Department of Neuro- and Psychopharmacology



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  • “Control of Motor Function by Adenosine A2A Receptors in Parkinson’s and Huntington’s Disease”

    chapter in the book:

    Pinna A., Wardas J., Domenici M. R., Popoli P., Cossu G. and Morelli M. “Control of Motor Function by Adenosine A2A Receptors in Parkinson’s and Huntington’s Disease” In: Blum D, Lopes LV, eds., "Adenosine Receptors in Neurodegenerative Diseases", San Diego: Academic Press, 2017: 188-214. 

  • Adenosine A2A receptors: Localization and Function.

    Simola N. and WARDAS J.: Adenosine A2A receptors: Localization and Function. (chapter 1)

    In: “The Adenosinergic System. A non-dopaminergic target in Parkinson’s disease” Eds. Morelli M, Simola N., Wardas J. Springer International Publishing Switzerland, 2015, pp. 1-25; Current Topics in Neurotoxicity, vol. 10 (Series Eds. Kostrzewa R., Archer T.).

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  • Motor thalamic nuclei as a potential therapeutic target for adenosine in parkinsonian and essential tremor; behavioural, neurochemical and molecular studies in rats, PhD Jadwiga Wardas
    1.    Research project objectives/Research hypothesis Essential (ET) and parkinsonian (PD) tremors are relatively frequent neurological disorders in humans. Since mechanisms underlying  these tremors are only poorly understood, current pharmacological therapies of these disturbances are highly insufficient. Therefore, there is an urgent need to search for these mechanisms and find out drugs which would be effective at the clinic.The ventral motor thalamus seems to be a brain structure crucial to relay and integrate impulses related to both PD tremor and ET. This region receives glutamatergic inputs from the cerebellum and GABAergic projections from the basal ganglia and therefore seems to be important for convergence of the cerebellar and basal ganglia informations.  The present project is devoted to examine whether adenosine and its receptors may be a target for future pharmacotherapy of ET and/or PD tremor. Since adenosine receptors (A1 and A2A) are present in neuronal networks of the ventral thalamic nuclei, the project is focused at examination of a modulatory role of adenosine receptor ligands on ET and PD tremor in animal models and a contribution of the cerebello-thalamic vs basal ganglia-thalamic circuits in these phenomena.  
  • , PhD Katarzyna Kuter
    “MOBILNOSC PLUS” scholarship sponsored by Polish Ministry of Science and Higher Education.
    Title: „Protective role of astrocytes in the process of neurodegeneration of dopaminergic cells and during functional compensation of this process. Analysis of function and architecture of mitochondrial oxphos complexes and supercomplexes in animal models of early Morbus Parkinson.”
    Performed during three 6 month visits at Technische Universität Darmstadt, Darmstadt, Germany in group of Prof. Norbert A. Dencher.
  • NCN grant, OPUS 3, PhD Katarzyna Kuter
    OPUS 3 grant nr 2012/05/B/NZ4/02599 financed by National Science Centre (NCN).
    Title: „The role of astrocytes and cellular metabolism in functional compensation of degeneration of dopaminergic system in threats brain. Analysis of expression of AMPK and energy sensing proteins in aspect of Parkinson's disease.”
    Performed in the Institute of Pharmacology, Polish Academy of Sciences – project leader.
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