Miniatura 5 results

Dr. Natalia Malikowska-Racia has been awarded a grant from the National Science Centre (NCN) MINIATURA 5 for a project:“Pharmacotherapy of apathy and motivation disorders: studying the effects of chronic naltrexone treatment on motivation in rats”.
Apathy manifests as a lack of motivation and decreased activity that may contribute to depressive disorders. Nowadays, the effective and safe pharmacotherapy of motivation disorders is unavailable, yet some observations suggest that treatment with naltrexone may benefit apathy. Research indicates that this phenomenon involves mechanisms different than opioid receptors antagonism that underlies the clinical use of naltrexone in addictions therapy. The study “Pharmacotherapy of apathy and motivation disorders: studying the effects of chronic naltrexone treatment on motivation in rats” aims to evaluate the potential effect of chronic treatment with naltrexone on motivation in rats and determine possible protein pathways underlying driving this effect.

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