Department of Neuropsychopharmacology
- stereotaxic brain operations in rats and intracerebral administration of compounds
- behavioral methods:- automatic measurement of locomotor activity, action tremor and other forms of rat motor behavior in actometers and tremorometers- automatic measurement of asymmetric behavior in rats following unilateral damage of the dopamine system (rotameters)- observation of rats’ behavior: catalepsy test (a model of akinesia, bradykinesia), measurement of tremulous jaw movements (a model of parkinsonian tremor), cylinder test (motor coordination test), dyskinesias
- running as a regular physical exercise training in automatic runways
- histological methods: histological and immunohistochemical staining of brain sections, light and fluorecence microscopy, stereology, morphology anlysis, Sholl method
- biochemical methods: HPLC, brain microdialysis, autoradiography of receptors and transporters, measurement of energy substrates concentration in tissues and blood plasma
- molecular methods: Western blot, in situ hybridization, PCR, analysis of the mitochondrial respiratory complexes activity, 2-dimetional electrophoresis, DIGE
- computer imaging of brain sections, densitometry
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Introduction to the Special Section on
Katarzyna Głombik, Katarzyna Kuter-Nowak
Pharmacological reports : PR, 10.1007/s43440-022-00421-9
PMID:36149597 -
The influence of preconditioning with low dose of LPS on paraquat-induced neurotoxicity, microglia activation and expression of α-synuclein and synphilin-1 in the dopaminergic system.
Katarzyna Z Kuter, Maria Śmiałowska, Krystyna Ossowska
Pharmacological reports : PR, 10.1007/s43440-021-00340-1
PMID:34762280 -
Beyond the GFAP-Astrocyte Protein Markers in the Brain.
Agnieszka M Jurga, Martyna Paleczna, Justyna Kadluczka, Katarzyna Z Kuter
Biomolecules, 1361 10.3390/biom11091361
PMID:34572572 -
Antiparkinsonian-like effects of CPL500036, a novel selective inhibitor of phosphodiesterase 10A, in the unilateral rat model of Parkinson's disease.
Tomasz Lenda, Krystyna Ossowska, Klemencja Berghauzen-Maciejewska, Mikołaj Matłoka, Jerzy Pieczykolan, Maciej Wieczorek, Jolanta Konieczny
European journal of pharmacology, S0014-2999(21)00614-2 10.1016/j.ejphar.2021.174460
PMID:34469756 -
Increased Beta-Hydroxybutyrate Level Is Not Sufficient for the Neuroprotective Effect of Long-Term Ketogenic Diet in an Animal Model of Early Parkinson's Disease. Exploration of Brain and Liver Energy Metabolism Markers.
Katarzyna Z Kuter, Łukasz Olech, Urszula Głowacka, Martyna Paleczna
International journal of molecular sciences, 7556 10.3390/ijms22147556
PMID:34299176 -
Overview of General and Discriminating Markers of Differential Microglia Phenotypes.
Agnieszka M Jurga, Martyna Paleczna, Katarzyna Z Kuter
Frontiers in cellular neuroscience, 10.3389/fncel.2020.00198
PMID:32848611 -
The role of glia in Parkinson's disease: Emerging concepts and therapeutic applications.
Katarzyna Z Kuter, M Angela Cenci, Anna R Carta
Progress in brain research, S0079-6123(20)30021-2 10.1016/bs.pbr.2020.02.004
PMID:32247363 -
Inhibition of Excessive Glutamatergic Transmission in the Ventral Thalamic Nuclei by a Selective Adenosine A1 Receptor Agonist, 5'-Chloro-5'-Deoxy-(±)-ENBA Underlies its Tremorolytic Effect in the Harmaline-Induced Model of Essential Tremor.
Barbara Kosmowska, Krystyna Ossowska, Jolanta Konieczny, Tomasz Lenda, Klemencja Berghauzen-Maciejewska, Jadwiga Wardas
Neuroscience, S0306-4522(20)30003-8 10.1016/j.neuroscience.2019.12.045
PMID:31935489 -
Zona incerta as a therapeutic target in Parkinson's disease.
Krystyna Ossowska
Journal of neurology, 10.1007/s00415-019-09486-8
PMID:31375987 -
Increased energetic demand supported by mitochondrial electron transfer chain and astrocyte assistance is essential to maintain the compensatory ability of the dopaminergic neurons in an animal model of early Parkinson's disease.
Katarzyna Z Kuter, Łukasz Olech, Norbert A Dencher
Mitochondrion, S1567-7249(18)30095-3 10.1016/j.mito.2018.12.002
PMID:30578987 -
Astrocyte support is important for the compensatory potential of the nigrostriatal system neurons during early neurodegeneration.
Katarzyna Kuter, Łukasz Olech, Urszula Głowacka, Martyna Paleczna
Journal of neurochemistry, 10.1111/jnc.14605
PMID:30295916 -
Interactions of the tricyclic antidepressant drug amitriptyline with L-DOPA in the striatum and substantia nigra of unilaterally 6-OHDA-lesioned rats. Relevance to motor dysfunction in Parkinson's disease.
Kinga Kamińska, Tomasz Lenda, Jolanta Konieczny, Jadwiga Wardas, Elżbieta Lorenc-Koci
Neurochemistry international, S0197-0186(18)30177-3 10.1016/j.neuint.2018.10.004
PMID:30290201 -
Diverse action of repeated corticosterone treatment on synaptic transmission, neuronal plasticity, and morphology in superficial and deep layers of the rat motor cortex.
Joanna Kula, Anna Gugula, Anna Blasiak, Bartosz Bobula, Joanna Danielewicz, Alan Kania, Grzegorz Tylko, Grzegorz Hess
Pflugers Archiv : European journal of physiology, 10.1007/s00424-017-2036-5
PMID:28748319 -
Depressive-like neurochemical and behavioral markers of Parkinson's disease after 6-OHDA administered unilaterally to the rat medial forebrain bundle.
Kinga Kamińska, Tomasz Lenda, Jolanta Konieczny, Anna Czarnecka, Elżbieta Lorenc-Koci
Pharmacological reports : PR, S1734-1140(17)30231-1 10.1016/j.pharep.2017.05.016
PMID:28843848 -
Low-basicity 5-HT7 Receptor Agonists Synthesized Using the van Leusen Multicomponent Protocol.
Adam S Hogendorf, Agata Hogendorf, Rafał Kurczab, Grzegorz Satała, Tomasz Lenda, Maria Walczak, Gniewomir Latacz, Jadwiga Handzlik, Katarzyna Kieć-Kononowicz, Joanna M Wierońska, Monika Woźniak, Paulina Cieślik, Ryszard Bugno, Jakub Staroń, Andrzej J Bojarski
Scientific reports, 10.1038/s41598-017-00822-4
PMID:28473721
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Kuter, Cenci, Carta, The role of glia in Parkinson's disease: Emerging concepts and therapeutic applications, Progress in Brain Research Volume 252, 2020, Pages 131-168
Kuter K.Z., Cenci M.A., Carta A.R.
"The role of glia in Parkinson's disease: Emerging concepts and therapeutic applications"
Progress in Brain Research Volume 252, 2020, Pages 131-168
part of Recent Advances in Parkinson's Disease, edited by Björklund and CenciElsevier -
Astrocytes and microglia in Parkinson’s disease and its animal models. In: The Neuroscience of Parkinson's Disease. Vol 2. Genetics, neurology, behavior, and diet in Parkinson’s disease, 2020, Chapter 6, pp 83-101
Katarzyna Kuter
Astrocytes and microglia in Parkinson’s disease and its animal models. In: The Neuroscience of Parkinson's Disease. Vol 2. Genetics, neurology, behavior, and diet in Parkinson’s disease, 2020, Chapter 6, pp 83-101, Editors: Colin Martin and Victor Preedy, ISBN: 978-0-12-815950-7, published by Academic Press, Imprint of Elsevier, Published Date: 18th September 2020
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grant NCN OPUS18 2019/35/B/NZ7/02862 Physical exercise as a natural mechanism inducing neuroregeneration. Search for the new protein markers and therapeutic targets for Parkinson’s disease, Katarzyna Kuter - Nowak, PhD
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, Katarzyna Kuter - Nowak, PhD
NCN grant, OPUS 14 [2018-08-03 - 2021-08-02]
Title: "How microglia-astrocyte interaction affects neuronal functioning
in the dopaminergic system. Analysis of protective potential of drugs changing the glial phenotype"
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, Katarzyna Kuter - Nowak, PhD
“MOBILNOSC PLUS” scholarship sponsored by Polish Ministry of Science and Higher Education.
Title: „Protective role of astrocytes in the process of neurodegeneration of dopaminergic cells and during functional compensation of this process. Analysis of function and architecture of mitochondrial oxphos complexes and supercomplexes in animal models of early Morbus Parkinson.”
Performed during three 6 month visits at Technische Universität Darmstadt, Darmstadt, Germany in group of Prof. Norbert A. Dencher. -
NCN grant, OPUS 3, Katarzyna Kuter - Nowak, PhD
OPUS 3 grant nr 2012/05/B/NZ4/02599 financed by National Science Centre (NCN).
Title: „The role of astrocytes and cellular metabolism in functional compensation of degeneration of dopaminergic system in threats brain. Analysis of expression of AMPK and energy sensing proteins in aspect of Parkinson's disease.”
Performed in the Institute of Pharmacology, Polish Academy of Sciences – project leader.
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Team Scientific Award of the 5th Medical Sciences PAS for a series of 3 publications "The role of astrocytes in mechanisms compensating for the degeneration of dopaminergic neurons and in the regulation of cellular energy of the black-striatal system in an animal model of early Parkinson's disease"., Katarzyna Kuter - Nowak, PhD
Wednesday, 11 December 2019 -
Award for publication woth high IF in 2018 granted by the Head of the Institute of Pharmacology, Katarzyna Kuter - Nowak, PhD
Monday, 30 November -0001
techniques
keywords
- 6-OHDA
- adenosine
- adenosine receptors
- animal models
- antidepressants
- behavioural analysis
- biomarker
- cerebellum
- depression
- GABA
- glutamate
- glutamatergic receptors
- metabotropic glutamate receptors
- mitochondrial proteins
- molecular biology
- neurodegeneration
- neurotrophic factors
- nigro-striatal dopaminergic system
- Parkinson's disease
- proteasome
- psychopharmacology
- rat
- striatum
- thalamus
- tremor