Department of Brain Biochemistry
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Back and to the Future: From Neurotoxin-Induced to Human Parkinson's Disease Models.
Mikko Airavaara, Ilmari Parkkinen, Julia Konovalova, Katrina Albert, Piotr Chmielarz, Andrii Domanskyi
Current protocols in neuroscience, 10.1002/cpns.88
PMID:32049438 -
MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System.
Emmi Pakarinen, Tatiana Danilova, Vootele Võikar, Piotr Chmielarz, Petteri Piepponen, Mikko Airavaara, Mart Saarma, Maria Lindahl
eNeuro, ENEURO.0477-19.2019 10.1523/ENEURO.0477-19.2019
PMID:32005751 -
Interplay between MicroRNAs and Oxidative Stress in Neurodegenerative Diseases.
Julia Konovalova, Dmytro Gerasymchuk, Ilmari Parkkinen, Piotr Chmielarz, Andrii Domanskyi
International journal of molecular sciences, E6055 10.3390/ijms20236055
PMID:31801298 -
Functionally Distinctive Ptch Receptors Establish Multimodal Hedgehog Signaling in the Tooth Epithelial Stem Cell Niche.
Martin Binder, Piotr Chmielarz, Peter J Mckinnon, Leah C Biggs, Irma Thesleff, Anamaria Balic
Stem cells (Dayton, Ohio), 10.1002/stem.3042
PMID:31145830 -
Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism.
Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Justyna Barut, Piotr Chmielarz, Marta Kot, Monika Bagińska, Rosanna Parlato, Władysława Anna Daniel, Irena Nalepa
Scientific reports, 10.1038/s41598-019-41756-3
PMID:30918302 -
Selective Depletion of CREB in Serotonergic Neurons Affects the Upregulation of Brain-Derived Neurotrophic Factor Evoked by Chronic Fluoxetine Treatment.
Katarzyna Rafa-Zabłocka, Grzegorz Kreiner, Monika Bagińska, Irena Nalepa
Frontiers in neuroscience, 10.3389/fnins.2018.00637
PMID:30294251 -
What have we learned recently from transgenic mouse models about neurodegeneration? The most promising discoveries of this millennium.
Grzegorz Kreiner
Pharmacological reports : PR, S1734-1140(17)30841-1 10.1016/j.pharep.2018.09.006
PMID:30312896 -
The Protective Effect of Repeated 1MeTIQ Administration on the Lactacystin-Induced Impairment of Dopamine Release and Decline in TH Level in the Rat Brain.
Agnieszka Wąsik, Irena Romańska, Agnieszka Zelek-Molik, Irena Nalepa, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-018-9939-6
PMID:30129004 -
Involvement of Macrophage Inflammatory Protein-1 Family Members in the Development of Diabetic Neuropathy and Their Contribution to Effectiveness of Morphine.
Ewelina Rojewska, Magdalena Zychowska, Anna Piotrowska, Grzegorz Kreiner, Irena Nalepa, Joanna Mika
Frontiers in immunology, 10.3389/fimmu.2018.00494
PMID:29593735 -
Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects.
Paweł Zajdel, Tomasz Kos, Krzysztof Marciniec, Grzegorz Satała, Vittorio Canale, Krzysztof Kamiński, Małgorzata Hołuj, Tomasz Lenda, Robert Koralewski, Marek Bednarski, Leszek Nowiński, Jacek Wójcikowski, Władysława A Daniel, Agnieszka Nikiforuk, Irena Nalepa, Piotr Chmielarz, Justyna Kuśmierczyk, Andrzej J Bojarski, Piotr Popik
European journal of medicinal chemistry, S0223-5234(18)30002-3 10.1016/j.ejmech.2018.01.002
PMID:29407591 -
Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test.
Katarzyna Rafa-Zabłocka, Grzegorz Kreiner, Monika Bagińska, Justyna Kuśmierczyk, Rosanna Parlato, Irena Nalepa
Scientific reports, 10.1038/s41598-017-14069-6
PMID:29044198 -
Spinal CCL1/CCR8 signaling interplay as a potential therapeutic target - Evidence from a mouse diabetic neuropathy model.
Magdalena Zychowska, Ewelina Rojewska, Anna Piotrowska, Grzegorz Kreiner, Irena Nalepa, Joanna Mika
International immunopharmacology, S1567-5769(17)30360-0 10.1016/j.intimp.2017.09.021
PMID:28961489 -
Assessment of leukocyte activity in mice devoid of the glucocorticoid receptor in the noradrenergic system (GRDBHCre).
Adam Roman, Justyna Kuśmierczyk, Grzegorz Kreiner, Irena Nalepa
Immunobiology, S0171-2985(17)30163-8 10.1016/j.imbio.2017.10.022
PMID:29030008 -
Dicer and microRNAs protect adult dopamine neurons.
Piotr Chmielarz, Julia Konovalova, Syeda Sadia Najam, Heike Alter, Timo Petteri Piepponen, Holger Erfle, Kai C Sonntag, Günther Schütz, Ilya A Vinnikov, Andrii Domanskyi
Cell death & disease, 10.1038/cddis.2017.214
PMID:28542144 -
Suppression of pro-inflammatory cytokine expression and lack of anti-depressant-like effect of fluoxetine in lipopolysaccharide-treated old female mice.
Weronika Duda, Marta Kubera, Grzegorz Kreiner, Katarzyna Curzytek, Jan Detka, Katarzyna Głombik, Joanna Ślusarczyk, Agnieszka Basta-Kaim, Bogusława Budziszewska, Władysław Lasoń, Magdalena Regulska, Monika Leśkiewicz, Adam Roman, Agnieszka Zelek-Molik, Irena Nalepa
International immunopharmacology, S1567-5769(17)30155-8 10.1016/j.intimp.2017.04.021
PMID:28460354
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Evaluation of the influence of progressive noradrenergic neurodegeneration on dopaminergic system functioning in context of presymptomatic phase of Parkinson's disease., Grzegorz Kreiner, PhD
OPUS13 2017/25/B/NZ7/02406
Principal Investigator: Dr Grzegorz Kreiner -
, Professor Irena Nalepa, PhD
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, Professor Irena Nalepa, PhD
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Evaluation of the role of transcription factor CREB in the mechanisms antidepressant treatment, Grzegorz Kreiner, PhD
OPUS7 2014/13/B/NZ7/02293
Principal Investigator: Dr Grzegorz Kreiner -
Pharmacological evaluation of possible neuroprotective strategies in novel genetic mouse models of progressive neurodegeneration, based on tissue specific inducible Cre/loxP system , Grzegorz Kreiner, PhD
OPUS2 2011/03/B/NZ7/05949
Principal Investigator: Dr Grzegorz Kreiner
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, Professor Irena Nalepa, PhD
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, Adam Roman, PhD
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Investigation of noradrenergic and glucocorticoid system interactions in GRDBHCre mice and their evaluation as a potential model of depression, Grzegorz Kreiner, PhD
POIG 01.01.02-12-004/09 DeMeTer (Depression – Mechanisms – Therapy).
Task 1.1 Subtask 1.1.2. Main topic: Modelling of depression – strategy of learning about its aetiology. Principal Investigator of task 1.2: Dr Grzegorz Kreiner
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, Professor Irena Nalepa, PhD
interests
techniques
- cDNA microarrays
- chronic mild stress
- colorometric evaluation of macrophage activity
- electroconvulsive therapy
- electrophoresis
- ELISA
- flow cytometry
- forced swim test
- genotyping
- HTRF
- immobilisation stress
- immune cells tissue cultures
- immunofluorescence
- immunohistochemistry
- in vitro transfection
- mammalian cells tissue cultures
- microinjections
- molecular cloning
- MTT test
- next-generation sequencing
- northern blot
- primary cultures
- protein fractioning
- protein microarrays
- radiologand binding
- Real Time PCR
- spectroscopy UV-VIS
- tail suspension test
- tissue cultures with stable expressing genes encoding selected proteins
- TLDA microarrays
- transgenic models based on conditioned/inducible recombinaze Cre/loxP
- Western Blot
keywords
- animal models
- antidepressants
- apoptosis
- bioinformatics
- cytokines
- depression
- drug addiction
- G-protein coupled receptors
- gene expression
- glia
- glutamate
- hippocampus
- imipramine
- immune system
- macrophages
- molecular biology
- mouse
- neurons
- neuroprotection
- noradrenaline
- prefrontal cortex
- psychopharmacology
- rat
- second messengers
- signaling proteins
- stress
- thalamus
- treatment-resistant depression
