Employees - Institute of Pharmacology - Polish Academy of Sciences

Multiple Administration of Endogenous Amines TIQ and 1MeTIQ Protects Against a 6-OHDA-Induced Essential Fall of Dopamine Release in the Rat Striatum: In Vivo Microdialysis Study. Agnieszka Wąsik, Irena Romańska, Agnieszka Zelek-Molik, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-017-9824-8
PMID:29076060

The mechanism of neuroprotective action of natural compounds. Agnieszka Wąsik, Lucyna Antkiewicz-Michaluk
Pharmacological reports : PR, S1734-1140(16)30471-6 10.1016/j.pharep.2017.03.018
PMID:28623709

Antidepressant-Like Effect of the Endogenous Neuroprotective Amine, 1MeTIQ in Clonidine-Induced Depression: Behavioral and Neurochemical Studies in Rats. Lucyna Antkiewicz-Michaluk, Irena Romańska, Agnieszka Wąsik, Jerzy Michaluk
Neurotoxicity research, 10.1007/s12640-017-9715-z
PMID:28367606

Antidepressant-like effect of 1,2,3,4-tetrahydroisoquinoline and its methyl derivative in animal models of depression. Edyta Możdżeń, Agnieszka Wąsik, Irena Romańska, Jerzy Michaluk, Lucyna Antkiewicz-Michaluk
Pharmacological reports : PR, S1734-1140(16)30213-4 10.1016/j.pharep.2017.01.032
PMID:28364697

Comparison of the Effects of Acute and Chronic Administration of Tetrahydroisoquinoline Amines on the In Vivo Dopamine Release: A Microdialysis Study in the Rat Striatum. Agnieszka Wąsik, Irena Romańska, Lucyna Antkiewicz-Michaluk
Neurotoxicity research,
PMID:27568335

The impact of 1MeTIQ on the dopaminergic system function in the 6-OHDA model of Parkinson's disease. Agnieszka Wąsik, Dawid Polak, Irena Romańska, Jerzy Michaluk, Lucyna Antkiewicz-Michaluk
Pharmacological reports : PR, S1734-1140(16)30107-4 10.1016/j.pharep.2016.08.004
PMID:27657483

EFFECTS OF PERINATAL EXPOSURE TO LEAD (Pb) ON PURINE RECEPTOR EXPRESSION IN THE BRAIN AND GLIOSIS IN RATS TOLERANT TO MORPHINE ANALGESIA. Irena Baranowska-Bosiacka, Joanna Listos, Izabela Gutowska, Anna Machoy-Mokrzyńska, Agnieszka Kolasa-Wołosiuk, Maciej Tarnowski, Kamila Puchałowicz, Adam Prokopowicz, Sylwia Talarek, Piotr Listos, Agnieszka Wąsik, Dariusz Chlubek
Toxicology, S0300-483X(15)30044-5 10.1016/j.tox.2015.10.003
PMID:26478469

Neuroprotective Effect of the Endogenous Amine 1MeTIQ in an Animal Model of Parkinson's Disease. Agnieszka Wąsik, Irena Romańska, Jerzy Michaluk, Agnieszka Zelek-Molik, Irena Nalepa, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-015-9556-6
PMID:26303030

Chronic salsolinol administration prevents the behavioral and neurochemical effects of L-DOPA in rats. Agnieszka Wąsik, Irena Romańska, Jerzy Michaluk, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-015-9523-2
PMID:25711629

Salsolinol, an endogenous compound triggers a two-phase opposing action in the central nervous system. Edyta Możdżeń, Małgorzata Kajta, Agnieszka Wąsik, Tomasz Lenda, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-014-9511-y
PMID:25537852

Withdrawal from repeated administration of a low dose of reserpine induced opposing adaptive changes in the noradrenaline and serotonin system function: a behavioral and neurochemical ex vivo and in vivo studies in the rat. Lucyna Antkiewicz-Michaluk, Agnieszka Wąsik, Edyta Możdżeń, Irena Romańska, Jerzy Michaluk
Progress in neuro-psychopharmacology & biological psychiatry, 10.1016/j.pnpbp.2014.10.009 S0278-5846(14)00200-0
PMID:25445479

Antidepressant-like effect of tetrahydroisoquinoline amines in the animal model of depressive disorder induced by repeated administration of a low dose of reserpine: behavioral and neurochemical studies in the rat. Lucyna Antkiewicz-Michaluk, Agnieszka Wąsik, Edyta Możdżeń, Irena Romańska, Jerzy Michaluk
Neurotoxicity research, 10.1007/s12640-013-9454-8
PMID:24407488

1-Benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous neurotoxic compound, disturbs the behavioral and biochemical effects of L-DOPA: in vivo and ex vivo studies in the rat. Agnieszka Wąsik, Irena Romańska, Jerzy Michaluk, Małgorzata Kajta, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-014-9476-x
PMID:24842650

1-Methyl-1,2,3,4-tetrahydroisoquinoline, an endogenous Neuroprotectant and MAO inhibitor with antidepressant-like properties in the rat. Agnieszka Wąsik, Edyta Możdżeń, Jerzy Michaluk, Irena Romańska, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-013-9425-0
PMID:24065621

1,2,3,4-Tetrahydroisoquinoline produces an antidepressant-like effect in the forced swim test and chronic mild stress model of depression in the rat: Neurochemical correlates. Edyta Możdżeń, Mariusz Papp, Piotr Gruca, Agnieszka Wąsik, Irena Romańska, Jerzy Michaluk, Lucyna Antkiewicz-Michaluk
European journal of pharmacology, 10.1016/j.ejphar.2014.01.075 S0014-2999(14)00138-1
PMID:24561050

1-Methyl-1,2,3,4-tetrahydroisoquinoline, an endogenous amine with unexpected mechanism of action: new vistas of therapeutic application. Lucyna Antkiewicz-Michaluk, Agnieszka Wąsik, Jerzy Michaluk
Neurotoxicity research, 10.1007/s12640-013-9402-7
PMID:23719903

Concentration-dependent opposite effects of 1-benzyl-1,2,3,4-tetrahydroisoquinoline on markers of apoptosis: in vitro and ex vivo studies. Agnieszka Wąsik, Małgorzata Kajta, Tomasz Lenda, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-013-9436-x
PMID:24190811

Antidepressant-like activity of the endogenous amine, 1-methyl-1,2,3,4-tetrahydroisoquinoline in the behavioral despair test in the rat, and its neurochemical correlates: a comparison with the classical antidepressant, imipramine. Agnieszka Wąsik, Edyta Możdżeń, Irena Romańska, Jerzy Michaluk, Lucyna Antkiewicz-Michaluk
European journal of pharmacology, 10.1016/j.ejphar.2012.11.063 S0014-2999(12)00995-8
PMID:23246532

Comparative behavioral and neurochemical studies of R- and S-1-methyl-1,2,3,4-tetrahydroisoquinoline stereoisomers in the rat. Agnieszka Wąsik, Irena Romańska, Jerzy Michaluk, Lucyna Antkiewicz-Michaluk
Pharmacological reports : PR,
PMID:23087137

Both stereoselective (R)- and (S)-1-Methyl-1,2,3,4-tetrahydroisoquinoline enantiomers protect striatal terminals against rotenone-induced suppression of dopamine release. Lucyna Antkiewicz-Michaluk, Agnieszka Wąsik, Irena Romańska, Andrzej Bojarski, Jerzy Michaluk
Neurotoxicity research, 10.1007/s12640-010-9228-5
PMID:21069490

Important role of 3-methoxytyramine in the inhibition of cocaine sensitization by 1-methyl-1,2,3,4-tetrahydroisoquinoline: an in vivo microdialysis study. Agnieszka Wąsik, Irena Romańska, Lucyna Antkiewicz-Michaluk
Pharmacological reports : PR,
PMID:21273655

1-Methyl-1,2,3,4-tetrahydroisoquinoline antagonizes a rise in brain dopamine metabolism, glutamate release in frontal cortex and locomotor hyperactivity produced by MK-801 but not the disruptions of prepulse inhibition, and impairment of working memory in rat. Małgorzata Pietraszek, Jerzy Michaluk, Irena Romańska, Agnieszka Wasik, Krystyna Gołembiowska, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-009-9097-y
PMID:19649683

1-Benzyl-1,2,3,4-tetrahydroisoquinoline, an endogenous parkinsonism-inducing toxin, strongly potentiates MAO-dependent dopamine oxidation and impairs dopamine release: ex vivo and in vivo neurochemical studies. Agnieszka Wasik, Irena Romańska, Lucyna Antkiewicz-Michaluk
Neurotoxicity research, 10.1007/s12640-009-9001-9
PMID:19384584

Loss of SHP-1 tyrosine phosphatase expression correlates with the advanced stages of cutaneous T-cell lymphoma. Agnieszka Witkiewicz, Puthiyaveettil Raghunath, Agnieszka Wasik, Jacqueline M Junkins-Hopkins, Dan Jones, Qian Zhang, Niels Odum, Mariusz A Wasik
Human pathology,
PMID:17239936

The mechanism of 1,2,3,4-tetrahydroisoquinolines neuroprotection: the importance of free radicals scavenging properties and inhibition of glutamate-induced excitotoxicity. Lucyna Antkiewicz-Michaluk, Jerzy W Lazarewicz, Antoni Patsenka, Malgorzata Kajta, Elzbieta Zieminska, Elzbieta Salinska, Agnieszka Wasik, Krystyna Golembiowska, Jerzy Vetulani
Journal of neurochemistry,
PMID:16515537

Agnieszka Wąsik, PhD

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