Department of Neurochemistry

- Research of new endogenous substances with neuroprotective and antidepressant properties: endogenous tetrahydroisoquinoline amines (TIQ and 1MeTIQ) as potential safe drugs in clinic

Animal models of PD
inhibitor of VMAT
dopamine metabolism and release (in vivo as a target for neurotoxic and neuroprotective agents)
neurobiological mechanisms underlying depression in Parkinson's disease

behavioral and neurochemical correlates of craving and drug dependence (cocaine, morphine)
neuroprotective tetrahydroisoquinolines (TIQ, 1MeTIQ) as neuroprotective, antiaddictive and antidepressant agents
role of dopamine and its extraneuronal metabolite, 3-metoxytyramine (3-MT) in dopamine hyperactivity and drug addiction: behavioral and molecular studies
the neurotoxic effects of endogenous substances which may be responsible for Parkinson’s disease (salsolinol and 1BnTIQ)

- locomotor activity
- stereotypy
- catalepsy
- tail flick and hot plate tests
- Porsolt’s test
- instrumental treatments - electroconvulsive shock
- the implantation of chronic cannula into brain structures
- microinjections into the brain
- chemical lesions of the brain
- verification of brain lesions and microinjection sites
- in vitro and ex vivo radioligand binding assay the HPLC with ED analysis of biogenic amines and their metabolites concentrations in the brain structures:
dopamine (DA) and its metabolites (DOPAC, 3-MT, HVA)
noradrenaline (NA) and its metabolites (MOPEG, NM)
serotonin (5-HT) and its metabolite (5-HIAA)
excitatory amino acids (Glu, Asp)
assessment of monoamine metabolic rates
- in vivo microdialysis study and analysis of extracellular biogenic amines and excitatory amino acids in the brain structures of freely moving rat (HPLC Coulochem System with UV detector)
- assay of monoamine tissue uptake
- assay of MAO activity

The Department cooperates with:
Department of Psychiatry and Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA

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