Department of Drug Addiction Pharmacology
Head:
Professor Małgorzata Filip
Research staff:
Professor Edmund Przegaliński MD PhD, Małgorzata Frankowska PhD, Karolina Wydra-Kolarska PhD, Irena Smaga-Maślanka PhD, Dawid Gawliński, PhD
Technical staff / specialists:
Teresa Piwowarczyk, Agata Suder, Renata Pieniążek
PhD students:
Kinga Gawlińska MSc, Kacper Witek MSc
In our research, we use virtually all available research methods that visualize different stages of drug addiction process (initiation, prolonged drug use, craving and other withdrawal symptoms, relapses). The scope of our research includes animal models (experimental depression, transgenic animals), pharmacological manipulations (e.g. lesions, intrastructural and peripheral drug application, injections of selective receptor ligands), biochemical analyzes (changes in receptor and enzyme expression, synaptic and tissue levels of neurotransmitters / neuromodulators) and molecular analysis (mitochondrial DNA (mtDNA), gene and miRNA expression, epigenetic analysis).
We closely cooperate with a number of scientific units in Poland (Department of Pharmacodynamics, Faculty of Pharmacy - Medical University of Warsaw, Department of Pharmacology and Pharmacodynamics, Faculty of Pharmacy - Medical University of Lublin) and abroad (Department of Nervous System Research - Karolinska Institutet, Faculty of Pharmacy - University of Ferrara, Department of Pharmacological and Biomolecular Research - University of Milan, Department of Psychiatry and Psychotherapy - University of Friedrich Alexander in Erlangen-Nürnberg).
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Sex-specific effects of different types of prenatal stress on foetal testosterone levels and NMDA expression in mice.
Liubov S Kalinichenko, Irena Smaga, Malgorzata Filip, Bernd Lenz, Johannes Kornhuber, Christian P Müller
Behavioural brain research, 10.1016/j.bbr.2022.114225 S0166-4328(22)00494-6
PMID:36435218 -
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Joanna Jastrzębska, Małgorzata Frankowska, Irena Smaga, Magdalena Hubalewska-Mazgaj, Agata Suder, Renata Pieniążek, Edmund Przegaliński, Małgorzata Filip
Pharmacological reports : PR, 10.1007/s43440-022-00428-2
PMID:36374478 -
Cocaine and Its Abstinence Condition Modulate Striatal and Hippocampal Wnt Signaling in a Male Rat Model of Drug Self-Administration.
Dawid Gawliński, Kinga Gawlińska, Małgorzata Frankowska, Małgorzata Filip
International journal of molecular sciences, 14011 10.3390/ijms232214011
PMID:36430488 -
Novel Dopamine Transporter Inhibitor, CE-123, Ameliorates Spatial Memory Deficits Induced by Maternal Separation in Adolescent Rats: Impact of Sex.
Pawel Grochecki, Irena Smaga, Paulina Surowka, Marta Marszalek-Grabska, Predrag Kalaba, Vladimir Dragacevic, Patrycja Kotlinska, Malgorzata Filip, Gert Lubec, Jolanta H Kotlinska
International journal of molecular sciences, 10718 10.3390/ijms231810718
PMID:36142621 -
A High-Sugar Diet Consumption, Metabolism and Health Impacts with a Focus on the Development of Substance Use Disorder: A Narrative Review.
Kacper Witek, Karolina Wydra, Małgorzata Filip
Nutrients, 2940 10.3390/nu14142940
PMID:35889898 -
Maternal Separation Alters Ethanol Drinking and Reversal Learning Processes in Adolescent Rats: The Impact of Sex and Glycine Transporter Type 1 (GlyT1) Inhibitor.
Joanna Filarowska-Jurko, Lukasz Komsta, Irena Smaga, Paulina Surowka, Marta Marszalek-Grabska, Pawel Grochecki, Dorota Nizio, Malgorzata Filip, Jolanta H Kotlinska
International journal of molecular sciences, 5350 10.3390/ijms23105350
PMID:35628160 -
Increased density and antagonistic allosteric interactions in A2AR-D2R heterocomplexes in extinction from cocaine use, lost in cue induced reinstatement of cocaine seeking.
Wilber Romero-Fernandez, Karolina Wydra, Dasiel O Borroto-Escuela, Joanna Jastrzębska, Zilong Zhou, Malgorzata Frankowska, Malgorzata Filip, Kjell Fuxe
Pharmacology, biochemistry, and behavior, S0091-3057(22)00054-5 10.1016/j.pbb.2022.173375
PMID:35307414 -
Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males.
Liubov S Kalinichenko, Christiane Mühle, Tianye Jia, Felix Anderheiden, Maria Datz, Anna-Lisa Eberle, Volker Eulenburg, Jonas Granzow, Martin Hofer, Julia Hohenschild, Sabine E Huber, Stefanie Kämpf, Georgios Kogias, Laura Lacatusu, Charlotte Lugmair, Stephen Mbu Taku, Doris Meixner, Nina-Kristin Sembritzki, Marc Praetner, Cosima Rhein, Christina Sauer, Jessica Scholz, Franziska Ulrich, Florian Valenta, Esther Weigand, Markus Werner, Nicole Tay, Conor J Mc Veigh, Jana Haase, An-Li Wang, Laila Abdel-Hafiz, Joseph P Huston, Irena Smaga, Malgorzata Frankowska, Malgorzata Filip, Anbarasu Lourdusamy, Philipp Kirchner, Arif B Ekici, Lena M Marx, Neeraja Puliparambil Suresh, Renato Frischknecht, Anna Fejtova, Essa M Saied, Christoph Arenz, Aline Bozec, Isabel Wank, Silke Kreitz, Andreas Hess, Tobias Bäuerle, Maria Dolores Ledesma, Daniel N Mitroi, André M Miranda, Tiago Gil Oliveira, Bernd Lenz, Gunter Schumann, Johannes Kornhuber, Christian P Müller
Cerebral cortex (New York, N.Y. : 1991), bhac106 10.1093/cercor/bhac106
PMID:35296883 -
Alteration of Ethanol Reward by Prior Mephedrone Exposure: The Role of Age and Matrix Metalloproteinase-9 (MMP-9).
Pawel Grochecki, Irena Smaga, Marta Marszalek-Grabska, Malgorzata Lopatynska-Mazurek, Tymoteusz Slowik, Ewa Gibula-Tarlowska, Ewa Kedzierska, Joanna Listos, Malgorzata Filip, Jolanta H Kotlinska
International journal of molecular sciences, 2122 10.3390/ijms23042122
PMID:35216236 -
Understanding the Links among Maternal Diet, Myelination, and Depression: Preclinical and Clinical Overview.
Irena Smaga
Cells, 540 10.3390/cells11030540
PMID:35159347 -
Enhancement of the GluN2B subunit of glutamatergic NMDA receptors in rat brain areas after cocaine abstinence.
Irena Smaga, Karolina Wydra, Agata Suder, Marek Sanak, Lucia Caffino, Fabio Fumagalli, Małgorzata Filip
Journal of psychopharmacology (Oxford, England), 10.1177/02698811211048283
PMID:34587833 -
Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects.
Liubov S Kalinichenko, Christiane Mühle, Tianye Jia, Felix Anderheiden, Maria Datz, Anna-Lisa Eberle, Volker Eulenburg, Jonas Granzow, Martin Hofer, Julia Hohenschild, Sabine E Huber, Stefanie Kämpf, Georgios Kogias, Laura Lacatusu, Charlotte Lugmair, Stephen Mbu Taku, Doris Meixner, Nina Tesch, Marc Praetner, Cosima Rhein, Christina Sauer, Jessica Scholz, Franziska Ulrich, Florian Valenta, Esther Weigand, Markus Werner, Nicole Tay, Conor J Mc Veigh, Jana Haase, An-Li Wang, Laila Abdel-Hafiz, Joseph P Huston, Irena Smaga, Malgorzata Frankowska, Malgorzata Filip, Anbarasu Lourdusamy, Philipp Kirchner, Arif B Ekici, Lena M Marx, Neeraja Puliparambil Suresh, Renato Frischknecht, Anna Fejtova, Essa M Saied, Christoph Arenz, Aline Bozec, Isabel Wank, Silke Kreitz, Andreas Hess, Tobias Bäuerle, Maria Dolores Ledesma, Daniel N Mitroi, André M Miranda, Tiago G Oliveira, Erich Gulbins, Bernd Lenz, Gunter Schumann, Johannes Kornhuber, Christian P Müller
Molecular psychiatry, 10.1038/s41380-021-01304-w
PMID:34584229 -
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Wojciech Krzeptowski, Lucyna Walkowicz, Ewelina Krzeptowska, Edyta Motta, Kacper Witek, Joanna Szramel, Terence Al Abaquita, Zbigniew Baster, Zenon Rajfur, Ezio Rosato, Vassilis Stratoulias, Tapio I Heino, Elżbieta M Pyza
Frontiers in physiology, 10.3389/fphys.2021.705183
PMID:34646147 -
Alteration of the Early Development Environment by Maternal Diet and the Occurrence of Autistic-like Phenotypes in Rat Offspring.
Kinga Gawlińska, Dawid Gawliński, Ewelina Kowal-Wiśniewska, Małgorzata Jarmuż-Szymczak, Małgorzata Filip
International journal of molecular sciences, 9662 10.3390/ijms22189662
PMID:34575826 -
The coming together of allosteric and phosphorylation mechanisms in the molecular integration of A2A heteroreceptor complexes in the dorsal and ventral striatal-pallidal GABA neurons.
Dasiel O Borroto-Escuela, Luca Ferraro, Sarah Beggiato, Manuel Narváez, Ramon Fores-Pons, Jose E Alvarez-Contino, Karolina Wydra, Małgorzata Frankowska, Michael Bader, Małgorzata Filip, Kjell Fuxe
Pharmacological reports : PR, 10.1007/s43440-021-00314-3
PMID:34426901
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Maternal obesity as a risk factor of autism spectrum disorder in offspring - in search of the role of the gut microbiota and the prevention strategies, Dawid Gawliński, PhD
GRANT NCN no. 2021/43/B/NZ5/02552 (OPUS 22) -
The effect of omega-3 fatty acid-enriched diet on the myelination impairment and the depression-like phenotype induced by maternal high-fat diet during pregnancy and lactation in offspring. NCN, SONATA 16, UMO-2020/39/D/NZ5/02581, Irena Smaga-Maślanka, PhD
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Transgenerational effects of maternal high-fat diet on morphological and epigenetic changes within the prefrontal cortex in offspring, Dawid Gawliński, PhD
GRANT NCN no. 2020/04/X/NZ7/02058 (MINIATURA 4) -
The effect of high-fat mother's diet during pregnancy and lactation on epigenetic changes within the gene encoding the cannabinoid receptor CB1 (CNR1) in the brain of offspring. NCN, MINIATURA 4, 2020/04/X/NZ7/00049 , Irena Smaga-Maślanka, PhD
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, Professor Małgorzata Filip, PhD
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, Professor Małgorzata Filip, PhD
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Effects and potential mechanisms of action of dislufiram and nepicastat in morphine dependence in laboratory animal , Małgorzata Frankowska, PhD
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, Professor Małgorzata Filip, PhD
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The role of the mGlu5-D2 heterodimeric receptor complexes in the extinction of drug seeking behavior associated with dependents to psichostimulants (cocaine and MDMA): behavioral and biomolecular analyses in rats , Małgorzata Frankowska, PhD
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Understanding cocaine addiction. A2A-D2 and A1-D1 heteromers as novel targets for cocaine action, Małgorzata Frankowska, PhD
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, Irena Smaga-Maślanka, PhD
Tuesday, 31 January 2023 -
, Małgorzata Frankowska, PhD
Monday, 12 December 2022 -
Prof. Aleksander Szczygieł Prize of The Polish Society of Nutritional Sciences for the best research work published in 2021, Dawid Gawliński, PhD
Friday, 21 October 2022 -
, Małgorzata Frankowska, PhD
Monday, 10 January 2022 -
Research fellowship within Bekker Programme of the Polish National Agency for Academic Exchange for postdoctoral training at Boston Children's Hospital, Harvard Medical School, Dawid Gawliński, PhD
Sunday, 12 December 2021 -
, Irena Smaga-Maślanka, PhD
Tuesday, 9 June 2020 -
, Irena Smaga-Maślanka, PhD
Monday, 3 June 2019 -
, Irena Smaga-Maślanka, PhD
Tuesday, 19 March 2019 -
, Małgorzata Frankowska, PhD
Thursday, 20 December 2018 -
Awarded internship founded by Leading National Research Center (KNOW), Institute of Pharmacology PAS, Małgorzata Frankowska, PhD
Wednesday, 8 February 2017 -
, Małgorzata Frankowska, PhD
Friday, 1 April 2011 -
, Małgorzata Frankowska, PhD
Friday, 1 October 2010 -
, Małgorzata Frankowska, PhD
Tuesday, 31 March 2009 -
, Małgorzata Frankowska, PhD
Monday, 31 March 2008 -
, Małgorzata Frankowska, PhD
Wednesday, 31 January 2007
techniques
keywords
- adenosine
- allosteric modulation
- animal models
- antidepressants
- autism
- behavioural analysis
- CB1 receptor
- cocaine
- cognitive functions
- depression
- DNA methylation
- drug addiction
- enriched environment
- epigenetics
- escitalopram
- frontal cortex
- G-protein coupled receptors
- GABAB receptors
- imipramine
- MDMA
- miRNA
- mirtazapine
- motivation
- neuropeptides
- pharmacotherapy
- rat
- reboxetine
- sex