Professor Małgorzata Kajta, PhD
Position
Professor
Professor
Department
Department of Drug Addiction Pharmacology
Department of Drug Addiction Pharmacology
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Prenatal Exposure to Triclocarban Impairs ESR1 Signaling and Disrupts Epigenetic Status in Sex-Specific Ways as Well as Dysregulates the Expression of Neurogenesis- and Neurotransmitter-Related Genes in the Postnatal Mouse Brain.
Agnieszka Wnuk, Joanna Rzemieniec, Karolina Przepiórska, Bernadeta Angelika Pietrzak, Marzena Maćkowiak, Małgorzata Kajta
International journal of molecular sciences, 13121 10.3390/ijms222313121
PMID:34884933 -
Posttreatment Strategy Against Hypoxia and Ischemia Based on Selective Targeting of Nonnuclear Estrogen Receptors with PaPE-1.
A Wnuk, K Przepiórska, B A Pietrzak, M Kajta
Neurotoxicity research, 10.1007/s12640-021-00441-y
PMID:34797527 -
Is the commonly used UV filter benzophenone-3 a risk factor for the nervous system?
Agnieszka Wnuk, Małgorzata Kajta
Acta biochimica Polonica, 10.18388/abp.2020_5741
PMID:34351731 -
Post-Treatment with Amorfrutin B Evokes PPARγ-Mediated Neuroprotection against Hypoxia and Ischemia.
Agnieszka Wnuk, Karolina Przepiórska, Bernadeta A Pietrzak, Małgorzata Kajta
Biomedicines, 854 10.3390/biomedicines9080854
PMID:34440058 -
Neuroprotective effect of 3,3'-Diindolylmethane against perinatal asphyxia involves inhibition of the AhR and NMDA signaling and hypermethylation of specific genes.
J Rzemieniec, E Bratek, A Wnuk, K Przepiórska, E Salińska, M Kajta
Apoptosis : an international journal on programmed cell death, 10.1007/s10495-020-01631-3
PMID:32816128
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In search of new therapeutic strategies for the treatment of hypoxia-ischemia-induced brain damages. An article in Polish.
NAUKA, 2016, 3:55-73. Kajta M, Rzemieniec J, Rużyłło W.
- How hormonally active environmental contaminants affect the brain? An article in Polish. Wszechświat, 2012, 113:10-13. Kajta M.
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Molecular mechanisms of estrogen action in the central nervous system. An article in Polish.
Chapter in the script: Cellular signaling pathways. Edited by I. Nalepa. XXI Zimowa Szkoła Instytutu Farmakologii PAN. Mogilany, 2004,
61-69. Kajta M.
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Neuronal cell cultures. An article in Polish.
Chapter XVII in the book: Cell and Tissue Cultures. Edited by S. Stokłosowa. PWN, Warszawa, 2004, 277-290. Kajta M.
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Selective activation of non-nuclear Estrogen Receptor signaling with PaPE-1 as a novel therapeutic approach for sporadic Alzheimer’s Disease - 2021-07-27 - 2024-07-26
NCN OPUS Grant; 2020/39/B/NZ7/00974; 2021-2024. Ongoing.
Principal Investigator of the grant: Małgorzata Kajta -
Searching for effective strategies to protect neuronal cells against hypoxia and ischemia: Identification of neuroprotective mechanisms of the new ligands of AhR and PPARg in experimental models of stroke - 2019-06-28 - 2022-06-27
NCN OPUS Grant; 2018/31/B/NZ7/01815; 2019-2022. Ongoing.Principal Investigator of the grant: Małgorzata Kajta
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Neurodevelopmental pathomechanisms of triclocarban-, and Dichlorodiphenyldichloroethylene (DDE)-induced effects: the roles of apoptosis and autophagy as well as the receptor signaling for estrogens, aryl hydrocarbons and androstane. - 2016-06-20 - 2019-06-19
NCN OPUS Grant; 2015/19/B/NZ7/02449; 2016-2019.
Principal Investigator of the grant: Małgorzata Kajta
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Impact of endocrine-disrupting compound - 4-para-nonylphenol – on toxic effects mediated by xenobiotic receptors PXR and CAR during neural development in vitro and in vivo. - 2011-12-15 - 2014-12-14
NCN PRELUDIUM Grant; 2011/01/N/NZ4/04950; 2011-2014. Principal Investigator of the grant: Ewa Litwa The scientific supervisor of the grant: Małgorzata Kajta
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Effect of selective estrogen receptor modulators and aromatic hydrocarbon receptors on hypoxia / ischemia-induced apoptosis of neuronal cells - 2011-11-21 - 2014-11-20
NCN PRELUDIUM Grant; 2011/01/N/NZ3/04786; 2011-2014Principal Investigator of the grant: Joanna RzemieniecThe Scientific Supervisor of the grant: Małgorzata Kajta
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Neuroprotective capacities of phytoestrogens in neurodevelopmental models of hypoxia and excitotoxicity. - 2010-03-03 - 2012-03-02
MNiSW Grant; N N401 572138; 2010-2013. Principal Investigator of the grant: Małgorzata Kajta
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Task 2.3: The role of estrogen receptor, aryl hydrocarbon receptor, and retinoid receptor signaling pathways in pathomechanisms of depression. - 2010-03-01 - 2014-12-31
The project Depression-Mechanisms-Therapies (DeMeTer) co-funded by the EU’s European Regional Development Fund, as part of the ‘Innovative Economy: 2007-2013 National Cohesion Strategy’ Operational Programme. POIG.01.01.02-12-004/09; 2010-2014. Principal Investigator of the task 2.3: Małgorzata Kajta
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A role of dioxins and aryl hydrocarbon receptor in apoptosis of neuronal cells: mechanisms and protective strategies. - 2006-05-05 - 2009-05-04
MEiN Grant; 2P05A 123 30; 2006 2009. Principal Invetigator of the grant: Małgorzata Kajta
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A Team Award of the V Faculty of Medical Sciences of the Polish Academy of Sciences for a series of publications.
2018-11-22 -
J. J. Supniewski Foundation award for scientific achievements.
2004-02-25
National
- Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN; Prof. dr hab. Wiesław Łasocha
- Instytut Medycyny Doświadczalnej i Klinicznej im M. Mossakowskiego PAN, Zakład Neurochemii; Dr hab. Elżbieta Salińska
- Uniwersytet Przyrodniczy w Poznaniu, Instytut Zoologii, Pracownia Neurobiologii; Dr hab. Joanna Śliwowska
- Uniwersytet Rolniczy im. H. Kołłątaja w Krakowie, Katedra Biotechnologii Zwierząt; Prof. dr hab. Anna K. Wójtowicz
- Wyższa Szkoła Informatyki i Zarządzania w Rzeszowie, Katedra Zdrowia Publicznego, Dietetyki i Chorób Cywilizacyjnych; Dr Konrad Szychowski
International
- RWTH Aachen University, Institute of Neuroanatomy, Germany; Prof. Cordian Beyer
- University of Haifa, Department of Psychology, Israel; Prof. Inna Gaisler-Salomon
interests
techniques
keywords
- 3,3’-diindolylmethane
- ADHD
- Alzheimer disease
- apoptosis
- aryl hydrocarbon receptor – AhR
- asphyxia
- autophagy
- Bazedoxifene
- Benzophenone-3
- confocal microscopy
- Daidzein
- DDE
- DDT
- depression
- DNA methylation
- epigenetics
- estrogen receptors
- estrogen receptors – ERs
- excitotoxicity
- fluorescent microscopy
- G-protein coupled receptors
- gene expression
- Genistein
- hormones
- hypoxia
- hypoxia
- ischemia
- ischemia
- microarrays
- molecular biology
- necrosis
- neurodegeneration
- neurogenesis
- neuroprotection
- neurotoxicity
- peroxisome proliferator-activated receptors – PPARs
- pesticides
- pharmacotherapy
- phytoestrogens
- primary neuronal cell cultures
- Raloxifene
- retinoid X receptors – RXRs
- selective aryl hydrocarbon receptor modulators – SAhRMs
- selective estrogen receptor modulators – SERMs
- stem cells
- stroke
- triclocarban
- xenobiotic receptors