Employees - Institute of Pharmacology - Polish Academy of Sciences

Spectroscopic characterization and in vitro studies of biological activity of bradykinin derivatives. Edyta Proniewicz, Grzegorz Burnat, Helena Domin, Emilia Iłowska, Adam Roman, Adam Prahl
Scientific reports, 10.1038/s41598-022-23448-7
PMID:36348016

Group III metabotropic glutamate receptors as promising targets for neuroprotective therapy: Particular emphasis on the role of mGlu4 and mGlu7 receptors. Helena Domin
Pharmacology, biochemistry, and behavior, S0091-3057(22)00131-9 10.1016/j.pbb.2022.173452
PMID:36030890

Application of Alanine Scanning to Determination of Amino Acids Essential for Peptide Adsorption at the Solid/Solution Interface and Binding to the Receptor: Surface-Enhanced Raman/Infrared Spectroscopy versus Bioactivity Assays. Edyta Proniewicz, Grzegorz Burnat, Helena Domin, Izabela Małuch, Marta Makowska, Adam Prahl
Journal of medicinal chemistry, 10.1021/acs.jmedchem.1c00397
PMID:34110823

A role of noradrenergic receptors in anxiolytic-like effect of high CRF in the rat frontal cortex. Maria Śmiałowska, Barbara Zięba, Helena Domin
Neuropeptides, S0143-4179(21)00048-2 10.1016/j.npep.2021.102162
PMID:34062382

Neuropeptide Y Y2 and Y5 receptors as potential targets for neuroprotective and antidepressant therapies: Evidence from preclinical studies. Helena Domin
Progress in neuro-psychopharmacology & biological psychiatry, S0278-5846(21)00108-1 10.1016/j.pnpbp.2021.110349
PMID:33991587

Ketamine and Ro 25-6981 Reverse Behavioral Abnormalities in Rats Subjected to Dietary Zinc Restriction. Bartłomiej Pochwat, Helena Domin, Anna Rafało-Ulińska, Bernadeta Szewczyk, Gabriel Nowak
International journal of molecular sciences, E4791 10.3390/ijms21134791
PMID:32640759

undefined Paulina Cieślik, Helena Domin, Agnieszka Chocyk, Piotr Gruca, Ewa Litwa, Agata Płoska, Adrianna Radulska, Iwona Pelikant-Małecka, Piotr Brański, Leszek Kalinowski, Joanna M Wierońska
Neuropharmacology, S0028-3908(19)30432-0 10.1016/j.neuropharm.2019.107866
PMID:31785263

Characterization of the Brain Penetrant Neuropeptide Y Y2 Receptor Antagonist SF-11. Helena Domin, Natalia Piergies, Ewa Pięta, Elżbieta Wyska, Bartłomiej Pochwat, Piotr Wlaź, Maria Śmiałowska, Czesława Paluszkiewicz, Bernadeta Szewczyk
ACS chemical neuroscience, 10.1021/acschemneuro.9b00082
PMID:31267743

Neuroprotective effect of the group III mGlu receptor agonist ACPT-I after ischemic stroke in rats with essential hypertension. Helena Domin, Łukasz Przykaza, Ewa Kozniewska, Paweł M Boguszewski, Maria Śmiałowska
Progress in neuro-psychopharmacology & biological psychiatry, S0278-5846(17)30736-4 10.1016/j.pnpbp.2018.02.006
PMID:29438731

Involvement of extracellular signal-regulated kinase (ERK) in the short and long-lasting antidepressant-like activity of NMDA receptor antagonists (zinc and Ro 25-6981) in the forced swim test in rats. Bartłomiej Pochwat, Anna Rafało-Ulińska, Helena Domin, Paulina Misztak, Gabriel Nowak, Bernadeta Szewczyk
Neuropharmacology, S0028-3908(17)30373-8 10.1016/j.neuropharm.2017.08.006
PMID:28802646

Neuropeptide Y Y2 and Y5 receptors as promising targets for neuroprotection in primary neurons exposed to oxygen-glucose deprivation and in transient focal cerebral ischemia in rats. Helena Domin, Łukasz Przykaza, Danuta Jantas, Ewa Kozniewska, Paweł M Boguszewski, Maria Śmiałowska
Neuroscience, S0306-4522(16)30740-0 10.1016/j.neuroscience.2016.12.040
PMID:28057538

Antidepressant-like activity of the neuropeptide Y Y5 receptor antagonist Lu AA33810: behavioral, molecular, and immunohistochemical evidence. Helena Domin, Bernadeta Szewczyk, Bartłomiej Pochwat, Monika Woźniak, Maria Śmiałowska
Psychopharmacology,
PMID:27975125

SERS characterization of neuropeptide Y and its C-terminal fragments deposited onto colloidal gold nanoparticle surface. Helena Domin, Natalia Piergies, Dominika Święch, Ewa Pięta, Edyta Proniewicz
Colloids and surfaces. B, Biointerfaces, S0927-7765(16)30704-4 10.1016/j.colsurfb.2016.10.001
PMID:27736725

Neuroprotective potential of the group III mGlu receptor agonist ACPT-I in animal models of ischemic stroke: in vitro and in vivo studies. Helena Domin, Łukasz Przykaza, Danuta Jantas, Ewa Kozniewska, Paweł M Boguszewski, Maria Śmiałowska
Neuropharmacology, S0028-3908(15)30189-1 10.1016/j.neuropharm.2015.11.025
PMID:26647070

Adaptive down-regulation of the serotonin transporter in the 6-hydroxydopamine induced rat model of preclinical stages of Parkinson's disease and after chronic pramipexole treatment. Klemencja Berghauzen-Maciejewska, Jadwiga Wardas, Barbara Kosmowska, Helena Domin, Maria Śmiałowska, Urszula Głowacka, Krystyna Ossowska
Neuroscience, S0306-4522(15)01048-9 10.1016/j.neuroscience.2015.11.049
PMID:26628402

Activation of mTOR dependent signaling pathway is a necessary mechanism of antidepressant-like activity of zinc. Bernadeta Szewczyk, Bartłomiej Pochwat, Anna Rafało, Agnieszka Palucha-Poniewiera, Helena Domin, Gabriel Nowak
Neuropharmacology, 10.1016/j.neuropharm.2015.08.026 S0028-3908(15)30071-X
PMID:26297535

Neuroprotective effects of the allosteric agonist of metabotropic glutamate receptor 7 AMN082 on oxygen-glucose deprivation- and kainate-induced neuronal cell death. Helena Domin, Danuta Jantas, Maria Śmiałowska
Neurochemistry international, 10.1016/j.neuint.2014.12.010 S0197-0186(15)00002-9
PMID:25576184

Neuropeptide Y and its C-terminal fragments acting on Y2 receptor: Raman and SERS spectroscopy studies. Helena Domin, Ewa Pięta, Natalia Piergies, Dominika Święch, Younkyoo Kim, Leonard M Proniewicz, Edyta Proniewicz
Journal of colloid and interface science, 10.1016/j.jcis.2014.09.053 S0021-9797(14)00702-4
PMID:25313473

Antidepressant-like effect of the mGluR5 antagonist MTEP in an astroglial degeneration model of depression. Helena Domin, Bernadeta Szewczyk, Monika Woźniak, Anika Wawrzak-Wleciał, Maria Śmiałowska
Behavioural brain research, 10.1016/j.bbr.2014.07.019 S0166-4328(14)00466-5
PMID:25043733

Group III mGlu receptor agonist, ACPT-I, exerts potential neuroprotective effects in vitro and in vivo. Helena Domin, Krystyna Gołembiowska, Danuta Jantas, Katarzyna Kamińska, Barbara Zięba, Maria Smiałowska
Neurotoxicity research, 10.1007/s12640-013-9455-7
PMID:24402869

Lack of neuroprotective effect of celastrol under conditions of proteasome inhibition by lactacystin in in vitro and in vivo studies: implications for Parkinson's disease. Jolanta Konieczny, Danuta Jantas, Tomasz Lenda, Helena Domin, Anna Czarnecka, Katarzyna Kuter, Maria Śmiałowska, Władysław Lasoń, Elżbieta Lorenc-Koci
Neurotoxicity research, 10.1007/s12640-014-9477-9
PMID:24842651

Glial degeneration as a model of depression. Maria Smiałowska, Bernadeta Szewczyk, Monika Woźniak, Anika Wawrzak-Wleciał, Helena Domin
Pharmacological reports : PR,
PMID:24553005

Alterations in the expression of nNOS in the substantia nigra and subthalamic nucleus of 6-OHDA-lesioned rats: the effects of chronic treatment with l-DOPA and the nitric oxide donor, molsidomine. Anna Czarnecka, Tomasz Lenda, Helena Domin, Jolanta Konieczny, Maria Smiałowska, Elżbieta Lorenc-Koci
Brain research, 10.1016/j.brainres.2013.10.011 S0006-8993(13)01376-0
PMID:24129225

Anxiolytic-like activity of MGS0039, a selective group II mGlu receptor antagonist, is serotonin- and GABA-dependent. Katarzyna Stachowicz, Joanna Wierońska, Helena Domin, Shigeyuki Chaki, Andrzej Pilc
Pharmacological reports : PR,
PMID:22001975

Selective mGluR1 antagonist EMQMCM inhibits the kainate-induced excitotoxicity in primary neuronal cultures and in the rat hippocampus. Maria Śmiałowska, Krystyna Gołembiowska, Małgorzata Kajta, Barbara Zięba, Anna Dziubina, Helena Domin
Neurotoxicity research, 10.1007/s12640-011-9293-4
PMID:22144346

Different effects of intranigral and intrastriatal administration of the proteasome inhibitor lactacystin on typical neurochemical and histological markers of Parkinson's disease in rats. Elżbieta Lorenc-Koci, Tomasz Lenda, Lucyna Antkiewicz-Michaluk, Jadwiga Wardas, Helena Domin, Maria Smiałowska, Jolanta Konieczny
Neurochemistry international, 10.1016/j.neuint.2011.03.013
PMID:21419185

Neuroprotective potential of mGluR5 antagonist MTEP: effects on kainate-induced excitotoxicity in the rat hippocampus. Helena Domin, Barbara Zięba, Krystyna Gołembiowska, Magdalena Kowalska, Anna Dziubina, Maria Śmiałowska
Pharmacological reports : PR,
PMID:21273662

Neuroprotection by co-treatment and post-treating with calcitriol following the ischemic and excitotoxic insult in vivo and in vitro. Małgorzata Kajta, Dorota Makarewicz, Elzbieta Ziemińska, Danuta Jantas, Helena Domin, Władysław Lasoń, Andrzej Kutner, Jerzy W Łazarewicz
Neurochemistry international, 10.1016/j.neuint.2009.03.010
PMID:19576513

Neuroprotective effects of neuropeptide Y-Y2 and Y5 receptor agonists in vitro and in vivo. Maria Smiałowska, Helena Domin, Barbara Zieba, Ewa Koźniewska, Radosław Michalik, Piotr Piotrowski, Małgorzata Kajta
Neuropeptides, 10.1016/j.npep.2009.02.002
PMID:19318226

The behavioural and electrophysiological effects of CRF in rat frontal cortex. Barbara Zieba, Małgorzata Grzegorzewska, Piotr Brański, Helena Domin, Joanna M Wierońska, Grzegorz Hess, Maria Smiałowska
Neuropeptides, 10.1016/j.npep.2008.05.004
PMID:18617263

The effect of intrahippocampal injection of group II and III metobotropic glutamate receptor agonists on anxiety; the role of neuropeptide Y. Maria Smiałowska, Joanna M Wierońska, Helena Domin, Barbara Zieba
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
PMID:17133262

Neuroprotective effects of MTEP, a selective mGluR5 antagonists and neuropeptide Y on the kainate-induced toxicity in primary neuronal cultures. Helena Domin, Małgorzata Kajta, Maria Smiałowska
Pharmacological reports : PR,
PMID:17220542

Genistein inhibits glutamate-induced apoptotic processes in primary neuronal cell cultures: an involvement of aryl hydrocarbon receptor and estrogen receptor/glycogen synthase kinase-3beta intracellular signaling pathway. M Kajta, H Domin, G Grynkiewicz, W Lason
Neuroscience,
PMID:17261353

The antidepressant-like and glioprotective effects of the Y2 receptor antagonist SF-11 in the astroglial degeneration model of depression in rats: Involvement of glutamatergic inhibition. Helena Domin, Jolanta Konieczny, Paulina Cieślik, Bartłomiej Pochwat, Elżbieta Wyska, Małgorzata Szafarz, Tomasz Lenda, Dominika Biała, Łukasz Gąsior, Maria Śmiałowska, Bernadeta Szewczyk
,
PMID:37871655

Helena Domin, PhD

National

International

interests

keywords

contact

links

Website editor