Agnieszka Wnuk, PhD

Position
Adjunct

Department
Department of Drug Addiction Pharmacology

wnuk@if-pan.krakow.pl

+48 12 6623338

room: 341

Prenatal Exposure to Triclocarban Impairs ESR1 Signaling and Disrupts Epigenetic Status in Sex-Specific Ways as Well as Dysregulates the Expression of Neurogenesis- and Neurotransmitter-Related Genes in the Postnatal Mouse Brain. Agnieszka Wnuk, Joanna Rzemieniec, Karolina Przepiórska, Bernadeta Angelika Pietrzak, Marzena Maćkowiak, Małgorzata Kajta
International journal of molecular sciences, 13121 10.3390/ijms222313121
PMID:34884933
Posttreatment Strategy Against Hypoxia and Ischemia Based on Selective Targeting of Nonnuclear Estrogen Receptors with PaPE-1. A Wnuk, K Przepiórska, B A Pietrzak, M Kajta
Neurotoxicity research, 10.1007/s12640-021-00441-y
PMID:34797527
Is the commonly used UV filter benzophenone-3 a risk factor for the nervous system? Agnieszka Wnuk, Małgorzata Kajta
Acta biochimica Polonica, 10.18388/abp.2020_5741
PMID:34351731
Post-Treatment with Amorfrutin B Evokes PPARγ-Mediated Neuroprotection against Hypoxia and Ischemia. Agnieszka Wnuk, Karolina Przepiórska, Bernadeta A Pietrzak, Małgorzata Kajta
Biomedicines, 854 10.3390/biomedicines9080854
PMID:34440058
Selective Targeting of Non-nuclear Estrogen Receptors with PaPE-1 as a New Treatment Strategy for Alzheimer's Disease. Agnieszka Wnuk, Karolina Przepiórska, Joanna Rzemieniec, Bernadeta Pietrzak, Małgorzata Kajta
Neurotoxicity research, 10.1007/s12640-020-00289-8
PMID:33025361
Neuroprotective effect of 3,3'-Diindolylmethane against perinatal asphyxia involves inhibition of the AhR and NMDA signaling and hypermethylation of specific genes. J Rzemieniec, E Bratek, A Wnuk, K Przepiórska, E Salińska, M Kajta
Apoptosis : an international journal on programmed cell death, 10.1007/s10495-020-01631-3
PMID:32816128
Autophagy-related neurotoxicity is mediated via AHR and CAR in mouse neurons exposed to DDE. Agnieszka Wnuk, Joanna Rzemieniec, Karolina Przepiórska, Julita Wesołowska, Anna Katarzyna Wójtowicz, Małgorzata Kajta
The Science of the total environment, S0048-9697(20)34121-8 10.1016/j.scitotenv.2020.140599
PMID:32721735
The neuroprotective action of 3,3'-diindolylmethane against ischemia involves an inhibition of apoptosis and autophagy that depends on HDAC and AhR/CYP1A1 but not ERα/CYP19A1 signaling. J Rzemieniec, A Wnuk, W Lasoń, W Bilecki, M Kajta
Apoptosis : an international journal on programmed cell death, 10.1007/s10495-019-01522-2
PMID:30778709
Glutathione Deficiency and Alterations in the Sulfur Amino Acid Homeostasis during Early Postnatal Development as Potential Triggering Factors for Schizophrenia-Like Behavior in Adult Rats. Magdalena Górny, Agnieszka Wnuk, Adrianna Kamińska, Kinga Kamińska, Grażyna Chwatko, Anna Bilska-Wilkosz, Małgorzata Iciek, Małgorzata Kajta, Zofia Rogóż, Elżbieta Lorenc-Koci
Molecules (Basel, Switzerland), E4253 10.3390/molecules24234253
PMID:31766654
Triclocarban impairs autophagy in neuronal cells and disrupts estrogen receptor signaling via hypermethylation of specific genes. M Kajta, J Rzemieniec, A Wnuk, W Lasoń
The Science of the total environment, S0048-9697(19)34809-0 10.1016/j.scitotenv.2019.134818
PMID:31706213
Prenatal Exposure to Benzophenone-3 Impairs Autophagy, Disrupts RXRs/PPARγ Signaling, and Alters Epigenetic and Post-Translational Statuses in Brain Neurons. Agnieszka Wnuk, Joanna Rzemieniec, Jakub Staroń, Ewa Litwa, Władysław Lasoń, Andrzej Bojarski, Małgorzata Kajta
Molecular neurobiology, 10.1007/s12035-018-1401-5
PMID:30402708
Triclocarban Disrupts the Epigenetic Status of Neuronal Cells and Induces AHR/CAR-Mediated Apoptosis. M Kajta, A Wnuk, J Rzemieniec, W Lason, M Mackowiak, E Chwastek, M Staniszewska, I Nehring, A K Wojtowicz
Molecular neurobiology, 10.1007/s12035-018-1285-4
PMID:30097849
Effects of exposure to 5-MeO-DIPT during adolescence on brain neurotransmission and neurotoxicity in adult rats. Karolina Noworyta-Sokołowska, Katarzyna Kamińska, Joanna Rzemieniec, Agnieszka Wnuk, Jakub Wojcieszak, Anna Maria Górska, Grzegorz Kreiner, Małgorzata Kajta, Krystyna Gołembiowska
Forensic toxicology, 10.1007/s11419-018-0433-x
PMID:30636982
The Effects of Exposure to Mephedrone During Adolescence on Brain Neurotransmission and Neurotoxicity in Adult Rats. Katarzyna Kamińska, Karolina Noworyta-Sokołowska, Anna Górska, Joanna Rzemieniec, Agnieszka Wnuk, Adam Wojtas, Grzegorz Kreiner, Małgorzata Kajta, Krystyna Gołembiowska
Neurotoxicity research, 10.1007/s12640-018-9908-0
PMID:29713996
Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons. Agnieszka Wnuk, Joanna Rzemieniec, Ewa Litwa, Władysław Lasoń, Małgorzata Kajta
The Journal of steroid biochemistry and molecular biology, S0960-0760(18)30103-1 10.1016/j.jsbmb.2018.04.016
PMID:29704544
Triclosan-Evoked Neurotoxicity Involves NMDAR Subunits with the Specific Role of GluN2A in Caspase-3-Dependent Apoptosis. Konrad A Szychowski, Agnieszka Wnuk, Joanna Rzemieniec, Małgorzata Kajta, Teresa Leszczyńska, Anna K Wójtowicz
Molecular neurobiology, 10.1007/s12035-018-1083-z
PMID:29675573
Steroid and Xenobiotic Receptor Signalling in Apoptosis and Autophagy of the Nervous System. Agnieszka Wnuk, Małgorzata Kajta
International journal of molecular sciences, E2394 10.3390/ijms18112394
PMID:29137141
Bazedoxifene and raloxifene protect neocortical neurons undergoing hypoxia via targeting ERα and PPAR-γ. J Rzemieniec, E Litwa, A Wnuk, W Lason, M Kajta
Molecular and cellular endocrinology, S0303-7207(17)30450-1 10.1016/j.mce.2017.08.014
PMID:28859903
Benzophenone-3 Impairs Autophagy, Alters Epigenetic Status, and Disrupts Retinoid X Receptor Signaling in Apoptotic Neuronal Cells. Agnieszka Wnuk, Joanna Rzemieniec, Władysław Lasoń, Wojciech Krzeptowski, Małgorzata Kajta
Molecular neurobiology, 10.1007/s12035-017-0704-2
PMID:28815487
Apoptosis Induced by the UV Filter Benzophenone-3 in Mouse Neuronal Cells Is Mediated via Attenuation of Erα/Pparγ and Stimulation of Erβ/Gpr30 Signaling. A Wnuk, J Rzemieniec, W Lasoń, W Krzeptowski, M Kajta
Molecular neurobiology, 10.1007/s12035-017-0480-z
PMID:28357806
Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling. Malgorzata Kajta, Agnieszka Wnuk, Joanna Rzemieniec, Ewa Litwa, Wladyslaw Lason, Agnieszka Zelek-Molik, Irena Nalepa, Zofia Rogóż, Adam Grochowalski, Anna K Wojtowicz
The Journal of steroid biochemistry and molecular biology, S0960-0760(17)30066-3 10.1016/j.jsbmb.2017.03.001
PMID:28263910
Dibutyl Phthalate (DBP)-Induced Apoptosis and Neurotoxicity are Mediated via the Aryl Hydrocarbon Receptor (AhR) but not by Estrogen Receptor Alpha (ERα), Estrogen Receptor Beta (ERβ), or Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Mouse Cortical Neurons. Anna K Wójtowicz, Konrad A Szychowski, Agnieszka Wnuk, Małgorzata Kajta
Neurotoxicity research, 10.1007/s12640-016-9665-x
PMID:27581038
Triclosan activates aryl hydrocarbon receptor (AhR)-dependent apoptosis and affects Cyp1a1 and Cyp1b1 expression in mouse neocortical neurons. Konrad A Szychowski, Agnieszka Wnuk, Małgorzata Kajta, Anna K Wójtowicz
Environmental research, S0013-9351(16)30302-4 10.1016/j.envres.2016.07.019
PMID:27474938
RXRα, PXR and CAR xenobiotic receptors mediate the apoptotic and neurotoxic actions of nonylphenol in mouse hippocampal cells. E Litwa, J Rzemieniec, A Wnuk, W Lason, W Krzeptowski, M Kajta
The Journal of steroid biochemistry and molecular biology, 10.1016/j.jsbmb.2015.11.018 S0960-0760(15)30144-8
PMID:26643981
The Crucial Involvement of Retinoid X Receptors in DDE Neurotoxicity. A Wnuk, J Rzemieniec, E Litwa, W Lasoń, W Krzeptowski, A K Wójtowicz, M Kajta
Neurotoxicity research, 10.1007/s12640-015-9572-6
PMID:26563996
Selective Aryl Hydrocarbon Receptor Modulator 3,3'-Diindolylmethane Impairs AhR and ARNT Signaling and Protects Mouse Neuronal Cells Against Hypoxia. J Rzemieniec, E Litwa, A Wnuk, W Lason, W Krzeptowski, M Kajta
Molecular neurobiology, 10.1007/s12035-015-9471-0
PMID:26476840
Apoptotic and neurotoxic actions of 4-para-nonylphenol are accompanied by activation of retinoid X receptor and impairment of classical estrogen receptor signaling. E Litwa, J Rzemieniec, A Wnuk, W Lason, W Krzeptowski, M Kajta
The Journal of steroid biochemistry and molecular biology, 10.1016/j.jsbmb.2014.07.014 S0960-0760(14)00145-9
PMID:25092517
Isomer-nonspecific action of dichlorodiphenyltrichloroethane on aryl hydrocarbon receptor and G-protein-coupled receptor 30 intracellular signaling in apoptotic neuronal cells. M Kajta, E Litwa, J Rzemieniec, A Wnuk, W Lason, A Zelek-Molik, I Nalepa, M Grzegorzewska-Hiczwa, K Tokarski, A Golas, E Guzik, A Grochowalski, K A Szychowski, A K Wojtowicz
Molecular and cellular endocrinology, 10.1016/j.mce.2014.05.008 S0303-7207(14)00150-6
PMID:24859647
Neuroprotective action of raloxifene against hypoxia-induced damage in mouse hippocampal cells depends on ERα but not ERβ or GPR30 signalling. J Rzemieniec, E Litwa, A Wnuk, W Lason, A Gołas, W Krzeptowski, M Kajta
The Journal of steroid biochemistry and molecular biology, 10.1016/j.jsbmb.2014.05.005 S0960-0760(14)00107-1
PMID:24846829
Amorfrutin B Protects Mouse Brain Neurons from Hypoxia/Ischemia by Inhibiting Apoptosis and Autophagy Processes Through Gene Methylation- and miRNA-Dependent Regulation. Karolina Przepiórska, Agnieszka Wnuk, Cordian Beyer, Małgorzata Kajta
,
PMID:36324052
Emerging Evidence on Membrane Estrogen Receptors as Novel Therapeutic Targets for Central Nervous System Pathologies. Agnieszka Wnuk, Karolina Przepiórska, Bernadeta Angelika Pietrzak, Małgorzata Kajta
,
PMID:36835454
Pre-reproductive stress in adolescent female rats alters maternal care and DNA methylation patterns across generations. Hiba Zaidan, Agnieszka Wnuk, Idan M Aderka, Malgorzata Kajta, Inna Gaisler-Salomon
,
PMID:37036738

More publications

Popular science article "Sunscreen cream - friend or foe?" Agnieszka Wnuk Link to the article

New post-treatment strategy against stroke and perinatal asphyxia – a novel approach based on a selective activation of membrane estrogen receptors mERα and mERβ, Agnieszka Wnuk, - 2022-07-11 - 2025-07-10
NCN SONATA Grant; 2021/43/D/NZ7/00633; 2022-2025. Ongoing.Principal Investigator of the grant: Agnieszka Wnuk, PhD
Neurotoxic effects of benzophenone-3 : the role of estrogen receptors and retinoid X receptor alpha. - 2015-02-26 - 2018-02-25
NCN PRELUDIUM Grant; 2014/13/N/NZ4/04845; 2015-2018Principal Investigator of the project: Agnieszka Wnuk, MScThe Scientific Supervisor of the project: Małgorzata Kajta, PhD

2024-06-25
Team Award of the V Faculty of Medical Sciences of the Polish Academy of Sciences for a series of publications.
2018-11-22
Stipends START 2018 granted by The Foundation for Polish Science (FNP) stipends for the young scientists
2018-05-26
The second place in the competition for a popular-science article "Sunscreen cream - friend or foe?"- the Organizer: Directorate of the IF PAS in Krakow
2017-11-15

Agnieszka Wnuk, PhD

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