, Irena Nalepa
Behavioural pharmacology, 10.1097/FBP.0000000000000204
PMID:26588212 -
Erratum to: Neuroprotective Effect of the Endogenous Amine 1MeTIQ in an Animal Model of Parkinson's Disease.
Agnieszka Wasik, Irena Romańska, Jerzy Michaluk, Agnieszka Zelek-Molik, Irena Nalepa, Lucyna Antkiewicz-Michaluk
Neurotoxicity research,
PMID:27106849 -
Depressive-like immobility behavior and genotype × stress interactions in male mice of selected strains.
Piotr Chmielarz, Grzegorz Kreiner, Justyna Kuśmierczyk, Marta Kowalska, Adam Roman, Katarzyna Tota, Irena Nalepa
Stress (Amsterdam, Netherlands), 10.3109/10253890.2016.1150995
PMID:26941077 -
Neuroprotective Effect of the Endogenous Amine 1MeTIQ in an Animal Model of Parkinson's Disease.
Agnieszka Wąsik, Irena Romańska, Jerzy Michaluk, Agnieszka Zelek-Molik, Irena Nalepa, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-015-9556-6
PMID:26303030
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Evaluation of the influence of progressive noradrenergic neurodegeneration on dopaminergic system functioning in context of presymptomatic phase of Parkinson's disease., Grzegorz Kreiner, PhD
OPUS13 2017/25/B/NZ7/02406
Principal Investigator: Dr Grzegorz Kreiner -
, Professor Irena Nalepa, PhD
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, Professor Irena Nalepa, PhD
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Evaluation of the role of transcription factor CREB in the mechanisms antidepressant treatment, Grzegorz Kreiner, PhD
OPUS7 2014/13/B/NZ7/02293
Principal Investigator: Dr Grzegorz Kreiner -
Pharmacological evaluation of possible neuroprotective strategies in novel genetic mouse models of progressive neurodegeneration, based on tissue specific inducible Cre/loxP system , Grzegorz Kreiner, PhD
OPUS2 2011/03/B/NZ7/05949
Principal Investigator: Dr Grzegorz Kreiner
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, Professor Irena Nalepa, PhD
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, Adam Roman, PhD
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Investigation of noradrenergic and glucocorticoid system interactions in GRDBHCre mice and their evaluation as a potential model of depression, Grzegorz Kreiner, PhD
POIG 01.01.02-12-004/09 DeMeTer (Depression – Mechanisms – Therapy).
Task 1.1 Subtask 1.1.2. Main topic: Modelling of depression – strategy of learning about its aetiology. Principal Investigator of task 1.2: Dr Grzegorz Kreiner
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, Professor Irena Nalepa, PhD
interests
techniques
- cDNA microarrays
- chronic mild stress
- colorometric evaluation of macrophage activity
- electroconvulsive therapy
- electrophoresis
- ELISA
- flow cytometry
- forced swim test
- genotyping
- HTRF
- immobilisation stress
- immune cells tissue cultures
- immunofluorescence
- immunohistochemistry
- in vitro transfection
- mammalian cells tissue cultures
- microinjections
- molecular cloning
- MTT test
- next-generation sequencing
- northern blot
- primary cultures
- protein fractioning
- protein microarrays
- radiologand binding
- Real Time PCR
- spectroscopy UV-VIS
- tail suspension test
- tissue cultures with stable expressing genes encoding selected proteins
- TLDA microarrays
- transgenic models based on conditioned/inducible recombinaze Cre/loxP
- Western Blot
keywords
- animal models
- antidepressants
- apoptosis
- bioinformatics
- cytokines
- depression
- drug addiction
- G-protein coupled receptors
- gene expression
- glia
- glutamate
- hippocampus
- imipramine
- immune system
- macrophages
- molecular biology
- mouse
- neurons
- neuroprotection
- noradrenaline
- prefrontal cortex
- psychopharmacology
- rat
- second messengers
- signaling proteins
- stress
- thalamus
- treatment-resistant depression
