Department of Pharmacology
The Department of Pharmacology includes:
Laboratory of Pharmacology and Brain Biostructure
Laboratory of Behavioral Pharmacology
Laboratory of Biochemical Pharmacology
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Early-life stress affects peripheral, blood-brain barrier, and brain responses to immune challenge in juvenile and adult rats.
Anna Solarz, Iwona Majcher-Maślanka, Joanna Kryst, Agnieszka Chocyk
Brain, behavior, and immunity, 10.1016/j.bbi.2022.11.005 S0889-1591(22)00434-2
PMID:36400335 -
Trait sensitivity to negative feedback determines the effects of chronic stress and chronic mirtazapine treatment on anxiety and stress-coping strategies in rats.
Paulina Surowka, Karolina Noworyta, Agata Cieslik, Rafal Rygula
Psychopharmacology, 10.1007/s00213-022-06273-8
PMID:36352265 -
Amorfrutin B Protects Mouse Brain Neurons from Hypoxia/Ischemia by Inhibiting Apoptosis and Autophagy Processes Through Gene Methylation- and miRNA-Dependent Regulation.
Karolina Przepiórska, Agnieszka Wnuk, Cordian Beyer, Małgorzata Kajta
Molecular neurobiology, 10.1007/s12035-022-03087-9
PMID:36324052 -
Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents - systematic review and meta-analysis.
Joanna Kryst, Iwona Majcher-Maślanka, Agnieszka Chocyk
Pharmacological reports : PR, 10.1007/s43440-022-00420-w
PMID:36151445 -
Trait sensitivity to negative feedback determines the intensity of compulsive alcohol seeking and taking in male rats.
Agata Cieslik, Karolina Noworyta, Rafal Rygula
Journal of psychiatry & neuroscience : JPN, 10.1503/jpn.210220
PMID:35820699 -
Effect of Psilocybin and Ketamine on Brain Neurotransmitters, Glutamate Receptors, DNA and Rat Behavior.
Adam Wojtas, Agnieszka Bysiek, Agnieszka Wawrzczak-Bargiela, Zuzanna Szych, Iwona Majcher-Maślanka, Monika Herian, Marzena Maćkowiak, Krystyna Gołembiowska
International journal of molecular sciences, 6713 10.3390/ijms23126713
PMID:35743159 -
Cognitive Processes and Personality Traits Underlying Four Phenotypes of Susceptibility to (Mis)Information.
Michal Piksa, Karolina Noworyta, Jan Piasecki, Pawel Gwiazdzinski, Aleksander B Gundersen, Jonas Kunst, Rafal Rygula
Frontiers in psychiatry, 10.3389/fpsyt.2022.912397
PMID:35782415 -
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Agata Kowalik, Mateusz Majerek, Krzysztof Mrowiec, Joanna Solich, Agata Faron-Górecka, Olga Woźnicka, Marta Dziedzicka-Wasylewska, Sylwia Łukasiewicz
Biomolecules, 749 10.3390/biom12060749
PMID:35740874 -
Pro-cognitive effect of acute imipramine administration correlates with direct interaction of BDNF with its receptor, Trkβ.
Agata Faron-Górecka, Maciej Kuśmider, Piotr Gruca, Paulina Pabian, Agata Korlatowicz, Joanna Solich, Magdalena Kolasa, Marta Dziedzicka-Wasylewska
Brain research, S0006-8993(22)00172-X 10.1016/j.brainres.2022.147948
PMID:35597327 -
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Micaela Tirri, Sabrine Bilel, Raffaella Arfè, Giorgia Corli, Beatrice Marchetti, Tatiana Bernardi, Federica Boccuto, Giovanni Serpelloni, Francesco Botrè, Fabio De-Giorgio, Krystyna Golembiowska, Matteo Marti
Frontiers in psychiatry, 10.3389/fpsyt.2022.875722
PMID:35530025 -
Neurotoxicological profile of the hallucinogenic compound 25I-NBOMe.
Monika Herian, Adam Wojtas, Marzena Maćkowiak, Agnieszka Wawrzczak-Bargiela, Anna Solarz, Agnieszka Bysiek, Katarzyna Madej, Krystyna Gołembiowska
Scientific reports, 10.1038/s41598-022-07069-8
PMID:35190675 -
Prenatal Exposure to Triclocarban Impairs ESR1 Signaling and Disrupts Epigenetic Status in Sex-Specific Ways as Well as Dysregulates the Expression of Neurogenesis- and Neurotransmitter-Related Genes in the Postnatal Mouse Brain.
Agnieszka Wnuk, Joanna Rzemieniec, Karolina Przepiórska, Bernadeta Angelika Pietrzak, Marzena Maćkowiak, Małgorzata Kajta
International journal of molecular sciences, 13121 10.3390/ijms222313121
PMID:34884933 -
Posttreatment Strategy Against Hypoxia and Ischemia Based on Selective Targeting of Nonnuclear Estrogen Receptors with PaPE-1.
A Wnuk, K Przepiórska, B A Pietrzak, M Kajta
Neurotoxicity research, 10.1007/s12640-021-00441-y
PMID:34797527 -
Neuromolecular Underpinnings of Negative Cognitive Bias in Depression.
Karolina Noworyta, Agata Cieslik, Rafal Rygula
Cells, 3157 10.3390/cells10113157
PMID:34831380 -
Identification of Molecular Markers of Clozapine Action in Ketamine-Induced Cognitive Impairment: A GPCR Signaling PathwayFinder Study.
Agata Korlatowicz, Maciej Kuśmider, Marta Szlachta, Paulina Pabian, Joanna Solich, Marta Dziedzicka-Wasylewska, Agata Faron-Górecka
International journal of molecular sciences, 12203 10.3390/ijms222212203
PMID:34830086
- A popular-science article "From birth to old age - amorfrutin B in neuroprotection" Karolina Przepiórska
- GOŁEMBIOWSKA K.: Pharmacology and Neurotoxicity of 5-MeO-DIPT. In: Kostrzewa R.M. (eds) Handbook of Neurotoxicity. Springer, Cham, 2021, 1-12.
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- Popular science article "Sunscreen cream - friend or foe?" Agnieszka Wnuk
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In search of new therapeutic strategies for the treatment of hypoxia-ischemia-induced brain damages. An article in Polish.
NAUKA, 2016, 3:55-73. Kajta M, Rzemieniec J, Rużyłło W.
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Neurobiology of optimism (article in polish)
The article was published in journal "Wszechświat" and is based on a talk given during the 2014 Brain Awarness Week in Krakow.
http://www.ptpk.org/tydzien_mozgu/tydzien_mozgu_2014.html#art_5
- How hormonally active environmental contaminants affect the brain? An article in Polish. Wszechświat, 2012, 113:10-13. Kajta M.
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Molecular mechanisms of estrogen action in the central nervous system. An article in Polish.
Chapter in the script: Cellular signaling pathways. Edited by I. Nalepa. XXI Zimowa Szkoła Instytutu Farmakologii PAN. Mogilany, 2004,
61-69. Kajta M.
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Neuronal cell cultures. An article in Polish.
Chapter XVII in the book: Cell and Tissue Cultures. Edited by S. Stokłosowa. PWN, Warszawa, 2004, 277-290. Kajta M.
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1. Faron-Górecka A, Szafran-Pilch K. (2016) Prolactin and Somatostatin Responses to Antidepressant Therapy. In: López-Muñoz F., Srinivasan V., de Berardis D., Álamo C., Kato T. (eds) Melatonin, Neuroprotective Agents and Antidepressant Therapy. Springer, N
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Understanding GPCR dimerization. Methods in Cell Biology, Elsevier https://doi.org/10.1016/bs.mcb.2018.08.005
Faron-Górecka A, Kuśmider M, Solich J, Górecki A, Dziedzicka-Wasylewska M. (2020) Genetic variants in dopamine receptors influence on heterodimerization in the context of antipsychotic drug action. Progress in Molecular Biology and Translational Science, Elsevier https://doi.org/10.1016/bs.pmbts.2019.11.008
Faron-Górecka A, Szlachta M, Kolasa M, Solich J, Górecki A, Kuśmider M, Żurawek D, Dziedzicka-Wasylewska M. (2019) Understanding GPCR dimerization. Methods in Cell Biology, Elsevier https://doi.org/10.1016/bs.mcb.2018.08.005
Faron-Górecka A, Szafran-Pilch K. (2016) Prolactin and Somatostatin Responses to Antidepressant Therapy. In: López-Muñoz F., Srinivasan V., de Berardis D., Álamo C., Kato T. (eds) Melatonin, Neuroprotective Agents and Antidepressant Therapy. Springer, New Delhi
Zurawek D., Faron-Górecka A, Kuśmider M, Solich J, Kolasa M, Szafran-Pilch K, Kmiotek K, Gruca P, Papp M, Dziedzicka-Wasylewska M. (2015) Dopamine D1 and D2 Receptors in Chronic Mild Stress: Analysis of Dynamic Receptor Changes in an Animal Model of Depression Using In Situ Hybridization and Autoradiography. In: Tiberi M. (eds) Dopamine Receptor Technologies. Neuromethods, vol 96. Humana Press, New York, NY
Łukasiewicz S, Faron-Górecka A, Dziedzicka-Wasylewska M. (2013) A Biophysical Approach for the Study of Dopamine Receptor Oligomerization. In: Kabbani N. (eds) Dopamine. Methods in Molecular Biology (Methods and Protocols), vol 964. Humana Press, Totowa, NJ
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Effects of Synthetic Cathinones on Brain Neurotransmitters.
GOŁEMBIOWSKA K., KAMIŃSKA K. Effects of Synthetic Cathinones on Brain Neurotransmitters. In: Zawilska J. B. (ed.) Synthetic Cathinones. Current Topics in Neurotoxicity 12. Springer International Publishing AG, Cham, 2018, p. 117-124.
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Tirri Micaela, Bilel Sabrine, Arfè Raffaella, Corli Giorgia, Marchetti Beatrice, Bernardi Tatiana, Boccuto Federica, Serpelloni Giovanni, Botrè Francesco, De-Giorgio Fabio, Golembiowska Krystyna, Marti Mateo. Effect of –NBOMe Compounds on sensorimotor, motor, and prepulse inhibition responses in mice in comparison with the 2C analogs and Lysergic Acid Diethylamide: from preclinical evidence to forensic implication in driving under the influence of drugs. Front. Psychiatry, April 2022, 13, 875722. https://doi.org/10.3389/fpsyt.2022.875722
- GOŁEMBIOWSKA K., KAMIŃSKA K. Effects of Synthetic Cathinones on Brain Neurotransmitters. In: Zawilska J. B. (ed.) Synthetic Cathinones. Current Topics in Neurotoxicity 12. Springer International Publishing AG, Cham, 2018, p. 117-124.
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Selective PPARγ modulation by amorfrutin B as a novel therapeutic approach to chemotherapy-induced damage to mammalian brain cells, Bernadeta Pietrzak-Wawrzyńska, MSc
NCN PRELUDIUM Grant; 2023/49/N/NZ7/03640 Principal Investigator of the project: Bernadeta A. Pietrzak-Wawrzyńska, MSc, The Scientific Supervisor of the project: Professor Małgorzata Kajta -
Selective modulation of PPARγ signaling as a new therapeutic strategy for Alzheimer’s disease, Karolina Przepiórska-Drońska, MSc
NCN PRELUDIUM Grant; 2022/45/N/NZ7/01418; 2023-2026. Ongoing.
Principal Investigator of the grant: Karolina PrzepiórskaThe scientific supervisor of the grant: Professor Małgorzata Kajta
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Translational and interdisciplinary investigation of phenotypes of reinforcement sensitivity as predictors of the response to antidepressant treatment, Professor Rafał Ryguła, PhD
Why do antidepressant drugs fail to work in some people suffering from depression, while for others they quickly bring relief of their symptoms? Are the positive outcomes of antidepressant treatment associated with sensitivity to reward and punishment? And if so, could screening of this sensitivity facilitate finding of the right treatment? Although the relationship between reinforcement sensitivity, affective disorders, and effectivity of pharmacological treatment has been widely postulated and brought together through influential theoretical narratives, until now, there has been no systematic study aimed at investigating these interactions. To address this need, in the present project, we will employ a novel animal model linking various levels of sensitivity to reward and punishment with a putative reactivity to antidepressant treatment. We will also compare the obtained results from animals with the data from humans taking antidepressant medications, using the pioneering online techniques and fully translational behavioural tests. Finally, we will verify, compare, and extend the results from animals and humans using computational modelling of behaviour. Based on the proposed experiments we will be able to conduct complex and multilevel verification of the hypothesis that trait sensitivity to reward and punishment (phenotype of reinforcement sensitivity) can determine the interindividual differences in the effectiveness of antidepressant treatment. Obtained results will be used to understand the phenomena of drug resistance and low effectiveness in antidepressant therapy.
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New post-treatment strategy against stroke and perinatal asphyxia – a novel approach based on a selective activation of membrane estrogen receptors mERα and mERβ, Agnieszka Wnuk, , Agnieszka Wnuk, PhD
NCN SONATA Grant; 2021/43/D/NZ7/00633; 2022-2025. Ongoing.Principal Investigator of the grant: Agnieszka Wnuk, PhD -
Selective activation of non-nuclear Estrogen Receptor signaling with PaPE-1 as a novel therapeutic approach for sporadic Alzheimer’s Disease, Professor Małgorzata Kajta, PhD
NCN OPUS Grant; 2020/39/B/NZ7/00974; 2021-2024. Ongoing.
Principal Investigator of the grant: Małgorzata Kajta -
Neurochemical basis of antidepressive properties of psychedelics in rodent model of depression OPUS 19 2020/37/B/NZ7/03753, Professor Krystyna Gołembiowska, PhD
Neurochemical basis of antidepressive properties of psychedelics in rodent model of depression -
#Webimmunization. How can online social networks create collective resilience against misinformation?”, Professor Rafał Ryguła, PhD
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The role of cognitive bias in individual vulnerability to to the transition from controlled use to uncontrolled abuse of alcohol in an animal model., Professor Rafał Ryguła, PhD
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Searching for effective strategies to protect neuronal cells against hypoxia and ischemia: Identification of neuroprotective mechanisms of the new ligands of AhR and PPARg in experimental models of stroke, Professor Małgorzata Kajta, PhD
NCN OPUS Grant; 2018/31/B/NZ7/01815; 2019-2022. Ongoing.Principal Investigator of the grant: Małgorzata Kajta
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Neuroscience boat, Professor Rafał Ryguła, PhD
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, Professor Rafał Ryguła, PhD
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Pharmacological and optogenetic investigation of the mechanism of action of Deep Brain Stimulation of the ventromedial prefrontal cortex in an animal model of treatmentresistant depression, Professor Mariusz Papp, PhD
NCN grant no: 2017/25/B/NZ7/02710 -
The role of endoplasmic reticulum stress in the pathomechanisms of early-life stressinduced dysfunction of the prefronatal cortex and in the mechanisms of action of fluoxetine in children and adolescents, Agnieszka Chocyk, PhD
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Sensitivity to negative feedback as a cognitive biomarker of depression in an animal model, Professor Rafał Ryguła, PhD
Carried out in years 2017 - 2020. Received from Polish National Science Centre as a part of OPUS 12 program. P.I.: Rafal Rygula -
Impact of early-life stress on maturation, permeability of blood brain-barrier and neuroinflammatory processes activation during ontogenetic development , Anna Solarz-Andrzejewska, PhD
Preludium 12 2016/23/N/NZ4/01148 - kierownik
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Scientific Award of the Faculty of Medical Sciences of the Polish Academy of Sciences: prof dr hab. Marta Dziedzicka-Wasylewska, dr hab. Agata Faron-Górecka, dr Joanna Solich, Agata Faron - Górecka, PhD
Thursday, 17 November 2022 -
The first place in the competition for a popular-science article "From birth to old age - amorfrutin B in neuroprotection" - the Organizer: board of Directors of the Maj Institute of Pharmacology of the Polish Academy of Sciences., Karolina Przepiórska-Drońska, MSc
Thursday, 30 September 2021 -
Team Award of the V Faculty of Medical Sciences of the Polish Academy of Sciences for a series of publications., Agnieszka Wnuk, PhD
Thursday, 22 November 2018 -
A Team Award of the V Faculty of Medical Sciences of the Polish Academy of Sciences for a series of publications. , Professor Małgorzata Kajta, PhD
Thursday, 22 November 2018 -
Stipends START 2018 granted by The Foundation for Polish Science (FNP) stipends for the young scientists, Agnieszka Wnuk, PhD
Saturday, 26 May 2018 -
The second place in the competition for a popular-science article "Sunscreen cream - friend or foe?"- the Organizer: Directorate of the IF PAS in Krakow , Agnieszka Wnuk, PhD
Wednesday, 15 November 2017 -
Rafal Rygula: Prime Minister's award for habilitation, Professor Rafał Ryguła, PhD
Thursday, 24 November 2016 -
FNP scholarship for young scientists (START Program), Agata Faron - Górecka, PhD
Saturday, 26 April 2008 -
FNP scholarship for young scientists (START Program), Agata Faron - Górecka, PhD
Saturday, 21 April 2007 -
ECNP Travel Award - ECNP Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nicea, France, Agata Faron - Górecka, PhD
Thursday, 9 March 2006 -
J. J. Supniewski Foundation award for scientific achievements., Professor Małgorzata Kajta, PhD
Wednesday, 25 February 2004 -
ECNP Travel Award - ECNP Workshop on Neuropsychopharmacology for Young Scientists in Europe, Nicea, France, Agata Faron - Górecka, PhD
Saturday, 8 March 0200 -
, Professor Marta Dziedzicka - Wasylewska, PhD
Monday, 30 November -0001
interests
techniques
- ambiguous-cue interpretation test
- analysis and interpretation of big genomic data-sets
- analysis of ultrasonic vocalisations
- behavioral sensitisation
- cDNA microarrays
- chronic psychosocial stress
- conditioned place preference
- drug self administration
- eleveted zero test
- fear conditioning
- genotyping
- HPLC EC
- HPLC UV
- in vitro transfection
- prepulse inhibition
- probabilistic reversal learning
- protein microarrays
- rat Slot Machine Task
- resident intruder paradigm
- reversal learning
- stereotypy
- TLDA microarrays
- voluntary alcohol drinking
- whole cell recordings
keywords
- 3,3’-diindolylmethane
- 5,7-DHT
- 6-OHDA
- adenosine
- adenosine receptors
- ADHD
- alcohol
- Alzheimer disease
- amphetamine
- amyloid
- animal models
- antidepressants
- antipsychotics
- anxiolytics
- apoptosis
- aryl hydrocarbon receptor – AhR
- asphyxia
- autophagy
- axonal transport
- Bazedoxifene
- behavioural analysis
- Benzophenone-3
- biomarker
- chronic schizophrenia
- citalopram
- cognitive flexibility
- cognitive functions
- cognitive neuroscience
- confocal microscopy
- Daidzein
- DDE
- DDT
- depression
- desipramine
- DNA methylation
- drug addiction
- epigenetics
- escitalopram
- estrogen receptors
- estrogen receptors – ERs
- excitotoxicity
- feedback sensitivity
- fluorescent microscopy
- frontal cortex
- G-protein coupled receptors
- GABA
- gene expression
- gene expression profiling
- genetics
- Genistein