Danuta Jantas, PhD

Position
Adjunct

Department
Department of Brain Biochemistry

jantas@if-pan.krakow.pl

+48 12 3343721

room: 2.1

My research interests are mainly focused on cellular models of neurodegeneration and neuroprotection. In addition to searching for intracellular mechanisms of action of clinically used drugs, I am also interested in investigating new synthetic or natural compounds with neuroprotective or anticancer activities.

Vitamin D3 and Ischemic Stroke: A Narrative Review. Władysław Lasoń, Danuta Jantas, Monika Leśkiewicz, Magdalena Regulska, Agnieszka Basta-Kaim
Antioxidants (Basel, Switzerland), 2120 10.3390/antiox11112120
PMID:36358492
The Impact of the Combined Administration of 1MeTIQ and MK-801 on Cell Viability, Oxidative Stress Markers, and Glutamate Release in the Rat Hippocampus. Agnieszka Wąsik, Magdalena Białoń, Danuta Jantas, Marcelina Żarnowska
Neurotoxicity research, 10.1007/s12640-021-00428-9
PMID:34665405
undefined Danuta Jantas, Janusz Malarz, Thanh Nguyen Le, Anna Stojakowska
International journal of molecular sciences, 10363 10.3390/ijms221910363
PMID:34638702
Preclinical Evidence for the Interplay between Oxidative Stress and RIP1-Dependent Cell Death in Neurodegeneration: State of the Art and Possible Therapeutic Implications. Danuta Jantas, Władysław Lasoń
Antioxidants (Basel, Switzerland), 1518 10.3390/antiox10101518
PMID:34679652
Neuroprotective Effects of Methyl Caffeate against Hydrogen Peroxide-Induced Cell Damage: Involvement of Caspase 3 and Cathepsin D Inhibition. Danuta Jantas, Jakub Chwastek, Janusz Malarz, Anna Stojakowska, Władysław Lasoń
Biomolecules, E1530 10.3390/biom10111530
PMID:33182454
Neuroprotective Effects of Necrostatin-1 Against Oxidative Stress-Induced Cell Damage: an Involvement of Cathepsin D Inhibition. Danuta Jantas, Jakub Chwastek, Beata Grygier, Władysław Lasoń
Neurotoxicity research, 10.1007/s12640-020-00164-6
PMID:31960265
New evidences for a role of mGluR7 in astrocyte survival: Possible implications for neuroprotection. Danuta Jantas, Tomasz Lech, Sławomir Gołda, Andrzej Pilc, Władysław Lasoń
Neuropharmacology, S0028-3908(18)30585-9 10.1016/j.neuropharm.2018.08.035
PMID:30170084
An endogenous and ectopic expression of metabotropic glutamate receptor 8 (mGluR8) inhibits proliferation and increases chemosensitivity of human neuroblastoma and glioma cells. Danuta Jantas, Beata Grygier, Sławomir Gołda, Jakub Chwastek, Justyna Zatorska, Magdalena Tertil
Cancer letters, S0304-3835(18)30400-2 10.1016/j.canlet.2018.06.004
PMID:29885518
Allosteric and Orthosteric Activators of mGluR8 differentially affect the Chemotherapeutic-induced Human Neuroblastoma SH-SY5Y Cell Damage: The Impact of Cell Differentiation State. Danuta Jantas, Beata Grygier, Justyna Zatorska, Władysław Lasoń
Basic & clinical pharmacology & toxicology, 10.1111/bcpt.13041
PMID:29753314
Transcriptional signatures of steroid hormones in the striatal neurons and astrocytes. Marcin Piechota, Michał Korostynski, Slawomir Golda, Joanna Ficek, Danuta Jantas, Ziolkowska Barbara, Ryszard Przewlocki
BMC neuroscience, 10.1186/s12868-017-0352-5
PMID:28381250
The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D. Jakub Chwastek, Danuta Jantas, Władysław Lasoń
The international journal of biochemistry & cell biology, S1357-2725(17)30067-5 10.1016/j.biocel.2017.03.015
PMID:28341201
Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats. Helena Domin, Łukasz Przykaza, Danuta Jantas, Ewa Kozniewska, Paweł M Boguszewski, Maria Śmiałowska
Neuroscience, S0306-4522(16)30740-0 10.1016/j.neuroscience.2016.12.040
PMID:28057538
The neuroprotective effects of orthosteric agonists of group II and III mGluRs in primary neuronal cell cultures are dependent on developmental stage. D Jantas, A Gręda, S Gołda, M Korostyński, W Lasoń
Neuropharmacology, S0028-3908(16)30378-1 10.1016/j.neuropharm.2016.09.003
PMID:27600687
Encapsulation of curcumin in polyelectrolyte nanocapsules and their neuroprotective activity. Krzysztof Szczepanowicz, Danuta Jantas, Marek Piotrowski, Jakub Staroń, Monika Leśkiewicz, Magdalena Regulska, Władysław Lasoń, Piotr Warszyński
Nanotechnology, 10.1088/0957-4484/27/35/355101
PMID:27454207
Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: in vitro and in vivo studies. Helena Domin, Łukasz Przykaza, Danuta Jantas, Ewa Kozniewska, Paweł M Boguszewski, Maria Śmiałowska
Neuropharmacology, S0028-3908(15)30189-1 10.1016/j.neuropharm.2015.11.025
PMID:26647070
Regulation of alternative gene transcription in the striatum in response to antidepressant drugs. Marcin Piechota, Slawomir Golda, Joanna Ficek, Danuta Jantas, Ryszard Przewlocki, Michal Korostynski
Neuropharmacology, 10.1016/j.neuropharm.2015.08.006 S0028-3908(15)30052-6
PMID:26254862
An Involvement of PI3-K/Akt Activation and Inhibition of AIF Translocation in Neuroprotective Effects of Undecylenic Acid (UDA) Against Pro-Apoptotic Factors-Induced Cell Death in Human Neuroblastoma SH-SY5Y Cells. Danuta Jantas, Marek Piotrowski, Wladyslaw Lason
Journal of cellular biochemistry, 10.1002/jcb.25236
PMID:26012840
The dissection of stress-induced profile of gene expression between astrocytes and neurons. Michal Korostynski, Marcin Piechota, Klaudia Szklarczyk, Slawomir Golda, Joanna Ficek, Danuta Jantas, Ryszard Przewlocki
Psychoneuroendocrinology, 10.1016/j.psyneuen.2015.07.555 S0306-4530(15)00789-1
PMID:26383439
Neuroprotective effects of the allosteric agonist of metabotropic glutamate receptor 7 AMN082 on oxygen-glucose deprivation- and kainate-induced neuronal cell death. Helena Domin, Danuta Jantas, Maria Śmiałowska
Neurochemistry international, 10.1016/j.neuint.2014.12.010 S0197-0186(15)00002-9
PMID:25576184
Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation. D Jantas, A Greda, M Leskiewicz, B Grygier, A Pilc, W Lason
Neurochemistry international, 10.1016/j.neuint.2014.12.011 S0197-0186(15)00003-0
PMID:25661514
[The role of ATM kinase in neurodegeneration]. Jakub Chwastek, Danuta Jantas, Władysław Lasoń
Postepy biochemii,
PMID:26263761
Polyelectrolyte-coated nanocapsules containing undecylenic acid: Synthesis, biocompatibility and neuroprotective properties. Marek Piotrowski, Danuta Jantas, Krzysztof Szczepanowicz, Sylwia Łukasiewicz, Władysław Lasoń, Piotr Warszyński
Colloids and surfaces. B, Biointerfaces, 10.1016/j.colsurfb.2015.07.029 S0927-7765(15)30064-3
PMID:26231861
Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Helena Domin, Krystyna Gołembiowska, Danuta Jantas, Katarzyna Kamińska, Barbara Zięba, Maria Smiałowska
Neurotoxicity research, 10.1007/s12640-013-9455-7
PMID:24402869
Neuroprotective effects of metabotropic glutamate receptor group II and III activators against MPP(+)-induced cell death in human neuroblastoma SH-SY5Y cells: the impact of cell differentiation state. D Jantas, A Greda, S Golda, M Korostynski, B Grygier, A Roman, A Pilc, W Lason
Neuropharmacology, 10.1016/j.neuropharm.2014.03.019 S0028-3908(14)00124-5
PMID:24713472
Lack of neuroprotective effect of celastrol under conditions of proteasome inhibition by lactacystin in in vitro and in vivo studies: implications for Parkinson's disease. Jolanta Konieczny, Danuta Jantas, Tomasz Lenda, Helena Domin, Anna Czarnecka, Katarzyna Kuter, Maria Śmiałowska, Władysław Lasoń, Elżbieta Lorenc-Koci
Neurotoxicity research, 10.1007/s12640-014-9477-9
PMID:24842651
The predominant protective effect of tianeptine over other antidepressants in models of neuronal apoptosis: the effect blocked by inhibitors of MAPK/ERK1/2 and PI3-K/Akt pathways. D Jantas, S Krawczyk, W Lason
Neurotoxicity research, 10.1007/s12640-013-9430-3
PMID:24105645
Antidepressants attenuate the dexamethasone-induced decrease in viability and proliferation of human neuroblastoma SH-SY5Y cells: a involvement of extracellular regulated kinase (ERK1/2). M Leskiewicz, D Jantas, M Regulska, J Kaczanowska, A Basta-Kaim, B Budziszewska, M Kubera, W Lason
Neurochemistry international, 10.1016/j.neuint.2013.07.007 S0197-0186(13)00202-7
PMID:23906970
The extent of neurodegeneration and neuroprotection in two chemical in vitro models related to Parkinson's disease is critically dependent on cell culture conditions. D Jantas, A Roman, J Kuśmierczyk, E Lorenc-Koci, J Konieczny, T Lenda, W Lasoń
Neurotoxicity research, 10.1007/s12640-012-9374-z
PMID:23307753
Neuroprotective effects of MAPK/ERK1/2 and calpain inhibitors on lactacystin-induced cell damage in primary cortical neurons. D Jantas, E Lorenc-Koci, M Kubera, W Lason
Neurotoxicology, 10.1016/j.neuro.2011.05.013
PMID:21683092
Stimulatory effect of antidepressant drug pretreatment on progression of B16F10 melanoma in high-active male and female C57BL/6J mice. Marta Kubera, Beata Grygier, Danuta Wrona, Zofia Rogóż, Adam Roman, Agnieszka Basta-Kaim, Bogusława Budziszewska, Monika Leskiewicz, Danuta Jantas, Wojciech Nowak, Michael Maes, Wladyslaw Lason
Journal of neuroimmunology, 10.1016/j.jneuroim.2011.09.006
PMID:22030244
[Therapeutic potential of thyreoliberin (TRH) and its analogues as antiepileptic and neuroprotective drugs]. Danuta Jantas
Przegla̧d lekarski,
PMID:21442973
Protective effects of TRH and its analogues against various cytotoxic agents in retinoic acid (RA)-differentiated human neuroblastoma SH-SY5Y cells. L Jaworska-Feil, D Jantas, M Leskiewicz, B Budziszewska, M Kubera, A Basta-Kaim, A W Lipkowski, W Lason
Neuropeptides, 10.1016/j.npep.2010.08.004
PMID:20869113
The decrease in JNK- and p38-MAP kinase activity is accompanied by the enhancement of PP2A phosphate level in the brain of prenatally stressed rats. B Budziszewska, M Szymanska, M Leskiewicz, A Basta-Kaim, L Jaworska-Feil, M Kubera, D Jantas, W Lason
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
PMID:20436222
Anti-apoptotic effect of memantine against staurosporine- and low-potassium-induced cell death in cerebellar granule cells: a development-dependent effect. Danuta Jantas, Władysław Lasoń
Pharmacological reports : PR,
PMID:19904005
Effects of TRH and its analogues on primary cortical neuronal cell damage induced by various excitotoxic, necrotic and apoptotic agents. D Jantas, L Jaworska-Feil, A W Lipkowski, W Lason
Neuropeptides, 10.1016/j.npep.2009.07.002
PMID:19666192
Different mechanisms of NMDA-mediated protection against neuronal apoptosis: a stimuli-dependent effect. Danuta Jantas, Wladyslaw Lason
Neurochemical research, 10.1007/s11064-009-9991-y
PMID:19462233
An involvement of BDNF and PI3-K/Akt in the anti-apoptotic effect of memantine on staurosporine-evoked cell death in primary cortical neurons. D Jantas, M Szymanska, B Budziszewska, W Lason
Apoptosis : an international journal on programmed cell death, 10.1007/s10495-009-0370-6
PMID:19521778
Protective effect of memantine against Doxorubicin toxicity in primary neuronal cell cultures: influence a development stage. D Jantas, W Lason
Neurotoxicity research, 10.1007/s12640-009-9002-8
PMID:19384585
Neuroprotection by co-treatment and post-treating with calcitriol following the ischemic and excitotoxic insult in vivo and in vitro. Małgorzata Kajta, Dorota Makarewicz, Elzbieta Ziemińska, Danuta Jantas, Helena Domin, Władysław Lasoń, Andrzej Kutner, Jerzy W Łazarewicz
Neurochemistry international, 10.1016/j.neuint.2009.03.010
PMID:19576513
Neurosteroids enhance the viability of staurosporine and doxorubicin treated differentiated human neuroblastoma SH-SY5Y cells. Monika Leśkiewicz, Magdalena Regulska, Bogusława Budziszewska, Danuta Jantas, Lucylla Jaworska-Feil, Agnieszka Basta-Kaim, Marta Kubera, Władysław Lasoń
Pharmacological reports : PR,
PMID:19066415
Excitatory neurosteroids attenuate apoptotic and excitotoxic cell death in primary cortical neurons. M Leskiewicz, D Jantas, B Budziszewska, W Lason
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
PMID:18953090
Effects of neurosteroids on hydrogen peroxide- and staurosporine-induced damage of human neuroblastoma SH-SY5Y cells. M Leskiewicz, M Regulska, B Budziszewska, D Jantas, L Jaworska-Feil, A Basta-Kaim, M Kubera, G Jagla, W Nowak, W Lason
Journal of neuroscience research, 10.1002/jnr.21591
PMID:18189315
Inhibitory effects of 1,25-dihydroxyvitamin D3 and its low-calcemic analogues on staurosporine-induced apoptosis. Magdalena Regulska, Monika Leśkiewicz, Bogusława Budziszewska, Andrzej Kutner, Danuta Jantas, Agnieszka Basta-Kaim, Marta Kubera, Lucylla Jaworska-Feil, Władysław Lasoń
Pharmacological reports : PR,
PMID:17901567
The attenuating effect of memantine on staurosporine-, salsolinol- and doxorubicin-induced apoptosis in human neuroblastoma SH-SY5Y cells. D Jantas, M Pytel, J W Mozrzymas, M Leskiewicz, M Regulska, L Antkiewicz-Michaluk, W Lason
Neurochemistry international,
PMID:17996985
New targets for putative neuroprotective agents. Danuta Jantas-Skotniczna, Małgorzata Kajta, Władysław Lasoń
Acta poloniae pharmaceutica,
PMID:17357585
Memantine attenuates staurosporine-induced activation of caspase-3 and LDH release in mouse primary neuronal cultures. Danuta Jantas-Skotniczna, Małgorzata Kajta, Władysław Lasoń
Brain research,
PMID:16386235
Exploring CVD Method for Synthesizing Carbon-Carbon Composites as Materials to Contact with Nerve Tissue. Aneta Fraczek-Szczypta, Natalia Kondracka, Marcel Zambrzycki, Maciej Gubernat, Pawel Czaja, Miroslawa Pawlyta, Piotr Jelen, Ryszard Wielowski, Danuta Jantas
,
PMID:37754857
Neuroprotective effects of polyacrylic acid (PAA) conjugated cerium oxide against hydrogen peroxide- and 6-OHDA-induced SH-SY5Y cell damage. Rugmani Meenambal, Tomasz Kruk, Jacek Gurgul, Piotr Warszyński, Danuta Jantas
,
PMID:37898622
undefined Rugmani Meenambal, Tomasz Kruk, Klaudia Jakubowska, Jacek Gurgul, Krzysztof Szczepanowicz, Marta Szczęch, Lilianna Szyk-Warszyńska, Piotr Warszyński, Danuta Jantas
,
PMID:38473749
Protective Effects of Cannabidiol (CBD) against Qxidative Stress, but Not Excitotoxic-Related Neuronal Cell Damage-An In Vitro Study. Danuta Jantas, Monika Leśkiewicz, Magdalena Regulska, Magdalena Procner, Piotr Warszyński, Władysław Lasoń
,
PMID:38785971

More publications

Aneta Fraczek-Szczypta, Danuta Jantas, Filip Ciepiela, Justyna Grzonka. Graphene oxide-conductive polymer nanocomposite coatings obtained by the EPD method as substrates for neurite outgrowth. Diamond & Related Materials 102 (2020) 107663.
Marek Piotrowski, Danuta Jantas, Monika Leśkiewicz, Krzysztof Szczepanowicz, Piotr Warszyński, Władysław Lasoń. Polyelectrolyte-coated nanocapsules containing cyclosporine A protect neuronal-like cells against oxidative stress-induced cell damage. Colloids and Surfaces A: Physicochemical and Engineering Aspects Volume 555, 20 October 2018, Pages 264-269.
Aneta Fraczek-Szczypta, Danuta Jantas, Filip Ciepiela, Justyna Grzonka, Andrzej Bernasike, Mateusz Marzec. Carbon nanomaterials coatings – Properties and influence on nerve cells response. Diamond and Related Materials Volume 84, April 2018, Pages 127–140.
M. Szczęch, K. Szczepanowicz, D. Jantas, M. Piotrowski, A. Kida, W. Lasoń, P. Warszyński. Neuroprotective action of undecylenic acid (UDA) encapsulated into PCL nanocarriers. Colloids and Surfaces A 532 (2017) 41–47.
Marek Piotrowski, Krzysztof Szczepanowicz, Danuta Jantas, Monika Leskiewicz, Władysław Lason, Piotr Warszynski. Emulsion-core and polyelectrolyte-shell nanocapsules: biocompatibility and neuroprotection against SH-SY5Y cells. J Nanopart Res (2013) 15:1-12.
Gręda A., Jantas D. Dysfunkcje mitochondriów w chorobach neurodegeneracyjnych: potencjalny punkt uchwytu dla leków neuroprotekcyjnych. Postępy Biologii Komórki, TOM 39 2012 NR 3 (321–344). Review in Polish.
Danuta Jantas. Thyreoliberin (TRH) – the regulatory neuropeptide of CNS homeostasis. Advances in Cell Biology 2010, 2:138-152.
Jantas D. Cell-Based Systems of Depression: An Overview. In: Herbal Medicine in Depression. Ed. Clara Grosso. Springer, Switzerland 2016, p. 75-117. DOI 10.1007/978-3-319-14021-6.
Lasoń W., Jantas D. Rola epigenetyki w mechanizmach i leczeniu padaczki (The role of epigenetics in pathomechanisms and epilepsy treatment). Article In Polish. Epileptologia 2009, 17:113-122.
Jantas-Skotniczna D. Estrogeny – nie tylko hormony płciowe (Rola estrogenów w Ośrodkowym Układzie Nerwowym). [Estrogens – not only sexual hormons (The role of estrogens In Central Nervous System)]. Wszechświat, 2004; 105: 191-194. Review. Polish.
Jantas-Skotniczna D. ALS – cichy zabójca (Nasze szanse w walce ze stwardnieniem bocznym zanikowym). [ALS – the sileni killer (Our chances to combat Amyotropic Lateral Sclerosis)]. Wszechświat, 2006; 107: 31-33. Review. Polish.

The interplay of neurochemistry and cancer biology: in the search for novel glioblastoma multiforme therapy among dopamine receptor ligands - 2022-11-02 - 2025-11-01
Consortium partner in project SONATA 17 UMO-2021/43/D/NZ7/00891
Project PASIFIC Call 1 TheraLanOx "Neuroprotective properties of theranostic lanthanide oxide nanoparticles against neurotoxin-induced cellular models of Parkinson’s disease" - 2022-03-01 - 2024-02-29
Project PI: Dr Rugmani Meenambal; project supervisors: Dr hab. Danuta Jantas and Prof. dr hab. Piotr Warszyński
Hybrid carbon composites for stimulation of cells of the central nervous system - 2021-07-23 - 2025-07-22
Consortium partner in project OPUS 20 2020/39/B/ST5/02126
The study on the role of metabotropic glutamate receptor subtype 8 (mGluR8) in cancer cells - potential target for new anticancer drugs - 2013-02-11 - 2015-12-10
Grant NCN OPUS 3 2012/05/B/NZ3/00452.
The study on the neuroprotective potential of metabotropic glutamate group II and III receptors in in vitro and in vivo apoptosis models - 2010-03-12 - 2013-09-11
Grant KBN nr N N405 611638.

2020 - Bronze Cross of Merit from President of Poland; for significant contribution to science development in Poland
2021-06-29
2017 - Publons Peer Review Award, Multidisciplinary
2017-09-01
2009 - Young Investigator Award, Neuropeptides Festival, Salzburg, Austria.
2009-07-23

National

Instytut Katalizy i Fizykochemii Powierzchni PAN (Prof. Piotr Warszyński)
Katedra Technologii i Biotechnologii Środków Leczniczych, Wydział Farmaceutyczny Collegium Medicum UJ (dr Katarzyna Kucwaj-Brysz)
Wydział Inżynierii Materiałowej i Ceramiki, Katedra Biomateriałów i Kompozytów, AGH (dr hab. inż. Aneta Frączek-Szczypta, prof. AGH)

International

Medicinal Chemistry Laboratory, Department of Chemistry, Faculty of Exact Sciences, Bar-Ilan University, Ramat-Gan, Israel (Prof. Arie Gruzman)

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Danuta Jantas, PhD

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