Department of Brain Biochemistry
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Novel multi-target azinesulfonamides of cyclic amine derivatives as potential antipsychotics with pro-social and pro-cognitive effects.
Paweł Zajdel, Tomasz Kos, Krzysztof Marciniec, Grzegorz Satała, Vittorio Canale, Krzysztof Kamiński, Małgorzata Hołuj, Tomasz Lenda, Robert Koralewski, Marek Bednarski, Leszek Nowiński, Jacek Wójcikowski, Władysława A Daniel, Agnieszka Nikiforuk, Irena Nalepa, Piotr Chmielarz, Justyna Kuśmierczyk, Andrzej J Bojarski, Piotr Popik
European journal of medicinal chemistry, S0223-5234(18)30002-3 10.1016/j.ejmech.2018.01.002
PMID:29407591 -
Transgenic mice lacking CREB and CREM in noradrenergic and serotonergic neurons respond differently to common antidepressants on tail suspension test.
Katarzyna Rafa-Zabłocka, Grzegorz Kreiner, Monika Bagińska, Justyna Kuśmierczyk, Rosanna Parlato, Irena Nalepa
Scientific reports, 10.1038/s41598-017-14069-6
PMID:29044198 -
Spinal CCL1/CCR8 signaling interplay as a potential therapeutic target - Evidence from a mouse diabetic neuropathy model.
Magdalena Zychowska, Ewelina Rojewska, Anna Piotrowska, Grzegorz Kreiner, Irena Nalepa, Joanna Mika
International immunopharmacology, S1567-5769(17)30360-0 10.1016/j.intimp.2017.09.021
PMID:28961489 -
Assessment of leukocyte activity in mice devoid of the glucocorticoid receptor in the noradrenergic system (GRDBHCre).
Adam Roman, Justyna Kuśmierczyk, Grzegorz Kreiner, Irena Nalepa
Immunobiology, S0171-2985(17)30163-8 10.1016/j.imbio.2017.10.022
PMID:29030008 -
Dicer and microRNAs protect adult dopamine neurons.
Piotr Chmielarz, Julia Konovalova, Syeda Sadia Najam, Heike Alter, Timo Petteri Piepponen, Holger Erfle, Kai C Sonntag, Günther Schütz, Ilya A Vinnikov, Andrii Domanskyi
Cell death & disease, 10.1038/cddis.2017.214
PMID:28542144 -
Suppression of pro-inflammatory cytokine expression and lack of anti-depressant-like effect of fluoxetine in lipopolysaccharide-treated old female mice.
Weronika Duda, Marta Kubera, Grzegorz Kreiner, Katarzyna Curzytek, Jan Detka, Katarzyna Głombik, Joanna Ślusarczyk, Agnieszka Basta-Kaim, Bogusława Budziszewska, Władysław Lasoń, Magdalena Regulska, Monika Leśkiewicz, Adam Roman, Agnieszka Zelek-Molik, Irena Nalepa
International immunopharmacology, S1567-5769(17)30155-8 10.1016/j.intimp.2017.04.021
PMID:28460354 -
Lack of riluzole efficacy in the progression of the neurodegenerative phenotype in a new conditional mouse model of striatal degeneration.
Grzegorz Kreiner, Katarzyna Rafa-Zabłocka, Piotr Chmielarz, Monika Bagińska, Irena Nalepa
PeerJ, 10.7717/peerj.3240
PMID:28462043 -
Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling.
Malgorzata Kajta, Agnieszka Wnuk, Joanna Rzemieniec, Ewa Litwa, Wladyslaw Lason, Agnieszka Zelek-Molik, Irena Nalepa, Zofia Rogóż, Adam Grochowalski, Anna K Wojtowicz
The Journal of steroid biochemistry and molecular biology, S0960-0760(17)30066-3 10.1016/j.jsbmb.2017.03.001
PMID:28263910 -
The Slavery of the h-index-Measuring the Unmeasurable.
Grzegorz Kreiner
Frontiers in human neuroscience,
PMID:27853429 -
A lack of α1A-adrenergic receptor-mediated antidepressant-like effects of S-(+)-niguldipine and B8805-033 in the forced swim test.
Grzegorz Kreiner, Adam Roman, Agnieszka Zelek-Molik, Marta Kowalska, Irena Nalepa
Behavioural pharmacology, 10.1097/FBP.0000000000000204
PMID:26588212 -
Erratum to: Neuroprotective Effect of the Endogenous Amine 1MeTIQ in an Animal Model of Parkinson's Disease.
Agnieszka Wasik, Irena Romańska, Jerzy Michaluk, Agnieszka Zelek-Molik, Irena Nalepa, Lucyna Antkiewicz-Michaluk
Neurotoxicity research,
PMID:27106849 -
Depressive-like immobility behavior and genotype × stress interactions in male mice of selected strains.
Piotr Chmielarz, Grzegorz Kreiner, Justyna Kuśmierczyk, Marta Kowalska, Adam Roman, Katarzyna Tota, Irena Nalepa
Stress (Amsterdam, Netherlands), 10.3109/10253890.2016.1150995
PMID:26941077 -
Neuroprotective Effect of the Endogenous Amine 1MeTIQ in an Animal Model of Parkinson's Disease.
Agnieszka Wąsik, Irena Romańska, Jerzy Michaluk, Agnieszka Zelek-Molik, Irena Nalepa, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-015-9556-6
PMID:26303030 -
Imipramine administration induces changes in the phosphorylation of FAK and PYK2 and modulates signaling pathways related to their activity.
Teresa Zalewska, Adam Bielawski, Luiza Stanaszek, Krzysztof Wieczerzak, Małgorzata Ziemka-Nałęcz, Irena Nalepa
Biochimica et biophysica acta, 10.1016/j.bbagen.2015.11.008 S0304-4165(15)00325-6
PMID:26620976 -
Selective ablation of glucocorticoid receptors in the noradrenergic system affects evening corticosterone levels in a sex-dependent manner.
Piotr Chmielarz, Grzegorz Kreiner, Irena Nalepa
Pharmacological reports : PR, 10.1016/j.pharep.2015.05.013 S1734-1140(15)00100-0
PMID:26481542
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Evaluation of the influence of progressive noradrenergic neurodegeneration on dopaminergic system functioning in context of presymptomatic phase of Parkinson's disease., Grzegorz Kreiner, PhD
OPUS13 2017/25/B/NZ7/02406
Principal Investigator: Dr Grzegorz Kreiner -
, Professor Irena Nalepa, PhD
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, Professor Irena Nalepa, PhD
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Evaluation of the role of transcription factor CREB in the mechanisms antidepressant treatment, Grzegorz Kreiner, PhD
OPUS7 2014/13/B/NZ7/02293
Principal Investigator: Dr Grzegorz Kreiner -
Pharmacological evaluation of possible neuroprotective strategies in novel genetic mouse models of progressive neurodegeneration, based on tissue specific inducible Cre/loxP system , Grzegorz Kreiner, PhD
OPUS2 2011/03/B/NZ7/05949
Principal Investigator: Dr Grzegorz Kreiner
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, Professor Irena Nalepa, PhD
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, Adam Roman, PhD
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Investigation of noradrenergic and glucocorticoid system interactions in GRDBHCre mice and their evaluation as a potential model of depression, Grzegorz Kreiner, PhD
POIG 01.01.02-12-004/09 DeMeTer (Depression – Mechanisms – Therapy).
Task 1.1 Subtask 1.1.2. Main topic: Modelling of depression – strategy of learning about its aetiology. Principal Investigator of task 1.2: Dr Grzegorz Kreiner
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, Professor Irena Nalepa, PhD
interests
techniques
- cDNA microarrays
- chronic mild stress
- colorometric evaluation of macrophage activity
- electroconvulsive therapy
- electrophoresis
- ELISA
- flow cytometry
- forced swim test
- genotyping
- HTRF
- immobilisation stress
- immune cells tissue cultures
- immunofluorescence
- immunohistochemistry
- in vitro transfection
- mammalian cells tissue cultures
- microinjections
- molecular cloning
- MTT test
- northern blot
- primary cultures
- protein fractioning
- protein microarrays
- radiologand binding
- Real Time PCR
- spectroscopy UV-VIS
- tail suspension test
- tissue cultures with stable expressing genes encoding selected proteins
- TLDA microarrays
- transgenic models based on conditioned/inducible recombinaze Cre/loxP
- Western Blot
keywords
- animal models
- antidepressants
- apoptosis
- bioinformatics
- cytokines
- depression
- drug addiction
- G-protein coupled receptors
- gene expression
- glia
- glutamate
- hippocampus
- imipramine
- immune system
- macrophages
- molecular biology
- mouse
- neurons
- neuroprotection
- noradrenaline
- prefrontal cortex
- psychopharmacology
- rat
- second messengers
- signaling proteins
- stress
- thalamus
- treatment-resistant depression
