Miniatura 5 results

Dr Katarzyna Rafa-Zabłocka has been awarded a grant from the National Science Centre (NCN) MINIATURA 5 for a project entitled: “Exploiting of CRISPR/Cas9 gene-editing tool for the engineering of models with selective double deletion CREB/CREM in chosen brain structure.”

Studies involving CREB deficient animals often neglected increase in expression of CREM protein induced by the lack of CREB, which phenomenon could have been partly responsible for unexpected results of these experiments. The new model proposed in the MINIATURA project by utilizing CRISPR/Cas9 system will enable selective and simultaneous deletion of both genes CREB and CREM in a chosen brain structure. Animals with CREB/CREM deletion may become a new tool in studies on CREB function not only in the pathogenesis of depression, but also in drug addiction, anxiety, learning and memory etc.

Congratulations!