Modern technics in neuroscience research
The course contains the following modules:
Basics of Magnetic Resonance Imaging.
This module provides basic knowledge on principles of magnetic resonance techniques as applied to non-invasive imaging and spectroscopy in vivo, i.e. pulse methods of magnetic resonance observations, spatial encoding, explanation of k-space and image space, image reconstruction, sources of contrast in MR images.
Moreover, basic MR imaging methods based on gradient echo and spin echo and the MRI equipment are discussed.
Applications of magnetic resonance imaging (MRI) and localised spectroscopy (MRS) methods for structural and functional research of the nervous system.
The lecture covers applications of the following advanced MRI/MRS methods for CNS research:
- Morphological 2D and 3D imaging with different endogenous and exogenous contrast mechanisms (T2, T1, proton density, external contrasts),
- Diffusion Weighted and Diffusion Tensor imaging (DWI, DTI) for tractography of brain,
- Perfusion Imaging and Angiography for assessment of vasculature in brain,
- Functional MR imaging (f-MRI) in Central Nervous System,
- Localised Spectroscopy (MRS) for assessment of brain metabolites,
- Molecular Imaging.
The presented topics are illustrated with data obtained using preclinical and clinical MRI equipment.
Other methods of bio-medical imaging.
The module covers principles and applications of the:
PET/SPECT (Positron emission tomography/Single photon emission computed tomography) and CT (Computed tomography) methods.
Basic experiments on imaging of the biological materials using 9.4 T preclinical MRI scanner.
The module, conducted in MRI Lab, covers practical demonstration of the use of preclinical MRI scanner for imaging of the biological material (e.g. plant, eggs) and projection of movie with animal experiments.