Agnieszka Wnuk, MSc
The Effects of Exposure to Mephedrone During Adolescence on Brain Neurotransmission and Neurotoxicity in Adult Rats.
Katarzyna Kamińska, Karolina Noworyta-Sokołowska, Anna Górska, Joanna Rzemieniec, Agnieszka Wnuk, Adam Wojtas, Grzegorz Kreiner, Małgorzata Kajta, Krystyna Gołembiowska
Neurotoxicity research, 10.1007/s12640-018-9908-0
Prenatal exposure to benzophenone-3 (BP-3) induces apoptosis, disrupts estrogen receptor expression and alters the epigenetic status of mouse neurons.
Agnieszka Wnuk, Joanna Rzemieniec, Ewa Litwa, Władysław Lasoń, Małgorzata Kajta
The Journal of steroid biochemistry and molecular biology, S0960-0760(18)30103-1 10.1016/j.jsbmb.2018.04.016
Triclosan-Evoked Neurotoxicity Involves NMDAR Subunits with the Specific Role of GluN2A in Caspase-3-Dependent Apoptosis.
Konrad A Szychowski, Agnieszka Wnuk, Joanna Rzemieniec, Małgorzata Kajta, Teresa Leszczyńska, Anna K Wójtowicz
Molecular neurobiology, 10.1007/s12035-018-1083-z
Steroid and Xenobiotic Receptor Signalling in Apoptosis and Autophagy of the Nervous System.
Agnieszka Wnuk, Małgorzata Kajta
International journal of molecular sciences, E2394 10.3390/ijms18112394
Bazedoxifene and raloxifene protect neocortical neurons undergoing hypoxia via targeting ERα and PPAR-γ.
J Rzemieniec, E Litwa, A Wnuk, W Lason, M Kajta
Molecular and cellular endocrinology, S0303-7207(17)30450-1 10.1016/j.mce.2017.08.014
Neurotoxic effects of benzophenone-3 : the role of estrogen receptors and retinoid X receptor alpha. - 2015-02-26 - 2018-02-25
Benzophenone-3 (BP-3) is one of the most commonly used UV filters, which is demonstrated as a hormonally active substance in vitro studies. However, data on the effects of benzophenone-3 on the nervous system are scarce. Especially little is known about the impact of BP-3 on individual receptors that are strongly associated with brain development. The main idea of this project is to investigate the neurotoxic effect of benzophenone-3 on neuronal cells and to establish molecular basis of its activity, with particular emphasis on estrogen receptors and retinoid X receptor alpha. Basic research hypothesis assumes that benzophenone-3 induces a neurotoxic effect and initiates the apoptotic process in the neuronal cells simultaneously modifying activity of the estrogen receptors (ERα, ERβ, GPR30) and retinoid X receptor alpha (RXRα) as well as makes changes in DNA methylation profile.