Agnieszka Chocyk, PhD

Position
Adjunct

Department
Department of Pharmacology

chocyk@if-pan.krakow.pl

+48 12 6623229

room: 237

Diplomas, academic degrees:

- Habilitation in biomedical sciences, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland – May 2015,

- Ph.D. in biomedical sciences, Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland – February 2005,

- M.Sc. in biology, Department of Microbiology and Immunology, Institute of Molecular Biology, Jagiellonian University, Kraków, Poland – September 1996

Scientific interests:

- The effects of early-life stress on brain maturation and functions: focus on the medial prefrontal cortex, substantia nigra and VTA

- Maturation and plasticity of the medial prefrontal cortex during adolescence

- Early-life stress as important environmental factor in etiology of anxiety, mood disorders and addiction

- The mechanisms of resilience and vulnerability to stress-related psychopathologies

- The interaction between dopaminergic system and the hypothalamic-pituitary-adrenal axis

Early-life stress affects peripheral, blood-brain barrier, and brain responses to immune challenge in juvenile and adult rats. Anna Solarz, Iwona Majcher-Maślanka, Joanna Kryst, Agnieszka Chocyk
Brain, behavior, and immunity, 10.1016/j.bbi.2022.11.005 S0889-1591(22)00434-2
PMID:36400335
Effects of chronic fluoxetine treatment on anxiety- and depressive-like behaviors in adolescent rodents - systematic review and meta-analysis. Joanna Kryst, Iwona Majcher-Maślanka, Agnieszka Chocyk
Pharmacological reports : PR, 10.1007/s43440-022-00420-w
PMID:36151445
Effects of early-life stress and sex on blood-brain barrier permeability and integrity in juvenile and adult rats. Anna Solarz, Iwona Majcher-Maślanka, Agnieszka Chocyk
Developmental neurobiology, 10.1002/dneu.22846
PMID:34320279
A Search for Biomarkers of Early-life Stress-related Psychopathology: Focus on 70-kDa Heat Shock Proteins. Anna Solarz, Iwona Majcher-Maślanka, Joanna Kryst, Agnieszka Chocyk
Neuroscience, S0306-4522(21)00106-8 10.1016/j.neuroscience.2021.02.026
PMID:33662529
1MeTIQ and olanzapine, despite their neurochemical impact, did not ameliorate performance in fear conditioning and social interaction tests in an MK-801 rat model of schizophrenia. Magdalena Białoń, Agnieszka Chocyk, Iwona Majcher-Maślanka, Marcelina Żarnowska, Krzysztof Michalski, Lucyna Antkiewicz-Michaluk, Agnieszka Wąsik
Pharmacological reports : PR, 10.1007/s43440-020-00209-9
PMID:33403530
The Trace Kynurenine, Cinnabarinic Acid, Displays Potent Antipsychotic-Like Activity in Mice and Its Levels Are Reduced in the Prefrontal Cortex of Individuals Affected by Schizophrenia. Martina Ulivieri, Joanna Monika Wierońska, Luana Lionetto, Katiuscia Martinello, Paulina Cieslik, Agnieszka Chocyk, Martina Curto, Luisa Di Menna, Luisa Iacovelli, Anna Traficante, Francesca Liberatore, Giada Mascio, Nico Antenucci, Giuseppe Giannino, Matteo Vergassola, Anna Pittaluga, Valeria Bruno, Giuseppe Battaglia, Sergio Fucile, Maurizio Simmaco, Ferdinando Nicoletti, Andrzej Pilc, Francesco Fazio
Schizophrenia bulletin, 10.1093/schbul/sbaa074
PMID:32506121
Maternal separation disturbs postnatal development of the medial prefrontal cortex and affects the number of neurons and glial cells in adolescent rats. Iwona Majcher-Maślanka, Anna Solarz, Agnieszka Chocyk
Neuroscience, S0306-4522(19)30725-0 10.1016/j.neuroscience.2019.10.033
PMID:31705889
The impact of early-life stress on corticosteroid carrier protein levels and 11β-hydroxysteroid dehydrogenase 1 expression in adolescent rats. Iwona Majcher-Maślanka, Anna Solarz, Agnieszka Chocyk
Pharmacological reports : PR, S1734-1140(18)30463-8 10.1016/j.pharep.2018.11.003
PMID:30831440
Previous Early-life Stress Modifies Acute Corticosterone-induced Synaptic Plasticity in the Medial Prefrontal Cortex of Adolescent Rats. Iwona Majcher-Maślanka, Anna Solarz, Krzysztof Wędzony, Agnieszka Chocyk
Neuroscience, S0306-4522(18)30229-X 10.1016/j.neuroscience.2018.03.038
PMID:29608944
The effects of early-life stress on dopamine system function in adolescent female rats. Iwona Majcher-Maślanka, Anna Solarz, Krzysztof Wędzony, Agnieszka Chocyk
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, S0736-5748(16)30336-7 10.1016/j.ijdevneu.2017.01.001
PMID:28065748
Early-life stress increases the survival of midbrain neurons during postnatal development and enhances reward-related and anxiolytic-like behaviors in a sex-dependent fashion. Agnieszka Chocyk, Iwona Majcher-Maślanka, Aleksandra Przyborowska, Marzena Maćkowiak, Krzysztof Wędzony
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, S0736-5748(15)00409-8 10.1016/j.ijdevneu.2015.05.002
PMID:25980793
Potential roles of NCAM/PSA-NCAM proteins in depression and the mechanism of action of antidepressant drugs. Krzysztof Wędzony, Agnieszka Chocyk, Marzena Maćkowiak
Pharmacological reports : PR,
PMID:24552994
The effects of early-life adversity on fear memories in adolescent rats and their persistence into adulthood. Agnieszka Chocyk, Aleksandra Przyborowska, Wioletta Makuch, Iwona Majcher-Maślanka, Dorota Dudys, Krzysztof Wędzony
Behavioural brain research, 10.1016/j.bbr.2014.01.040 S0166-4328(14)00054-0
PMID:24508235
Impact of early-life stress on the medial prefrontal cortex functions - a search for the pathomechanisms of anxiety and mood disorders. Agnieszka Chocyk, Iwona Majcher-Maślanka, Dorota Dudys, Aleksandra Przyborowska, Krzysztof Wędzony
Pharmacological reports : PR,
PMID:24552993
Early-life stress affects the structural and functional plasticity of the medial prefrontal cortex in adolescent rats. Agnieszka Chocyk, Bartosz Bobula, Dorota Dudys, Aleksandra Przyborowska, Iwona Majcher-Maślanka, Grzegorz Hess, Krzysztof Wędzony
The European journal of neuroscience, 10.1111/ejn.12208
PMID:23581639
Impact of maternal separation on neural cell adhesion molecules expression in dopaminergic brain regions of juvenile, adolescent and adult rats. Agnieszka Chocyk, Dorota Dudys, Aleksandra Przyborowska, Marzena Maćkowiak, Krzysztof Wędzony
Pharmacological reports : PR,
PMID:21273681
The impact of maternal separation on the number of tyrosine hydroxylase-expressing midbrain neurons during different stages of ontogenesis. A Chocyk, A Przyborowska, D Dudys, I Majcher, M Maćkowiak, K Wędzony
Neuroscience, 10.1016/j.neuroscience.2011.03.008
PMID:21396433
Maternal separation affects the number, proliferation and apoptosis of glia cells in the substantia nigra and ventral tegmental area of juvenile rats. A Chocyk, D Dudys, A Przyborowska, I Majcher, M Maćkowiak, K Wędzony
Neuroscience, 10.1016/j.neuroscience.2010.11.037
PMID:21108994
Impact of postnatal dexamethasone on psychotomimetic effects of MK-801 measured on adult rats. Krzysztof Wedzony, Katarzyna Markowicz-Kula, Agnieszka Chocyk, Katarzyna Fijał, Aleksandra Przyborowska, Marzena Maćkowiak
Pharmacological reports : PR,
PMID:20081238
Cannabinoid CB1 receptors in rat medial prefrontal cortex are colocalized with calbindin- but not parvalbumin- and calretinin-positive GABA-ergic neurons. Krzysztof Wedzony, Agnieszka Chocyk
Pharmacological reports : PR,
PMID:20081234
Peripheral antinociceptive effects of MC4 receptor antagonists in a rat model of neuropathic pain - a biochemical and behavioral study. Katarzyna Starowicz, Shaaban A Mousa, Ilona Obara, Agnieszka Chocyk, Ryszard Przewłocki, Krzysztof Wedzony, Halina Machelska, Barbara Przewłocka
Pharmacological reports : PR,
PMID:20081244
Detrimental effect of postnatal blockade of N-methyl-D-aspartate receptors on sensorimotor gating is reversed by neuroleptic drugs. Krzysztof Wedzony, Katarzyna Fijał, Marzena Maćkowiak, Agnieszka Chocyk
Pharmacological reports : PR,
PMID:19211977
Activation of CB1 cannabinoid receptors impairs memory consolidation and hippocampal polysialylated neural cell adhesion molecule expression in contextual fear conditioning. M Maćkowiak, A Chocyk, D Dudys, K Wedzony
Neuroscience, 10.1016/j.neuroscience.2008.11.037
PMID:19110037
Repeated risperidone treatment increases the expression of NCAM and PSA-NCAM protein in the rat medial prefrontal cortex. Marzena Maćkowiak, Dorota Dudys, Agnieszka Chocyk, Krzysztof Wedzony
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 10.1016/j.euroneuro.2008.10.001
PMID:19042107
A search for colocalization of serotonin 5-HT2A and 5-HT1A receptors in the rat medial prefrontal and entorhinal cortices--immunohistochemical studies. K Wedzony, A Chocyk, M Maćkowiak
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
PMID:18622042
Dopamine D1-like receptors agonist SKF 38393 increases cFOS expression in the paraventricular nucleus of the hypothalamus--impact of acute and chronic cocaine. A Chocyk, A Czyrak, K Wedzony
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
PMID:18953088
Cocaine decreases the expression of PSA-NCAM protein and attenuates long-term potentiation via glucocorticoid receptors in the rat dentate gyrus. Marzena Maćkowiak, Małgorzata Grzegorzewska, Bogusława Budziszewska, Agnieszka Chocyk, Grzegorz Hess, Krzysztof Wedzony
The European journal of neuroscience, 10.1111/j.1460-9568.2008.06255.x
PMID:18588533
Glutamatergic neurons of rat medial prefrontal cortex innervating the ventral tegmental area are positive for serotonin 5-HT1A receptor protein. K Wedzony, A Chocyk, W Kolasiewicz, M Maćkowiak
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
PMID:18195476
Impact of postnatal blockade of N-methyl-D-aspartate receptors on rat behavior: a search for a new developmental model of schizophrenia. K Wedzony, K Fijal, M Mackowiak, A Chocyk, W Zajaczkowski
Neuroscience, 10.1016/j.neuroscience.2008.03.016
PMID:18434025
Acute activation of CB1 cannabinoid receptors transiently decreases PSA-NCAM expression in the dentate gyrus of the rat hippocampus. Marzena Maćkowiak, Agnieszka Chocyk, Katarzyna Markowicz-Kula, Krzysztof Wedzony
Brain research,
PMID:17355876
Neurogenesis in the adult brain. Marzena Maćkowiak, Agnieszka Chocyk, Katarzyna Markowicz-Kula, Krzysztof Wedzony
Polish journal of pharmacology,
PMID:15662080
Acute and repeated cocaine induces alterations in FosB/DeltaFosB expression in the paraventricular nucleus of the hypothalamus. Agnieszka Chocyk, Anna Czyrak, Krzysztof Wedzony
Brain research,
PMID:16674926
The effect of 'binge' cocaine administration on the expression of cyclin-dependent kinase 5 and its activator p35 in various regions of rat brain. Krzysztof Wedzony, Katarzyna Markowicz-Kula, Agnieszka Chocyk, Katarzyna Fijał, Marzena Maćkowiak
Brain research,
PMID:16263094
Blockade of NMDA receptors in postnatal period decreased density of tyrosine hydroxylase immunoreactive axonal arbors in the medial prefrontal cortex of adult rats. K Wedzony, K Fijał, A Chocyk
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
PMID:15985703
Regulation of alpha-synuclein expression in limbic and motor brain regions of morphine-treated mice. Barbara Ziolkowska, Agnieszka Gieryk, Wiktor Bilecki, Agnieszka Wawrzczak-Bargiela, Krzysztof Wedzony, Agnieszka Chocyk, Patria E Danielson, Elizabeth A Thomas, Brian S Hilbush, J Gregor Sutcliffe, Ryszard Przewlocki
The Journal of neuroscience : the official journal of the Society for Neuroscience,
PMID:15901780
Role of glucocorticoids in the regulation of dopaminergic neurotransmission. Anna Czyrak, Marzena Maćkowiak, Agnieszka Chocyk, Katarzyna Fijał, Krzystof Wedzony
Polish journal of pharmacology,
PMID:14704461
Serotonin 5-HT1A receptors might control the output of cortical glutamatergic neurons in rat cingulate cortex. Anna Czyrak, Klaudia Czepiel, Marzena Maćkowiak, Agnieszka Chocyk, Krzysztof Wedzony
Brain research,
PMID:14519510
Different pattern of brain c-Fos expression following re-exposure to ethanol or sucrose self-administration environment. Krzysztof Wedzony, Eliza Koros, Anna Czyrak, Agnieszka Chocyk, Klaudia Czepiel, Katarzyna Fijal, Marzena Mackowiak, Artur Rogowski, Wojciech Kostowski, Przemyslaw Bienkowski
Naunyn-Schmiedeberg's archives of pharmacology,
PMID:14574439
Endomorphin-2, deltorphin II and their analogs suppress formalin-induced nociception and c-Fos expression in the rat spinal cord. Dominika Labuz, Agnieszka Chocyk, Krzysztof Wedzony, Geza Toth, Barbara Przewlocka
Life sciences,
PMID:12759135
8-OHDPAT-induced disruption of prepulse inhibition in rats is attenuated by prolonged corticosterone treatment. Anna Czyrak, Marzena Maćkowiak, Agnieszka Chocyk, Katarzyna Fijał, Anna Gadek-Michalska, Krzysztof Wedzony
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
PMID:12700680
DOI, an agonist of 5-HT2A/2C serotonin receptor, alters the expression of cyclooxygenase-2 in the rat parietal cortex. M Mackowiak, A Chocyk, M Sanak, A Czyrak, K Fijał, K Wedzony
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
PMID:12369737
Search for the presence of glucocorticoid receptors in dopaminergic neurons of rat ventral tegmental area and substantia nigra. A Czyrak, A Chocyk
Polish journal of pharmacology,
PMID:11985346
Prolonged corticosterone treatment alters the responsiveness of 5-HT1A receptors to 8-OH-DPAT in rat CA1 hippocampal neurons. Anna Czyrak, Marzena Maćkowiak, Agnieszka Chocyk, Katarzyna Fijał, Krzysztof Tokarski, Maria Bijak, Krzysztof Wedzony
Naunyn-Schmiedeberg's archives of pharmacology,
PMID:12237750
[Distribution of dopamine D1 receptors in the paraventricular nucleus of the rat hypothalamus and their colocalization with phosphorylated forms of CREB protein]. A Chocyk, K Szumierz, K Wedzony, A Czyrak
Folia medica Cracoviensia,
PMID:11339018
Distribution of dopamine D1 receptors in the nucleus paraventricularis of the hypothalamus in rats: an immunohistochemical study. A Czyrak, A Chocyk, M Maćkowiak, K Fijał, K Wedzony
Brain research. Molecular brain research,
PMID:11146123
WAY 100135, an antagonist of 5-HT1A serotonin receptors, attenuates psychotomimetic effects of MK-801. K Wedzony, M Maćkowiak, W Zajaczkowski, K Fijał, A Chocyk, A Czyrak
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
PMID:11027920
Cortical localization of dopamine D4 receptors in the rat brain--immunocytochemical study. K Wedzony, A Chocyk, M Maćkowiak, K Fijał, A Czyrak
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society,
PMID:10898094
c-Fos proteins, induced by the serotonin receptor agonist DOI, are not expressed in 5-HT2A positive cortical neurons. M Maćkowiak, A Chocyk, K Fijał, A Czyrak, K Wedzony
Brain research. Molecular brain research,
PMID:10521592
Impact of metyrapone on MK-801-induced alterations in the rat dopamine D1 receptors. A Czyrak, M Maćkowiak, K Fijał, A Chocyk, K Wedzony
Polish journal of pharmacology,
PMID:9566029

More publications

The role of endoplasmic reticulum stress in the pathomechanisms of early-life stressinduced dysfunction of the prefronatal cortex and in the mechanisms of action of fluoxetine in children and adolescents - 2018-01-03 - 2021-01-02
- 2016-01-04 - 2018-05-01
- 2010-01-01 - 2014-01-02

Agnieszka Chocyk, PhD

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