Jolanta Konieczny, PhD
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Antiparkinsonian-like effects of CPL500036, a novel selective inhibitor of phosphodiesterase 10A, in the unilateral rat model of Parkinson's disease.
Tomasz Lenda, Krystyna Ossowska, Klemencja Berghauzen-Maciejewska, Mikołaj Matłoka, Jerzy Pieczykolan, Maciej Wieczorek, Jolanta Konieczny
European journal of pharmacology, S0014-2999(21)00614-2 10.1016/j.ejphar.2021.174460
PMID:34469756
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Inhibition of Excessive Glutamatergic Transmission in the Ventral Thalamic Nuclei by a Selective Adenosine A1 Receptor Agonist, 5'-Chloro-5'-Deoxy-(±)-ENBA Underlies its Tremorolytic Effect in the Harmaline-Induced Model of Essential Tremor.
Barbara Kosmowska, Krystyna Ossowska, Jolanta Konieczny, Tomasz Lenda, Klemencja Berghauzen-Maciejewska, Jadwiga Wardas
Neuroscience, S0306-4522(20)30003-8 10.1016/j.neuroscience.2019.12.045
PMID:31935489
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Interactions of the tricyclic antidepressant drug amitriptyline with L-DOPA in the striatum and substantia nigra of unilaterally 6-OHDA-lesioned rats. Relevance to motor dysfunction in Parkinson's disease.
Kinga Kamińska, Tomasz Lenda, Jolanta Konieczny, Jadwiga Wardas, Elżbieta Lorenc-Koci
Neurochemistry international, S0197-0186(18)30177-3 10.1016/j.neuint.2018.10.004
PMID:30290201
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Depressive-like neurochemical and behavioral markers of Parkinson's disease after 6-OHDA administered unilaterally to the rat medial forebrain bundle.
Kinga Kamińska, Tomasz Lenda, Jolanta Konieczny, Anna Czarnecka, Elżbieta Lorenc-Koci
Pharmacological reports : PR, S1734-1140(17)30231-1 10.1016/j.pharep.2017.05.016
PMID:28843848
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The significance of rotational behavior and sensitivity of striatal dopamine receptors in hemiparkinsonian rats: A comparative study of lactacystin and 6-OHDA.
Jolanta Konieczny, Anna Czarnecka, Tomasz Lenda, Kinga Kamińska, Lucyna Antkiewicz-Michaluk
Neuroscience, S0306-4522(16)30611-X 10.1016/j.neuroscience.2016.10.070
PMID:27826109
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Early increase in dopamine release in the ipsilateral striatum after unilateral intranigral administration of lactacystin produces spontaneous contralateral rotations in rats.
J Konieczny, T Lenda, A Czarnecka
Neuroscience, 10.1016/j.neuroscience.2016.02.072 S0306-4522(16)00222-0
PMID:26964686
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The preferential nNOS inhibitor 7-nitroindazole and the non-selective one N(G)-nitro-L-arginine methyl ester administered alone or jointly with L-DOPA differentially affect motor behavior and monoamine metabolism in sham-operated and 6-OHDA-lesioned rats.
Anna Czarnecka, Jolanta Konieczny, Tomasz Lenda, Elżbieta Lorenc-Koci
Brain research, 10.1016/j.brainres.2015.08.006 S0006-8993(15)00610-1
PMID:26319690
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Decreased behavioral response to intranigrally administered GABAA agonist muscimol in the lactacystin model of Parkinson's disease may result from partial lesion of nigral non-dopamine neurons: comparison to the classical neurotoxin 6-OHDA.
Jolanta Konieczny, Anna Czarnecka, Kinga Kamińska, Tomasz Lenda, Przemysław Nowak
Behavioural brain research, 10.1016/j.bbr.2015.01.043 S0166-4328(15)00060-1
PMID:25655509
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Contribution of the mGluR7 receptor to antiparkinsonian-like effects in rats: a behavioral study with the selective agonist AMN082.
Jolanta Konieczny, Tomasz Lenda
Pharmacological reports : PR,
PMID:24399715
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Lack of neuroprotective effect of celastrol under conditions of proteasome inhibition by lactacystin in in vitro and in vivo studies: implications for Parkinson's disease.
Jolanta Konieczny, Danuta Jantas, Tomasz Lenda, Helena Domin, Anna Czarnecka, Katarzyna Kuter, Maria Śmiałowska, Władysław Lasoń, Elżbieta Lorenc-Koci
Neurotoxicity research, 10.1007/s12640-014-9477-9
PMID:24842651
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Chronic L-DOPA treatment attenuates behavioral and biochemical deficits induced by unilateral lactacystin administration into the rat substantia nigra.
Jolanta Konieczny, Anna Czarnecka, Tomasz Lenda, Kinga Kamińska, Elżbieta Lorenc-Koci
Behavioural brain research, 10.1016/j.bbr.2013.12.019 S0166-4328(13)00762-6
PMID:24361083
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Alterations in the expression of nNOS in the substantia nigra and subthalamic nucleus of 6-OHDA-lesioned rats: the effects of chronic treatment with l-DOPA and the nitric oxide donor, molsidomine.
Anna Czarnecka, Tomasz Lenda, Helena Domin, Jolanta Konieczny, Maria Smiałowska, Elżbieta Lorenc-Koci
Brain research, 10.1016/j.brainres.2013.10.011 S0006-8993(13)01376-0
PMID:24129225
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Molsidomine, a nitric oxide donor, modulates rotational behavior and monoamine metabolism in 6-OHDA lesioned rats treated chronically with L-DOPA.
Elżbieta Lorenc-Koci, Anna Czarnecka, Tomasz Lenda, Kinga Kamińska, Jolanta Konieczny
Neurochemistry international, 10.1016/j.neuint.2013.09.021 S0197-0186(13)00249-0
PMID:24090640
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The extent of neurodegeneration and neuroprotection in two chemical in vitro models related to Parkinson's disease is critically dependent on cell culture conditions.
D Jantas, A Roman, J Kuśmierczyk, E Lorenc-Koci, J Konieczny, T Lenda, W Lasoń
Neurotoxicity research, 10.1007/s12640-012-9374-z
PMID:23307753
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Different effects of intranigral and intrastriatal administration of the proteasome inhibitor lactacystin on typical neurochemical and histological markers of Parkinson's disease in rats.
Elżbieta Lorenc-Koci, Tomasz Lenda, Lucyna Antkiewicz-Michaluk, Jadwiga Wardas, Helena Domin, Maria Smiałowska, Jolanta Konieczny
Neurochemistry international, 10.1016/j.neuint.2011.03.013
PMID:21419185
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N-oleoyl-dopamine decreases muscle rigidity induced by reserpine in rats.
J Konieczny, E Przegalinski, M Pokorski
International journal of immunopathology and pharmacology,
PMID:19309549
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Toxic influence of subchronic paraquat administration on dopaminergic neurons in rats.
Katarzyna Kuter, Maria Smiałowska, Joanna Wierońska, Barbara Zieba, Jadwiga Wardas, Małgorzata Pietraszek, Przemysław Nowak, Izabela Biedka, Wojciech Roczniak, Jolanta Konieczny, Stanisław Wolfarth, Krystyna Ossowska
Brain research,
PMID:17493592
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The influence of group III metabotropic glutamate receptor stimulation by (1S,3R,4S)-1-aminocyclo-pentane-1,3,4-tricarboxylic acid on the parkinsonian-like akinesia and striatal proenkephalin and prodynorphin mRNA expression in rats.
J Konieczny, J Wardas, K Kuter, A Pilc, K Ossowska
Neuroscience,
PMID:17224239
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An influence of ligands of metabotropic glutamate receptor subtypes on parkinsonian-like symptoms and the striatopallidal pathway in rats.
K Ossowska, J Konieczny, J Wardas, M Pietraszek, K Kuter, S Wolfarth, A Pilc
Amino acids,
PMID:16699817
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MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian-like effects in rats.
K Ossowska, J Konieczny, S Wolfarth, A Pilc
Neuropharmacology,
PMID:15919101
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The role of striatal metabotropic glutamate receptors in Parkinson's disease.
K Ossowska, J Konieczny, J Wardas, K Gołembiowska, S Wolfarth, A Pilc
Amino acids,
PMID:12373537
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The role of striatal metabotropic glutamate receptors in degeneration of dopamine neurons: review article.
K Gołembiowska, J Konieczny, K Ossowska, S Wolfarth
Amino acids,
PMID:12373538
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Neuroprotective action of MPEP, a selective mGluR5 antagonist, in methamphetamine-induced dopaminergic neurotoxicity is associated with a decrease in dopamine outflow and inhibition of hyperthermia in rats.
K Gołembiowska, J Konieczny, S Wolfarth, K Ossowska
Neuropharmacology,
PMID:12907309
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The striopallidal pathway is involved in antiparkinsonian-like effects of the blockade of group I metabotropic glutamate receptors in rats.
Krystyna Ossowska, Jadwiga Wardas, Małgorzata Pietraszek, Jolanta Konieczny, Stanisław Wolfarth
Neuroscience letters,
PMID:12727308
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Influence of CGS 21680, a selective adenosine A(2A) agonist, on the phencyclidine-induced sensorimotor gating deficit and motor behaviour in rats.
Jadwiga Wardas, Jolanta Konieczny, Małgorzata Pietraszek
Psychopharmacology,
PMID:12684736
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The striatum as a target for anti-rigor effects of an antagonist of mGluR1, but not an agonist of group II metabotropic glutamate receptors.
Krystyna Ossowska, Jolanta Konieczny, Andrzej Pilc, Stanislaw Wolfarth
Brain research,
PMID:12231232
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Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats.
K Ossowska, J Konieczny, S Wolfarth, J Wierońska, A Pilc
Neuropharmacology,
PMID:11543761
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SCH 58261, an A(2A) adenosine receptor antagonist, counteracts parkinsonian-like muscle rigidity in rats.
J Wardas, J Konieczny, E Lorenc-Koci
Synapse (New York, N.Y.),
PMID:11400182
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The role of metabotropic glutamate receptor (mGluR) ligands in parkinsonian muscle rigidity.
S Wolfarth, J Konieczny, E Lorenc-Koci, K Ossowska, A Pilc
Amino acids,
PMID:11026478
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The role of striatal adenosine A2A receptors in regulation of the muscle tone in rats.
J Wardas, J Konieczny, E Lorenc-Koci
Neuroscience letters,
PMID:10624796
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L-701,324, a selective antagonist at the glycine site of the NMDA receptor, counteracts haloperidol-induced muscle rigidity in rats.
J Konieczny, K Ossowska, G Schulze, H Coper, S Wolfarth
Psychopharmacology,
PMID:10353425
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Contribution of the glycine site of NMDA receptors in rostral and intermediate-caudal parts of the striatum to the regulation of muscle tone in rats.
E Lorenc-Koci, J Konieczny, S Wolfarth
Brain research,
PMID:9630698
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LY354740, a group II metabotropic glutamate receptor agonist with potential antiparkinsonian properties in rats.
J Konieczny, K Ossowska, S Wolfarth, A Pilc
Naunyn-Schmiedeberg's archives of pharmacology,
PMID:9826074
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The role of striatal glutamate receptors in models of Parkinson's disease.
K Ossowska, E Lorenc-Koci, J Konieczny, S Wolfarth
Amino acids,
PMID:9871435
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Muscle rigidity induced by fluphenazine in rats is antagonized by L-DOPA, an antiparkinsonian drug.
K Ossowska, J Konieczny, E Lorenc-Koci, G Schulze, H Coper, S Wolfarth
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
PMID:9670114
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NMDA receptors in the rostral and intermediate-caudal striatum play an opposite role in regulation of the muscle tone in rats.
K Ossowska, J Konieczny
Polish journal of pharmacology,
PMID:9112661
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Influence of 6-hydroxydopamine lesion of the dopaminergic nigrostriatal pathway on the muscle tone and electromyographic activity measured during passive movements.
S Wolfarth, J Konieczny, M Smiałowska, G Schulze, K Ossowska
Neuroscience,
PMID:8895867
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The role of reflex activity in the regulation of muscle tone in rats.
K Ossowska, E Lorenc-Koci, G Schulze, J Konieczny, S Wolfarth, M Bojarski, H Coper
Experimental physiology,
PMID:8845136
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Involvement of the nucleus accumbens in the myorelaxant effect of baclofen in rats.
E Lorenc-Koci, K Ossowska, J Wardas, J Konieczny, S Wolfarth
Neuroscience letters,
PMID:8041487
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