Employees - Institute of Pharmacology - Polish Academy of Sciences

The Formyl Peptide Receptor 2 as a Target For Promotion of Resolution of Inflammation. Ewa Trojan, Monika Leśkiewicz, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
Current neuropharmacology, 10.2174/1570159X20666220913155248
PMID:36100993

Quetiapine Ameliorates MIA-Induced Impairment of Sensorimotor Gating: Focus on Neuron-Microglia Communication and the Inflammatory Response in the Frontal Cortex of Adult Offspring of Wistar Rats. Katarzyna Chamera, Katarzyna Curzytek, Kinga Kamińska, Ewa Trojan, Agnieszka Basta-Kaim
Cells, 2788 10.3390/cells11182788
PMID:36139363

Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Ureidopropanamides as Formyl Peptide Receptor 2 (FPR2) Agonists to Target the Resolution of Inflammation in Central Nervous System Disorders. Margherita Mastromarino, Maria Favia, Igor A Schepetkin, Lylia N Kirpotina, Ewa Trojan, Mauro Niso, Antonio Carrieri, Monika Leśkiewicz, Magdalena Regulska, Massimiliano Darida, Francesco Rossignolo, Stefano Fontana, Mark T Quinn, Agnieszka Basta-Kaim, Marcello Leopoldo, Enza Lacivita
Journal of medicinal chemistry, 10.1021/acs.jmedchem.1c02203
PMID:35257581

The emerging role for the double-edged impact of arachidonic acidderived eicosanoids in the neuroinflammatory background of depression. Magdalena Regulska, Magdalena Szuster-Głuszczak, Ewa Trojan, Monika Leśkiewicz, Agnieszka Basta-Kaim
Current neuropharmacology, 10.2174/1570159X18666200807144530
PMID:32851950

Time-Dependent Protective and Pro-Resolving Effects of FPR2 Agonists on Lipopolysaccharide-Exposed Microglia Cells Involve Inhibition of NF-κB and MAPKs Pathways. Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Magdalena Regulska, Natalia Bryniarska, Katarzyna Curzytek, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
Cells, 2373 10.3390/cells10092373
PMID:34572022

The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Improves Ex Vivo and In Vivo Amyloid Beta (1-42)-Induced Neuroinflammation in Mouse Models of Alzheimer's Disease. Ewa Trojan, Kinga Tylek, Nicole Schröder, Iris Kahl, Lars-Ove Brandenburg, Margherita Mastromarino, Marcello Leopoldo, Agnieszka Basta-Kaim, Enza Lacivita
Molecular neurobiology, 10.1007/s12035-021-02543-2
PMID:34468933

The N-Formyl Peptide Receptor 2 (FPR2) Agonist MR-39 Exhibits Anti-Inflammatory Activity in LPS-Stimulated Organotypic Hippocampal Cultures. Ewa Trojan, Kinga Tylek, Monika Leśkiewicz, Władysław Lasoń, Lars-Ove Brandenburg, Marcello Leopoldo, Enza Lacivita, Agnieszka Basta-Kaim
Cells, 1524 10.3390/cells10061524
PMID:34204273

Formyl peptide receptor 2, as an important target for ligands triggering the inflammatory response regulation: a link to brain pathology. Kinga Tylek, Ewa Trojan, Magdalena Regulska, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
Pharmacological reports : PR, 10.1007/s43440-021-00271-x
PMID:34105114

Shedding light on the role of CX3CR1 in the pathogenesis of schizophrenia. Katarzyna Chamera, Magdalena Szuster-Głuszczak, Agnieszka Basta-Kaim
Pharmacological reports : PR, 10.1007/s43440-021-00269-5
PMID:34021899

Role of Polyinosinic:Polycytidylic Acid-Induced Maternal Immune Activation and Subsequent Immune Challenge in the Behaviour and Microglial Cell Trajectory in Adult Offspring: A Study of the Neurodevelopmental Model of Schizophrenia. Katarzyna Chamera, Ewa Trojan, Katarzyna Kotarska, Magdalena Szuster-Głuszczak, Natalia Bryniarska, Kinga Tylek, Agnieszka Basta-Kaim
International journal of molecular sciences, 1558 10.3390/ijms22041558
PMID:33557113

The contribution of formyl peptide receptor dysfunction to the course of neuroinflammation: A potential role in the brain pathology. Ewa Trojan, Natalia Bryniarska, Monika Leśkiewicz, Magdalena Regulska, Katarzyna Chamera, Magdalena Szuster, Marcello Leopoldo, Enza Lacivita, Agnieszka Basta-Kaim
Current neuropharmacology, 10.2174/1570159X17666191019170244
PMID:31629396

The prenatal challenge with lipopolysaccharide and polyinosinic:polycytidylic acid disrupts CX3CL1-CX3CR1 and CD200-CD200R signalling in the brains of male rat offspring: a link to schizophrenia-like behaviours. Katarzyna Chamera, Katarzyna Kotarska, Magdalena Szuster-Głuszczak, Ewa Trojan, Alicja Skórkowska, Bartosz Pomierny, Weronika Krzyżanowska, Natalia Bryniarska, Agnieszka Basta-Kaim
Journal of neuroinflammation, 10.1186/s12974-020-01923-0
PMID:32829711

Maternal Immune Activation Sensitizes Male Offspring Rats to Lipopolysaccharide-Induced Microglial Deficits Involving the Dysfunction of CD200-CD200R and CX3CL1-CX3CR1 Systems. Katarzyna Chamera, Magdalena Szuster-Głuszczak, Ewa Trojan, Agnieszka Basta-Kaim
Cells, E1676 10.3390/cells9071676
PMID:32664639

The Potential Role of Dysfunctions in Neuron - Microglia Communication in the Pathogenesis of Brain Disorders. Katarzyna Chamera, Ewa Trojan, Magdalena Szuster-Głuszczak, Agnieszka Basta-Kaim
Current neuropharmacology, 10.2174/1570159X17666191113101629
PMID:31729301

Inflammatory Consequences of Maternal Diabetes on the Offspring Brain: a Hippocampal Organotypic Culture Study. Katarzyna Głombik, Ewa Trojan, Anna Kurek, Bogusława Budziszewska, Agnieszka Basta-Kaim
Neurotoxicity research, 10.1007/s12640-019-00070-6
PMID:31197747

Interaction of the immune-inflammatory and the kynurenine pathways in rats resistant to antidepressant treatment in model of depression. Weronika Duda, Katarzyna Curzytek, Marta Kubera, Thomas J Connor, Eimear M Fagan, Agnieszka Basta-Kaim, Ewa Trojan, Mariusz Papp, Piotr Gruca, Bogusława Budziszewska, Monika Leśkiewicz, Michael Maes, Władysław Lasoń
International immunopharmacology, S1567-5769(19)31099-9 10.1016/j.intimp.2019.05.039
PMID:31176083

Protective effects of polydatin in free and nanocapsulated form on changes caused by lipopolysaccharide in hippocampal organotypic cultures. Agnieszka Basta-Kaim, Joanna Ślusarczyk, Krzysztof Szczepanowicz, Piotr Warszyński, Monika Leśkiewicz, Magdalena Regulska, Ewa Trojan, Władysław Lasoń
Pharmacological reports : PR, S1734-1140(18)30557-7 10.1016/j.pharep.2019.02.017
PMID:31176102

Role of Chronic Administration of Antidepressant Drugs in the Prenatal Stress-Evoked Inflammatory Response in the Brain of Adult Offspring Rats: Involvement of the NLRP3 Inflammasome-Related Pathway. Ewa Trojan, Katarzyna Chamera, Natalia Bryniarska, Katarzyna Kotarska, Monika Leśkiewicz, Magdalena Regulska, Agnieszka Basta-Kaim
Molecular neurobiology, 10.1007/s12035-018-1458-1
PMID:30610610

Targeting the NLRP3 Inflammasome-Related Pathways via Tianeptine Treatment-Suppressed Microglia Polarization to the M1 Phenotype in Lipopolysaccharide-Stimulated Cultures. Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Anna Piotrowska, Bogusława Budziszewska, Marta Kubera, Katarzyna Popiołek-Barczyk, Władysław Lasoń, Joanna Mika, Agnieszka Basta-Kaim
International journal of molecular sciences, E1965 10.3390/ijms19071965
PMID:29976873

The effect of dermal benzophenone-2 administration on immune system activity, hypothalamic-pituitary-thyroid axis activity and hematological parameters in male Wistar rats. Żaneta Broniowska, Joanna Ślusarczyk, Beata Starek-Świechowicz, Ewa Trojan, Bartosz Pomierny, Weronika Krzyżanowska, Agnieszka Basta-Kaim, Bogusława Budziszewska
Toxicology, S0300-483X(18)30050-7 10.1016/j.tox.2018.04.002
PMID:29660579

Mitochondrial proteomics investigation of frontal cortex in an animal model of depression: Focus on chronic antidepressant drugs treatment. Katarzyna Głombik, Aneta Stachowicz, Ewa Trojan, Joanna Ślusarczyk, Maciej Suski, Katarzyna Chamera, Katarzyna Kotarska, Rafał Olszanecki, Agnieszka Basta-Kaim
Pharmacological reports : PR, S1734-1140(17)30491-7 10.1016/j.pharep.2017.11.016
PMID:29477041

The Modulatory Properties of Chronic Antidepressant Drugs Treatment on the Brain Chemokine - Chemokine Receptor Network: A Molecular Study in an Animal Model of Depression. Ewa Trojan, Joanna Ślusarczyk, Katarzyna Chamera, Katarzyna Kotarska, Katarzyna Głombik, Marta Kubera, Agnieszka Basta-Kaim
Frontiers in pharmacology, 10.3389/fphar.2017.00779
PMID:29163165

Prenatal stress affects viability, activation, and chemokine signaling in astroglial cultures. Joanna E Sowa, Joanna Ślusarczyk, Ewa Trojan, Katarzyna Chamera, Monika Leśkiewicz, Magdalena Regulska, Katarzyna Kotarska, Agnieszka Basta-Kaim
Journal of neuroimmunology, S0165-5728(17)30192-3 10.1016/j.jneuroim.2017.08.006
PMID:28844502

The effects of pessimism on cell-mediated immunity in rats. Katarzyna Curzytek, Marta Kubera, Ewa Trojan, Kinga Wójcik, Agnieszka Basta-Kaim, Jan Detka, Michael Maes, Rafal Rygula
Progress in neuro-psychopharmacology & biological psychiatry, S0278-5846(17)30059-3 10.1016/j.pnpbp.2017.04.034
PMID:28595946

Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria - A proteomic study in an animal model of depression. Katarzyna Głombik, Aneta Stachowicz, Ewa Trojan, Rafał Olszanecki, Joanna Ślusarczyk, Maciej Suski, Katarzyna Chamera, Bogusława Budziszewska, Władysław Lasoń, Agnieszka Basta-Kaim
Progress in neuro-psychopharmacology & biological psychiatry, S0278-5846(17)30045-3 10.1016/j.pnpbp.2017.05.014
PMID:28526399

A Potential Contribution of Chemokine Network Dysfunction to the Depressive Disorders. Joanna Ślusarczyk, Ewa Trojan, Jakub Chwastek, Katarzyna Głombik, Agnieszka Basta-Kaim
Current neuropharmacology,
PMID:26893168

Regulation of insulin receptor phosphorylation in the brains of prenatally stressed rats: New insight into the benefits of antidepressant drug treatment. Katarzyna Głombik, Joanna Ślusarczyk, Ewa Trojan, Katarzyna Chamera, Bogusława Budziszewska, Władysław Lasoń, Agnieszka Basta-Kaim
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, S0924-977X(16)32013-2 10.1016/j.euroneuro.2016.12.005
PMID:28063625

Pro-apoptotic Action of Corticosterone in Hippocampal Organotypic Cultures. Anna Kurek, Mateusz Kucharczyk, Jan Detka, Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Bartosz Bojarski, Agnieszka Ludwikowska, Władysław Lasoń, Bogusława Budziszewska
Neurotoxicity research, 10.1007/s12640-016-9630-8
PMID:27189478

Beneficial impact of intracerebroventricular fractalkine administration on behavioral and biochemical changes induced by prenatal stress in adult rats: Possible role of NLRP3 inflammasome pathway. Joanna Ślusarczyk, Ewa Trojan, Karolina Wydra, Katarzyna Głombik, Katarzyna Chamera, Mateusz Kucharczyk, Bogusława Budziszewska, Marta Kubera, Władysław Lasoń, Małgorzata Filip, Agnieszka Basta-Kaim
Biochemical pharmacology, 10.1016/j.bcp.2016.05.008 S0006-2952(16)30081-8
PMID:27206338

The effect of chronic tianeptine administration on the brain mitochondria: direct links with an animal model of depression. Katarzyna Głombik, Aneta Stachowicz, Rafał Olszanecki, Joanna Ślusarczyk, Ewa Trojan, Władysław Lasoń, Marta Kubera, Bogusława Budziszewska, Michael Spedding, Agnieszka Basta-Kaim
Molecular neurobiology,
PMID:26934888

Immune malfunction in the GPR39 zinc receptor of knockout mice: Its relationship to depressive disorder. Katarzyna Młyniec, Ewa Trojan, Joanna Ślusarczyk, Katarzyna Głombik, Agnieszka Basta-Kaim, Bogusława Budziszewska, Jakub Skrzeszewski, Agata Siwek, Birgitte Holst, Gabriel Nowak
Journal of neuroimmunology, 10.1016/j.jneuroim.2015.12.001 S0165-5728(15)30094-1
PMID:26857489

The Beneficial Impact of Antidepressant Drugs on Prenatal Stress-Evoked Malfunction of the Insulin-Like Growth Factor-1 (IGF-1) Protein Family in the Olfactory Bulbs of Adult Rats. Ewa Trojan, Katarzyna Głombik, Joanna Ślusarczyk, Bogusława Budziszewska, Marta Kubera, Adam Roman, Władysław Lasoń, Agnieszka Basta-Kaim
Neurotoxicity research, 10.1007/s12640-015-9575-3
PMID:26610812

Beneficial properties of maraviroc on neuropathic pain development and opioid effectiveness in rats. Klaudia Kwiatkowski, Anna Piotrowska, Ewelina Rojewska, Wioletta Makuch, Agnieszka Jurga, Joanna Slusarczyk, Ewa Trojan, Agnieszka Basta-Kaim, Joanna Mika
Progress in neuro-psychopharmacology & biological psychiatry, 10.1016/j.pnpbp.2015.07.005 S0278-5846(15)30013-0
PMID:26190414

Maternal stress predicts altered biogenesis and the profile of mitochondrial proteins in the frontal cortex and hippocampus of adult offspring rats. Katarzyna Głombik, Aneta Stachowicz, Joanna Ślusarczyk, Ewa Trojan, Bogusława Budziszewska, Maciej Suski, Marta Kubera, Władysław Lasoń, Krzysztof Wędzony, Rafał Olszanecki, Agnieszka Basta-Kaim
Psychoneuroendocrinology, 10.1016/j.psyneuen.2015.06.015 S0306-4530(15)00230-9
PMID:26143539

Prenatal stress is a vulnerability factor for altered morphology and biological activity of microglia cells. Joanna Ślusarczyk, Ewa Trojan, Katarzyna Głombik, Bogusława Budziszewska, Marta Kubera, Władysław Lasoń, Katarzyna Popiołek-Barczyk, Joanna Mika, Krzysztof Wędzony, Agnieszka Basta-Kaim
Frontiers in cellular neuroscience, 10.3389/fncel.2015.00082
PMID:25814933

Prenatal administration of lipopolysaccharide induces sex-dependent changes in glutamic acid decarboxylase and parvalbumin in the adult rat brain. A Basta-Kaim, K Fijał, J Ślusarczyk, E Trojan, K Głombik, B Budziszewska, M Leśkiewicz, M Regulska, M Kubera, W Lasoń, K Wędzony
Neuroscience, 10.1016/j.neuroscience.2014.12.013 S0306-4522(14)01055-0
PMID:25528062

The impact of prenatal stress on insulin-like growth factor-1 and pro-inflammatory cytokine expression in the brains of adult male rats: the possible role of suppressors of cytokine signaling proteins. Ewa Szczesny, Agnieszka Basta-Kaim, Joanna Slusarczyk, Ewa Trojan, Katarzyna Glombik, Magdalena Regulska, Monika Leskiewicz, Boguslawa Budziszewska, Marta Kubera, Wladyslaw Lason
Journal of neuroimmunology, 10.1016/j.jneuroim.2014.08.001 S0165-5728(14)00234-3
PMID:25151093

Prenatal stress leads to changes in IGF-1 binding proteins network in the hippocampus and frontal cortex of adult male rat. A Basta-Kaim, E Szczesny, K Glombik, J Slusarczyk, E Trojan, K A Tomaszewski, B Budziszewska, M Kubera, W Lason
Neuroscience, 10.1016/j.neuroscience.2014.05.010 S0306-4522(14)00393-5
PMID:24857711

Insights into the Potential Impact of Quetiapine on the Microglial Trajectory and Inflammatory Response in Organotypic Cortical Cultures Derived from Rat Offspring. Katarzyna Chamera, Katarzyna Curzytek, Kinga Kamińska, Ewa Trojan, Monika Leśkiewicz, Kinga Tylek, Magdalena Regulska, Agnieszka Basta-Kaim
,
PMID:37239076

Oxygen-Glucose Deprivation in Organotypic Hippocampal Cultures Leads to Cytoskeleton Rearrangement and Immune Activation: Link to the Potential Pathomechanism of Ischaemic Stroke. Natalia Bryniarska-Kubiak, Andrzej Kubiak, Ewa Trojan, Julita Wesołowska, Małgorzata Lekka, Agnieszka Basta-Kaim
,
PMID:37296586

undefined Ewa Trojan, Katarzyna Curzytek, Paulina Cieślik, Joanna M Wierońska, Johannes Graff, Władysław Lasoń, Takashi Saito, Takaomi C Saido, Agnieszka Basta-Kaim
,
PMID:37422091

Stimulation of Formyl Peptide Receptor-2 by the New Agonist CMC23 Protects against Endotoxin-Induced Neuroinflammatory Response: A Study in Organotypic Hippocampal Cultures. Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Fabio Francavilla, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
,
PMID:37775304

Microglia Depletion Attenuates the Pro-Resolving Activity of the Formyl Peptide Receptor 2 Agonist AMS21 Related to Inhibition of Inflammasome NLRP3 Signalling Pathway: A Study of Organotypic Hippocampal Cultures. Kinga Tylek, Ewa Trojan, Monika Leśkiewicz, Imane Ghafir El Idrissi, Enza Lacivita, Marcello Leopoldo, Agnieszka Basta-Kaim
,
PMID:37947648

Anti-diabetes and neuroprotection potential and primary safety studies of Isatis tinctoria L. hydroalcoholic leaf extract. Noemi Nicosia, Inga Kwiecień, Marek Bednarski, Monika Głuch-Lutwin, Barbara Mordyl, Kamil Mika, Rimma Hambaryan, Anthea Miller, Alessio Alesci, Eugenia R Lauriano, Paula Zammit, Salvatore Ragusa, Ewa Trojan, Angelo Fumia, Jacek Sapa, Natalizia Miceli, Magdalena Kotańska
,
PMID:39053741

Ewa Trojan, PhD

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