Department of Pharmacology
The Department of Pharmacology includes:
Laboratory of Pharmacology and Brain Biostructure
Laboratory of Behavioral Pharmacology
Laboratory of Biochemical Pharmacology
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Early-life stress affects peripheral, blood-brain barrier, and brain responses to immune challenge in juvenile and adult rats.
Anna Solarz, Iwona Majcher-Maślanka, Joanna Kryst, Agnieszka Chocyk
Brain, behavior, and immunity, 10.1016/j.bbi.2022.11.005 S0889-1591(22)00434-2
PMID:36400335 -
Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents - systematic review and meta-analysis.
Joanna Kryst, Iwona Majcher-Maślanka, Agnieszka Chocyk
Pharmacological reports : PR, 10.1007/s43440-022-00420-w
PMID:36151445 -
Effect of Psilocybin and Ketamine on Brain Neurotransmitters, Glutamate Receptors, DNA and Rat Behavior.
Adam Wojtas, Agnieszka Bysiek, Agnieszka Wawrzczak-Bargiela, Zuzanna Szych, Iwona Majcher-Maślanka, Monika Herian, Marzena Maćkowiak, Krystyna Gołembiowska
International journal of molecular sciences, 6713 10.3390/ijms23126713
PMID:35743159 -
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Agata Kowalik, Mateusz Majerek, Krzysztof Mrowiec, Joanna Solich, Agata Faron-Górecka, Olga Woźnicka, Marta Dziedzicka-Wasylewska, Sylwia Łukasiewicz
Biomolecules, 749 10.3390/biom12060749
PMID:35740874 -
Pro-cognitive effect of acute imipramine administration correlates with direct interaction of BDNF with its receptor, Trkβ.
Agata Faron-Górecka, Maciej Kuśmider, Piotr Gruca, Paulina Pabian, Agata Korlatowicz, Joanna Solich, Magdalena Kolasa, Marta Dziedzicka-Wasylewska
Brain research, S0006-8993(22)00172-X 10.1016/j.brainres.2022.147948
PMID:35597327 -
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Micaela Tirri, Sabrine Bilel, Raffaella Arfè, Giorgia Corli, Beatrice Marchetti, Tatiana Bernardi, Federica Boccuto, Giovanni Serpelloni, Francesco Botrè, Fabio De-Giorgio, Krystyna Golembiowska, Matteo Marti
Frontiers in psychiatry, 10.3389/fpsyt.2022.875722
PMID:35530025 -
Neurotoxicological profile of the hallucinogenic compound 25I-NBOMe.
Monika Herian, Adam Wojtas, Marzena Maćkowiak, Agnieszka Wawrzczak-Bargiela, Anna Solarz, Agnieszka Bysiek, Katarzyna Madej, Krystyna Gołembiowska
Scientific reports, 10.1038/s41598-022-07069-8
PMID:35190675 -
Prenatal Exposure to Triclocarban Impairs ESR1 Signaling and Disrupts Epigenetic Status in Sex-Specific Ways as Well as Dysregulates the Expression of Neurogenesis- and Neurotransmitter-Related Genes in the Postnatal Mouse Brain.
Agnieszka Wnuk, Joanna Rzemieniec, Karolina Przepiórska, Bernadeta Angelika Pietrzak, Marzena Maćkowiak, Małgorzata Kajta
International journal of molecular sciences, 13121 10.3390/ijms222313121
PMID:34884933 -
Posttreatment Strategy Against Hypoxia and Ischemia Based on Selective Targeting of Nonnuclear Estrogen Receptors with PaPE-1.
A Wnuk, K Przepiórska, B A Pietrzak, M Kajta
Neurotoxicity research, 10.1007/s12640-021-00441-y
PMID:34797527 -
Identification of Molecular Markers of Clozapine Action in Ketamine-Induced Cognitive Impairment: A GPCR Signaling PathwayFinder Study.
Agata Korlatowicz, Maciej Kuśmider, Marta Szlachta, Paulina Pabian, Joanna Solich, Marta Dziedzicka-Wasylewska, Agata Faron-Górecka
International journal of molecular sciences, 12203 10.3390/ijms222212203
PMID:34830086 -
Neurotoxicity of MDMA: Main effects and mechanisms.
Giulia Costa, Krystyna Gołembiowska
Experimental neurology, S0014-4886(21)00302-2 10.1016/j.expneurol.2021.113894
PMID:34655576 -
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Magdalena Kusek, Marcin Siwiec, Joanna Ewa Sowa, Bartosz Bobula, Wiktor Bilecki, Izabela Ciurej, Maria Kaczmarczyk, Tomasz Kowalczyk, Marzena Maćkowiak, Grzegorz Hess, Krzysztof Tokarski
Neuropharmacology, S0028-3908(21)00334-8 10.1016/j.neuropharm.2021.108779
PMID:34481835 -
MicroRNA Let-7e in the Mouse Prefrontal Cortex Differentiates Restraint-Stress-Resilient Genotypes from Susceptible Genotype.
Joanna Solich, Magdalena Kolasa, Agata Faron-Górecka, Jacek Hajto, Marcin Piechota, Marta Dziedzicka-Wasylewska
International journal of molecular sciences, 9439 10.3390/ijms22179439
PMID:34502349 -
Effects of early-life stress and sex on blood-brain barrier permeability and integrity in juvenile and adult rats.
Anna Solarz, Iwona Majcher-Maślanka, Agnieszka Chocyk
Developmental neurobiology, 10.1002/dneu.22846
PMID:34320279 -
Inhibition of BET Proteins during Adolescence Affects Prefrontal Cortical Development: Relevance to Schizophrenia.
Wiktor Bilecki, Agnieszka Wawrzczak-Bargieła, Iwona Majcher-Maślanka, Magdalena Chmelova, Marzena Maćkowiak
International journal of molecular sciences, 8710 10.3390/ijms22168710
PMID:34445411
- GOŁEMBIOWSKA K.: Pharmacology and Neurotoxicity of 5-MeO-DIPT. In: Kostrzewa R.M. (eds) Handbook of Neurotoxicity. Springer, Cham, 2021, 1-12.
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1. Faron-Górecka A, Szafran-Pilch K. (2016) Prolactin and Somatostatin Responses to Antidepressant Therapy. In: López-Muñoz F., Srinivasan V., de Berardis D., Álamo C., Kato T. (eds) Melatonin, Neuroprotective Agents and Antidepressant Therapy. Springer, N
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Understanding GPCR dimerization. Methods in Cell Biology, Elsevier https://doi.org/10.1016/bs.mcb.2018.08.005
Faron-Górecka A, Kuśmider M, Solich J, Górecki A, Dziedzicka-Wasylewska M. (2020) Genetic variants in dopamine receptors influence on heterodimerization in the context of antipsychotic drug action. Progress in Molecular Biology and Translational Science, Elsevier https://doi.org/10.1016/bs.pmbts.2019.11.008
Faron-Górecka A, Szlachta M, Kolasa M, Solich J, Górecki A, Kuśmider M, Żurawek D, Dziedzicka-Wasylewska M. (2019) Understanding GPCR dimerization. Methods in Cell Biology, Elsevier https://doi.org/10.1016/bs.mcb.2018.08.005
Faron-Górecka A, Szafran-Pilch K. (2016) Prolactin and Somatostatin Responses to Antidepressant Therapy. In: López-Muñoz F., Srinivasan V., de Berardis D., Álamo C., Kato T. (eds) Melatonin, Neuroprotective Agents and Antidepressant Therapy. Springer, New Delhi
Zurawek D., Faron-Górecka A, Kuśmider M, Solich J, Kolasa M, Szafran-Pilch K, Kmiotek K, Gruca P, Papp M, Dziedzicka-Wasylewska M. (2015) Dopamine D1 and D2 Receptors in Chronic Mild Stress: Analysis of Dynamic Receptor Changes in an Animal Model of Depression Using In Situ Hybridization and Autoradiography. In: Tiberi M. (eds) Dopamine Receptor Technologies. Neuromethods, vol 96. Humana Press, New York, NY
Łukasiewicz S, Faron-Górecka A, Dziedzicka-Wasylewska M. (2013) A Biophysical Approach for the Study of Dopamine Receptor Oligomerization. In: Kabbani N. (eds) Dopamine. Methods in Molecular Biology (Methods and Protocols), vol 964. Humana Press, Totowa, NJ
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Effects of Synthetic Cathinones on Brain Neurotransmitters.
GOŁEMBIOWSKA K., KAMIŃSKA K. Effects of Synthetic Cathinones on Brain Neurotransmitters. In: Zawilska J. B. (ed.) Synthetic Cathinones. Current Topics in Neurotoxicity 12. Springer International Publishing AG, Cham, 2018, p. 117-124.
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Tirri Micaela, Bilel Sabrine, Arfè Raffaella, Corli Giorgia, Marchetti Beatrice, Bernardi Tatiana, Boccuto Federica, Serpelloni Giovanni, Botrè Francesco, De-Giorgio Fabio, Golembiowska Krystyna, Marti Mateo. Effect of –NBOMe Compounds on sensorimotor, motor, and prepulse inhibition responses in mice in comparison with the 2C analogs and Lysergic Acid Diethylamide: from preclinical evidence to forensic implication in driving under the influence of drugs. Front. Psychiatry, April 2022, 13, 875722. https://doi.org/10.3389/fpsyt.2022.875722
- GOŁEMBIOWSKA K., KAMIŃSKA K. Effects of Synthetic Cathinones on Brain Neurotransmitters. In: Zawilska J. B. (ed.) Synthetic Cathinones. Current Topics in Neurotoxicity 12. Springer International Publishing AG, Cham, 2018, p. 117-124.
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Selective PPARγ modulation by amorfrutin B as a novel therapeutic approach to chemotherapy-induced damage to mammalian brain cells, Bernadeta Pietrzak-Wawrzyńska, MSc
NCN PRELUDIUM 22 Grant; 2023/49/N/NZ7/03640 Principal Investigator of the project: Bernadeta A. Pietrzak-Wawrzyńska, MSc, The Scientific Supervisor of the project: Professor Małgorzata Kajta -
Neurochemical basis of antidepressive properties of psychedelics in rodent model of depression OPUS 19 2020/37/B/NZ7/03753, Professor Krystyna Gołembiowska, PhD
Neurochemical basis of antidepressive properties of psychedelics in rodent model of depression -
Pharmacological and optogenetic investigation of the mechanism of action of Deep Brain Stimulation of the ventromedial prefrontal cortex in an animal model of treatmentresistant depression, Professor Mariusz Papp, PhD
NCN grant no: 2017/25/B/NZ7/02710 -
The role of endoplasmic reticulum stress in the pathomechanisms of early-life stressinduced dysfunction of the prefronatal cortex and in the mechanisms of action of fluoxetine in children and adolescents, Agnieszka Chocyk, PhD
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Impact of early-life stress on maturation, permeability of blood brain-barrier and neuroinflammatory processes activation during ontogenetic development , Anna Solarz-Andrzejewska, PhD
Preludium 12 2016/23/N/NZ4/01148 - kierownik -
Pharmacological properties and neurotoxicity of novel NBOMe derivatives, Professor Krystyna Gołembiowska, PhD
OPUS11 2016/21/B/NZ7/01131
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Investigation of the effects and mechanisms of action of Deep Brain Stimulation in two animal models of treatment-resistant depression., Professor Mariusz Papp, PhD
NCN grant no: 2015/17/B/NZ7/02979 -
, Agnieszka Chocyk, PhD
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NCN OPUS 8 Molecular mechanism of the unique action of clozapine in the context of heterodimerization of receptors associated with G proteins., Agata Faron - Górecka, PhD
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The effect of imipramine and risperidone on regulation of the chronic mild stressinduced anhedonia and memory impairment by the limbic D1, D2 and D3 receptors in rats, Professor Mariusz Papp, PhD
NCN grant no: 2013/09/B/NZ7/04098 -
Endogenous markers of the effectiveness of depression therapy in the model of chronic mild stress (CMS). , Agata Faron - Górecka, PhD
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, Agnieszka Chocyk, PhD
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, Professor Krystyna Gołembiowska, PhD
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, Professor Krystyna Gołembiowska, PhD
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, Professor Krystyna Gołembiowska, PhD
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Scientific Award of the Faculty of Medical Sciences of the Polish Academy of Sciences: prof dr hab. Marta Dziedzicka-Wasylewska, dr hab. Agata Faron-Górecka, dr Joanna Solich, Agata Faron - Górecka, PhD
Thursday, 17 November 2022 -
FNP scholarship for young scientists (START Program), Agata Faron - Górecka, PhD
Saturday, 26 April 2008 -
FNP scholarship for young scientists (START Program), Agata Faron - Górecka, PhD
Saturday, 21 April 2007 -
ECNP Travel Award - ECNP Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nicea, France, Agata Faron - Górecka, PhD
Thursday, 9 March 2006 -
ECNP Travel Award - ECNP Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nicea, France, Agata Faron - Górecka, PhD
Saturday, 8 March 0200 -
, Professor Marta Dziedzicka - Wasylewska, PhD
Monday, 30 November -0001
interests
techniques
- analysis and interpretation of big genomic data-sets
- chronic psychosocial stress
- conditioned place preference
- drug self administration
- eleveted zero test
- fear conditioning
- genotyping
- HPLC EC
- HPLC UV
- in vitro transfection
- prepulse inhibition
- resident intruder paradigm
- stereotypy
- TLDA microarrays
- whole cell recordings
keywords
- 3,3’-diindolylmethane
- 6-OHDA
- adenosine
- adenosine receptors
- amphetamine
- animal models
- antidepressants
- antipsychotics
- anxiolytics
- apoptosis
- aryl hydrocarbon receptor – AhR
- asphyxia
- autophagy
- axonal transport
- Bazedoxifene
- behavioural analysis
- Benzophenone-3
- biomarker
- chronic schizophrenia
- citalopram
- cognitive flexibility
- cognitive functions
- depression
- desipramine
- drug addiction
- epigenetics
- escitalopram
- estrogen receptors
- estrogen receptors – ERs
- excitotoxicity
- fluorescent microscopy
- frontal cortex
- G-protein coupled receptors
- GABA
- gene expression
- gene expression profiling
- glutamate
- glutamatergic receptors
- hippocampus
- hypoxia
- hypoxia
- imipramine
- immobilization stress
- ischemia
- judgment bias
- learning
- MDMA
- memory
- metabotropic glutamate receptors
- miRNA