Laboratory of Immunoendocrinology
The Laboratory of Immunoendocrinology is a part of the Department of Experimental Neuroendocrinology.
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Behavioral and neurochemical interactions of the tricyclic antidepressant drug desipramine with L-DOPA in 6-OHDA-lesioned rats. Implications for motor and psychiatric functions in Parkinson's disease.
Kinga Kamińska, Tomasz Lenda, Jolanta Konieczny, Elżbieta Lorenc-Koci
Psychopharmacology, 10.1007/s00213-022-06238-x
PMID:36178508 -
Mechanotransductive receptor Piezo1 as a promising target in the treatment of neurological diseases.
Natalia Bryniarska-Kubiak, Andrzej Kubiak, Agnieszka Basta-Kaim
Current neuropharmacology, 10.2174/1570159X20666220927103454
PMID:36173070 -
Introduction to the Special Section on
Katarzyna Głombik, Katarzyna Kuter-Nowak
Pharmacological reports : PR, 10.1007/s43440-022-00421-9
PMID:36149597 -
The Formyl Peptide Receptor 2 as a Target For Promotion of Resolution of Inflammation.
Ewa Trojan, Monika Leśkiewicz, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
Current neuropharmacology, 10.2174/1570159X20666220913155248
PMID:36100993 -
Quetiapine Ameliorates MIA-Induced Impairment of Sensorimotor Gating: Focus on Neuron-Microglia Communication and the Inflammatory Response in the Frontal Cortex of Adult Offspring of Wistar Rats.
Katarzyna Chamera, Katarzyna Curzytek, Kinga Kamińska, Ewa Trojan, Agnieszka Basta-Kaim
Cells, 2788 10.3390/cells11182788
PMID:36139363 -
Changes in regulators of lipid metabolism in the brain: a study of animal models of depression and hypothyroidism.
Katarzyna Głombik, Jan Detka, Magdalena Kukla-Bartoszek, Alicja Maciejska, Bogusława Budziszewska
Pharmacological reports : PR, 10.1007/s43440-022-00395-8
PMID:35951260 -
The Immune Profile of Major Dysmood Disorder: Proof of Concept and Mechanism Using the Precision Nomothetic Psychiatry Approach.
Michael Maes, Muanpetch Rachayon, Ketsupar Jirakran, Pimpayao Sodsai, Siriwan Klinchanhom, Piotr Gałecki, Atapol Sughondhabirom, Agnieszka Basta-Kaim
Cells, 1183 10.3390/cells11071183
PMID:35406747 -
Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders.
Margherita Mastromarino, Maria Favia, Igor A Schepetkin, Lylia N Kirpotina, Ewa Trojan, Mauro Niso, Antonio Carrieri, Monika Leśkiewicz, Magdalena Regulska, Massimiliano Darida, Francesco Rossignolo, Stefano Fontana, Mark T Quinn, Agnieszka Basta-Kaim, Marcello Leopoldo, Enza Lacivita
Journal of medicinal chemistry, 10.1021/acs.jmedchem.1c02203
PMID:35257581 -
N-Acetylcysteine and Aripiprazole Improve Social Behavior and Cognition and Modulate Brain BDNF Levels in a Rat Model of Schizophrenia.
Zofia Rogóż, Kinga Kamińska, Marta Anna Lech, Elżbieta Lorenc-Koci
International journal of molecular sciences, 2125 10.3390/ijms23042125
PMID:35216241 -
The emerging role for the double-edged impact of arachidonic acidderived eicosanoids in the neuroinflammatory background of depression.
Magdalena Regulska, Magdalena Szuster-Głuszczak, Ewa Trojan, Monika Leśkiewicz, Agnieszka Basta-Kaim
Current neuropharmacology, 10.2174/1570159X18666200807144530
PMID:32851950 -
Hormonal Regulation of Oxidative Phosphorylation in the Brain in Health and Disease.
Katarzyna Głombik, Jan Detka, Bogusława Budziszewska
Cells, 2937 10.3390/cells10112937
PMID:34831160 -
Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways.
Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Magdalena Regulska, Natalia Bryniarska, Katarzyna Curzytek, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
Cells, 2373 10.3390/cells10092373
PMID:34572022 -
The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Improves Ex Vivo and In Vivo Amyloid Beta (1-42)-Induced Neuroinflammation in Mouse Models of Alzheimer's Disease.
Ewa Trojan, Kinga Tylek, Nicole Schröder, Iris Kahl, Lars-Ove Brandenburg, Margherita Mastromarino, Marcello Leopoldo, Agnieszka Basta-Kaim, Enza Lacivita
Molecular neurobiology, 10.1007/s12035-021-02543-2
PMID:34468933 -
Impact of repeated co-treatment with escitalopram and aripiprazole on the schizophrenia-like behaviors and BDNF mRNA expression in the adult Sprague-Dawley rats exposed to glutathione deficit during early postnatal development of the brain.
Marta A Lech, Kinga Kamińska, Monika Leśkiewicz, Elżbieta Lorenc-Koci, Zofia Rogóż
Pharmacological reports : PR, 10.1007/s43440-021-00318-z
PMID:34398437 -
The emerging role of mechanical and topographical factors in the development and treatment of nervous system disorders: dark and light sides of the force.
Natalia Bryniarska-Kubiak, Andrzej Kubiak, Małgorzata Lekka, Agnieszka Basta-Kaim
Pharmacological reports : PR, 10.1007/s43440-021-00315-2
PMID:34390472
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Application of dental pulp stem cells in neural tissue regeneration
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OPUS 22. The role of the immune checkpoints in the pathomechanism of depressive disorders., Professor Marta Kubera, PhD
Grant NCN OPUS 22, consortium with the Jagiellonian University; 2022.10.10.-2025.10.09
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OPUS 22. New approach to the treatment of Alzheimer's disease targeting resolution of inflammation and modulation of biomechanical properties of microglia by FPR2 hybrid agonists., Professor Agnieszka Basta - Kaim, PhD
Grant NCN OPUS 22, 2021/43/B/NZ4/01133
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GRIEG 1. Theranostic nanocarriers for drug delivery in central nervous system disorders., Professor Władysław Lasoń, PhD
Grant GRIEG 1, 2019/34/H/ST5/00578; 2021.12.13-2024.04.12 -
CANALETTO 2021. Promoting resolution of inflammation as an innovate therapeutic strategy for central nervous system disorders characterized by neuroinflammation., Professor Agnieszka Basta - Kaim, PhD
Research project between Poland and Italy CANALETTO 2021 PPN/BIT/2021/1/00009 Maj Institute of Pharmacology Polish Academy of Sciences and Università di Bari -
, Katarzyna Głombik, PhD
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OPUS 20. New generation teranostatic nanocarriers for detection, diagnosis and neuroprotective treatment of ischemic stroke brain damage., Professor Władysław Lasoń, PhD
Grant NCN OPUS 20, 2020/39/B/NZ7/01913; 2021.07.16-2025.07.15
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PRELUDIUM 18: Evaluation of molecular mechanisms of neuroprotective action of dental pulp stromal cells in an ex vivo organotypic model of ischemia, Natalia Bryniarska-Kubiak, PhD
Principal investigator: Natalia Bryniarska
Financed by the National Science Center (NCN) -
Grant Joint Programme – Neurodegenerative Disease Research (JPND) , Professor Agnieszka Basta - Kaim, PhD
EpiAD: Effect of early and adult-life stress on the brain epigenome: relevance for the occurrence of Alzheimer’s Disease and Diabetes-related dementia. Professor Agnieszka Basta - Kaim, PhD -
The project of Alzheimer's Association: Drug Development of Pro-resolving ALX/FPR2 Agonists for Alzheimer’s Disease., Professor Agnieszka Basta - Kaim, PhD
Professor Agnieszka Basta-Kaim, PhD (Poland), professor Enza Lacivita, PhD (Italy), professor Lars-Ove Branderburg, PhD (Germany)
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HARMONIA 9. Modulation of inflammatory processes using new agonists of the formyl peptide receptors ALX/FPR2 as a new therapeutic strategy of depression., Professor Agnieszka Basta - Kaim, PhD
Grant NCN HARMONIA 9 2017/26/M/NZ7/01048; 2018.05.24-2022.05.23
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, Katarzyna Głombik, PhD
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OPUS 10. The role of the neuron-microglia CX3CL1-CX3CR1 and CD200-CD200R protein systems in molecular mechanisms of antipsychotic drug actions: in vivo and in vitro study in the neurodevelopmental models of schizophrenia., Professor Agnieszka Basta - Kaim, PhD
Grant NCN OPUS 10 2015/19/B/NZ7/02394; 2016.07.20-2021.07.19
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The role of the inflammasome NLRP3 in the mechanisms of antidepressant drugs action - studies in the animal model of depression, Ewa Trojan, PhD
Head of the project: dr Ewa Trojan, NCN 2015/17/N/NZ7/00924 (2016.03.24-2020.03.23) -
PRLEUDIUM 7: Molecular mechanism of action of antidepressant drugs in the in vitro model of contact allergy in the human cell line HaCat and mouse dendritic precursor JAWSII cells., Katarzyna Curzytek - Malicka, PhD
Grant NCN PRELUDIUM 7, 2014/13/N/NZ6/00639; 2015.03.10-2019.03.09
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The impact of maternal diabetes on inflammasome NLRP3 activation in the offspring brain, Katarzyna Głombik, PhD
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Excellence Award for Poster Presentation at the 35th European College of Neuropsychopharmacology (ECNP) Congress, 2022, Vienna, Austria, Kinga Tylek, PhD
Saturday, 15 October 2022 -
Team Scientific Award of the Division of Medical Sciences of the Polish Academy of Sciences for a series of publications entitled "The importance of dysfunction of selected neuronal and microglial proteins in the prenatal period in the pathomechanisms of schizophrenia – studies in neurodevelopmental models"., Professor Agnieszka Basta - Kaim, PhD
Thursday, 25 November 2021 -
3rd place in the competition for a popular science article for young scientists of the Maj Institute of Pharmacology PAS: "Feel the force around you" - how do physical interactions affect cells?, Natalia Bryniarska-Kubiak, PhD
Thursday, 30 September 2021 -
The "Scientist of the Future 2021" award in the category: Science for a better life in the future, Natalia Bryniarska-Kubiak, PhD
Tuesday, 28 September 2021 -
Research internship scholarship awarded through the STER – Internationalization of Doctoral Schools program to complete a research internship in the Department of Pharmacy at the University of Bari (Italy), Kinga Tylek, PhD
Monday, 6 September 2021 -
Travel Grant ENCODS 2021, Federation of European Neuroscience Societies (FENS) Glasgow, United Kingdom, Kinga Tylek, PhD
Friday, 4 June 2021 -
Scholarship of the President of the Polish Academy of Sciences, Natalia Bryniarska-Kubiak, PhD
Monday, 30 November 2020 -
Scholarship for the best PhD students at the Maj Institute of Pharmacology, Polish Academy of Sciences (2020/2021), Natalia Bryniarska-Kubiak, PhD
Friday, 13 November 2020 -
Laureate of the competition organized by "Pharmacological reports" and director of May Institute of Pharmacology Polish Academy of Sciences for the best draft of review article, Natalia Bryniarska-Kubiak, PhD
Tuesday, 10 November 2020 -
Scholarship of the Minister of Science and Higher Education for outstanding young scientists, Katarzyna Głombik, PhD
Monday, 15 June 2020 -
The best work in the Pharmacy and Pharmacology session during the 10th National Conference on Advence in Biomedical Research in Warsaw, Natalia Bryniarska-Kubiak, PhD
Saturday, 30 November 2019 -
The main prize of Professor Kazimierz Ostrowski for the best work presented during the 10th National Conference on Advences in Biomedical Research in Warsaw, Natalia Bryniarska-Kubiak, PhD
Saturday, 30 November 2019 -
Neuron of The Audience: Best Poster on 9th Annual Conference Aspects of Neuroscience in Warsaw, Natalia Bryniarska-Kubiak, PhD
Sunday, 24 November 2019 -
Scholarship for the best PhD students at the Maj Institute of Pharmacology Polish Academy of Sciences (2019/2020), Natalia Bryniarska-Kubiak, PhD
Thursday, 7 November 2019 -
3rd place in the competition for a popular science article for young scientists of the Polish Academy of Sciences, Natalia Bryniarska-Kubiak, PhD
Friday, 27 September 2019
Head
E-mail: basta@if-pan.krakow.pl
Professor Agnieszka Basta - Kaim, PhD
Phone number: +48 12 6623273E-mail: basta@if-pan.krakow.pl
interests
techniques
- colorometric evaluation of macrophage activity
- eleveted zero test
- eozynophilic test
- genotyping
- Griess test
- HPLC UV
- hypoosmotic test
- immune cells tissue cultures
- in vitro transfection
- liquid chromatography
- Morris water maze
- neurochemically specific lesions
- prepulse inhibition
- protein microarrays
- resident intruder paradigm
keywords
- 6-OHDA
- Alzheimer disease
- amyloid
- animal models
- apoptosis
- behavioural analysis
- Bipolar disorder
- chemokines
- confocal microscopy
- cytokines
- depression
- differentiation
- epilepsy
- extracellular matrix
- fluorescent microscopy
- G-protein coupled receptors
- genetics
- glia
- hippocampus
- hormones
- hypoxia
- immobilization stress
- immune system
- inflammation
- ischemia
- ischemia
- L-DOPA
- microglia
- microglia polarization
- mitochondrial proteins
- molecular biology
- neurodegeneration
- neurodevelopmental models
- neuroendocrine regulation
- neuroimaging
- neurology
- neuroprotection
- neurotoxicity
- Parkinson's disease
- pharmacotherapy
- plant polyphenols
- rat
- schizophrenia
- signaling proteins
- stem cells
- stress
- stroke
