Katarzyna Kuter, PhD
Department of Neuro- and Psychopharmacology
The main interest of my research is recognition of mechanisms active in the preclinical stages of Parkinson’s Disease. There are both mechanisms leading to neuronal death as well as those compensating for deficits in brain dopaminergic system. Those opposite processes are active in the brain at the same time and mask early disease symptoms. Therefore, reliable diagnosis at the preclinical stages of Parkinson’s disease is very difficult and prevents from using neuroprotective and disease modifying strategies.Our studies in animal models focus on several aspects of brain functioning at the level of neural circuits, groups of cells, cellular organelles and particular proteins.
· Identification of mechanisms involved in compensation of dopaminergic neurons degeneration.
· Establishing the role of small, repeated oxidative stress in neurodegeneration - preconditioning.
· Protective role of glial cells and astrocyte – neuron cooperation in brain during compensation.
· The role of microglia polarisation in neurodegeneration and its compensation.
· Regulation of cellular energetics and substrate needs during different stages of degeneration and its compensation. Role of carbohydrates and fatty acids.
· Functioning of mitochondria and regulation of composition and activity of respiratory oxphos complexes and supercomplexes.
KEYWORDS: neurodegeneration, compensation, early Parkinson's disease, animal models, glia, dopaminergic system, energetic regulation, mitochondrial proteins
Increased energetic demand supported by mitochondrial electron transfer chain and astrocyte assistance is essential to maintain the compensatory ability of the dopaminergic neurons in an animal model of early Parkinson's disease.
Katarzyna Z Kuter, Łukasz Olech, Norbert A Dencher
Mitochondrion, S1567-7249(18)30095-3 10.1016/j.mito.2018.12.002
Astrocyte support is important for the compensatory potential of the nigrostriatal system neurons during early neurodegeneration.
Katarzyna Kuter, Łukasz Olech, Urszula Głowacka, Martyna Paleczna
Journal of neurochemistry, 10.1111/jnc.14605
Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA.
Katarzyna Kuter, Łukasz Olech, Urszula Głowacka
Molecular neurobiology, 10.1007/s12035-017-0529-z
Native DIGE proteomic analysis of mitochondria from substantia nigra and striatum during neuronal degeneration and its compensation in an animal model of early Parkinson's disease.
Katarzyna Kuter, Manuela Kratochwil, Sven-Hendric Marx, Sonja Hartwig, Stephan Lehr, Michiru D Sugawa, Norbert A Dencher
Archives of physiology and biochemistry,
Adaptation within mitochondrial oxidative phosphorylation supercomplexes and membrane viscosity during degeneration of dopaminergic neurons in an animal model of early Parkinson's disease.
Katarzyna Kuter, Manuela Kratochwil, Klemencja Berghauzen-Maciejewska, Urszula Głowacka, Michiru D Sugawa, Krystyna Ossowska, Norbert A Dencher
Biochimica et biophysica acta, S0925-4439(16)30025-4 10.1016/j.bbadis.2016.01.022
- 2018-08-03 - 2021-08-02
NCN grant, OPUS 14 [2018-08-03 - 2021-08-02]
Title: "How microglia-astrocyte interaction affects neuronal functioning
in the dopaminergic system. Analysis of protective potential of drugs changing the glial phenotype"
- 2013-09-02 - 2016-03-31
“MOBILNOSC PLUS” scholarship sponsored by Polish Ministry of Science and Higher Education.
Title: „Protective role of astrocytes in the process of neurodegeneration of dopaminergic cells and during functional compensation of this process. Analysis of function and architecture of mitochondrial oxphos complexes and supercomplexes in animal models of early Morbus Parkinson.”
Performed during three 6 month visits at Technische Universität Darmstadt, Darmstadt, Germany in group of Prof. Norbert A. Dencher.
NCN grant, OPUS 3 - 2013-02-14 - 2017-02-15
OPUS 3 grant nr 2012/05/B/NZ4/02599 financed by National Science Centre (NCN).
Title: „The role of astrocytes and cellular metabolism in functional compensation of degeneration of dopaminergic system in threats brain. Analysis of expression of AMPK and energy sensing proteins in aspect of Parkinson's disease.”
Performed in the Institute of Pharmacology, Polish Academy of Sciences – project leader.
Team Scientific Award of the 5th Medical Sciences PAS for a series of 3 publications "The role of astrocytes in mechanisms compensating for the degeneration of dopaminergic neurons and in the regulation of cellular energy of the black-striatal system in an animal model of early Parkinson's disease".
Award for publication woth high IF in 2018 granted by the Head of the Institute of Pharmacology
- dr Monika Marcinkowska, Katedra Chemii Farmaceutyczne Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie
- Prof. M. Schwab, Brain Research Institute, University of Zurich