Employees - Institute of Pharmacology - Polish Academy of Sciences

The Effect of the Selective N-methyl-D-aspartate (NMDA) Receptor GluN2B Subunit Antagonist CP-101,606 on Cytochrome P450 2D (CYP2D) Expression and Activity in the Rat Liver and Brain. Anna Haduch, Ewa Bromek, Renata Pukło, Joanna Jastrzębska, Przemysław Jan Danek, Władysława Anna Daniel
International journal of molecular sciences, 13746 10.3390/ijms232213746
PMID:36430225

The Atypical Antipsychotic Lurasidone Affects Brain but Not Liver Cytochrome P450 2D (CYP2D) Activity. A Comparison with Other Novel Neuroleptics and Significance for Drug Treatment of Schizophrenia. Przemysław J Danek, Władysława A Daniel
Cells, 3513 10.3390/cells11213513
PMID:36359909

The impact of noradrenergic neurotoxin DSP-4 and noradrenaline transporter knockout (NET-KO) on the activity of liver cytochrome P450 3A (CYP3A) in male and female mice. Ewa Bromek, Przemysław Jan Danek, Jacek Wójcikowski, Agnieszka Basińska-Ziobroń, Renata Pukło, Joanna Solich, Marta Dziedzicka-Wasylewska, Władysława Anna Daniel
Pharmacological reports : PR, 10.1007/s43440-022-00406-8
PMID:36018449

The mechanisms of interactions of psychotropic drugs with liver and brain cytochrome P450 and their significance for drug effect and drug-drug interactions. Władysława A Daniel, Ewa Bromek, Przemysław J Danek, Anna Haduch
Biochemical pharmacology, S0006-2952(22)00100-9 10.1016/j.bcp.2022.115006
PMID:35314167

Long-Term Treatment with Atypical Antipsychotic Iloperidone Modulates Cytochrome P450 2D (CYP2D) Expression and Activity in the Liver and Brain via Different Mechanisms. Przemysław J Danek, Władysława A Daniel
Cells, 3472 10.3390/cells10123472
PMID:34943983

Cytochrome P450 2D (CYP2D) enzyme dysfunction associated with aging and serotonin deficiency in the brain and liver of female Dark Agouti rats. Anna Haduch, Przemysław J Danek, Wojciech Kuban, Renata Pukło, Natalia Alenina, Joanna Gołębiowska, Piotr Popik, Michael Bader, Władysława A Daniel
Neurochemistry international, S0197-0186(21)00269-2 10.1016/j.neuint.2021.105223
PMID:34780807

Chronic treatment with asenapine affects cytochrome P450 2D (CYP2D) in rat brain and liver. Pharmacological aspects. Przemysław J Danek, Ewa Bromek, Anna Haduch, Władysława A Daniel
Neurochemistry international, S0197-0186(21)00255-2 10.1016/j.neuint.2021.105209
PMID:34666077

The Selective NMDA Receptor GluN2B Subunit Antagonist CP-101,606 with Antidepressant Properties Modulates Cytochrome P450 Expression in the Liver. Ewa Bromek, Anna Haduch, Marta Rysz, Joanna Jastrzębska, Renata Pukło, Olga Wójcikowska, Przemysław Jan Danek, Władysława Anna Daniel
Pharmaceutics, 1643 10.3390/pharmaceutics13101643
PMID:34683936

The Effect of Chronic Iloperidone Treatment on Cytochrome P450 Expression and Activity in the Rat Liver: Involvement of Neuroendocrine Mechanisms. Przemysław J Danek, Wojciech Kuban, Władysława A Daniel
International journal of molecular sciences, 8447 10.3390/ijms22168447
PMID:34445153

The Influence of Long-Term Treatment with Asenapine on Liver Cytochrome P450 Expression and Activity in the Rat. The Involvement of Different Mechanisms. Przemysław J Danek, Ewa Bromek, Władysława A Daniel
Pharmaceuticals (Basel, Switzerland), 629 10.3390/ph14070629
PMID:34209648

Asenapine and iloperidone decrease the expression of major cytochrome P450 enzymes CYP1A2 and CYP3A4 in human hepatocytes. A significance for drug-drug interactions during combined therapy. Przemysław J Danek, Jacek Wójcikowski, Władysława A Daniel
Toxicology and applied pharmacology, S0041-008X(20)30365-3 10.1016/j.taap.2020.115239
PMID:32941854

Levomepromazine and clozapine induce the main human cytochrome P450 drug metabolizing enzyme CYP3A4. Przemysław J Danek, Agnieszka Basińska-Ziobroń, Jacek Wójcikowski, Władysława A Daniel
Pharmacological reports : PR, 10.1007/s43440-020-00157-4
PMID:32888176

The atypical neuroleptics iloperidone and lurasidone inhibit human cytochrome P450 enzymes in vitro. Evaluation of potential metabolic interactions. Przemysław J Danek, Jacek Wójcikowski, Władysława A Daniel
Pharmacological reports : PR, 10.1007/s43440-020-00102-5
PMID:32279279

In vitro inhibition of human cytochrome P450 enzymes by the novel atypical antipsychotic drug asenapine: a prediction of possible drug-drug interactions. Jacek Wójcikowski, Przemysław J Danek, Agnieszka Basińska-Ziobroń, Renata Pukło, Władysława A Daniel
Pharmacological reports : PR, 10.1007/s43440-020-00089-z
PMID:32219694

The effect of brain serotonin deficit (TPH2-KO) on the expression and activity of liver cytochrome P450 enzymes in aging male Dark Agouti rats. Anna Haduch, Ewa Bromek, Wojciech Kuban, Agnieszka Basińska-Ziobroń, Przemysław J Danek, Natalia Alenina, Michael Bader, Władysława A Daniel
,
PMID:37848703

The Novel Atypical Antipsychotic Lurasidone Affects Cytochrome P450 Expression in the Liver and Peripheral Blood Lymphocytes. Przemysław J Danek, Władysława A Daniel
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PMID:38069119

Przemysław Danek, PhD