Natalia Bryniarska, MSc


Natalia Bryniarska, MSc
Position
PhD student

  • Application of dental pulp stem cells in neural tissue regeneration

    Dental pulp stem cells (DPSCs) are a population of cells residing in mammalian dental canals. These multipotent cells show the morphology and expression of surface markers of mesenchymal stem cells: CD29, CD44, CD90, CD73. In addition, they are negative for antigens characteristic for hematopoietic stem cells such as CD45 or CD34. Their advantages are the non-invasive collection procedure and high proliferative potential. In addition, DPSCs undergo osteogenic, chondrogenic, adipogenic differentiation and due to their ectodermal origin they can also be used in the regeneration of nervous tissue. The aim of the study is to review of literature addressing possibilities of using dental pulp stem cells in the regeneration of nervous tissue. Dental pulp stem cells can be used in the regeneration of nervous tissue in both undifferentiated state through paracrine effects and also after differentiation into neurons. This process takes place in two stages with the neurospheres stage. DPSCs after differentiation show increased expression of neural cell markers and reduced expression of nestin – protein characteristic of neural stem cells, what confirms their differentiation. Using stem cells gives hope for reducing the effects of the disease for people after ischemic stroke as well as for patients suffering from neurodegenerative diseases. Dental pulp stem cells due to their ectodermal origin become an attractive alternative to other types of stem cells, such as stem cells derived from the bone marrow or umbilical cord stem cells in their use in the regeneration of damaged nervous tissue.

  • Scholarship for the best PhD students at the Maj Institute of Pharmacology Polish Academy of Sciences (2019/2020)
    2019-11-07
  • 3rd place in the competition for a popular science article for young scientists of the Polish Academy of Sciences
    2019-09-27
  • 1st place for the best presentation of the E-poster: "The use of mesenchymal stem cells in the regeneration of nervous tissue after stroke - OGD model" during the 9th National Conference - Advances in Biomedical Research
    2018-12-02
  • Scholarship for the best PhD students at the Maj Institute of Pharmacology Polish Academy of Sciences (2018/2019)
    2018-11-27
  • 2nd place in the "Best Experimental Poster" category: "Human dental pulp stem cells and umbilical-cord mesenchymal stem cells - characteristic of phenotype and multilineage differentiation properties" during the 4th International Conference of Cell Biology
    2018-05-12
  • Erasmus + scholarship for an internship at the Mario Negri Institute for Pharmacological Research, Milan, Italy
    2018-02-16
  • 1st place for the lecture "Optimization of isolation and differentiation of human dental pulp stem cells" in the Regenerative Medicine session during the VIII National Conference - Advances in Biomedical Research
    2017-12-17
  • Scholarship for the best PhD students at the Institute of Pharmacology of the Polish Academy of Sciences (2017/2018)
    2017-11-07