Professor Katarzyna Starowicz - Bubak, PhD
Professor
Department of Neurochemistry
Katarzyna Starowicz
She holds M.Sc. degree from Jagiellonian University in Krakow, Poland and Ph.D. degree from Utrecht University, the Netherlands. She received habilitation in 2013 at the Jagiellonian University Medical College and since 2021 holds an academic rank of Professor of Medicine and Health Sciences.
After receiving PhD degree in Medical Sciences at the University of Utrecht, she started a postdoctoral fellowship at the Institute of Biomolecular Chemistry CNR in Pozzuoli (Naples, Italy) in the Endocannabinoid Research Group headed by prof. Vincenzo Di Marzo. Continuing her interest in the search for effective substances to treat pain, she conducted a study on the role of TRPV1 receptors located in the CNS and their possible involvement in pain and nociception.
After completing a postdoctoral fellowship, in October 2007 she was employed as a Research Associate in the Department of Pain Pharmacology, Institute of Pharmacology Polish Academy of Sciences in Kraków (Poland), headed by prof. Barbara Przewłocka. She continued the study on the role of the endovanilloid and endocannabinoid systems with particular emphasis towards neuropathic pain. Subsequently, her research interests expanded to include the issue of degenerative joint disease (osteoarthritis, OA).
An important research topic, high involvement of young scientists and significant financing of the research by external sources (LIDER NCBiR and SONATA BIS NCN) resulted in her appointment as Head of the Laboratory of Pain Pathophysiology at the Department of Pain Pharmacology (at the Institute of Pharmacology of the Polish Academy of Sciences in Kraków).
With the appointment as the Head of the Department of Neurochemistry in 2017, she proposed a new research direction for the Department, namely combining pain experiences with activity mesolimbic reward system, as well as an indication of the learning mechanism as important element of persistent effects of severe pain. Prof. Starowicz’s group is also engaged in determining the cannabinoid function in chondrocyte regeneration, in determining the inflammatory component in OA as well as in studying the function of cannabinoid receptor ligands in the regulation of chondrocytes and osteoblast activity. In April 2021 President of Poland awarded her with a title of full professor in medicinal and health sciences.
She specializes in the strategies of chronic pain treatment, especially in extending the effectiveness of neuropathic and osteoarthritis pain therapy through targeting the endogenous cannabinoid system.
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CB2 agonism controls pain and subchondral bone degeneration induced by mono-iodoacetate: Implications GPCR functional bias and tolerance development.
Jakub Mlost, Magdalena Kostrzewa, Małgorzata Borczyk, Marta Bryk, Jakub Chwastek, Michał Korostyński, Katarzyna Starowicz
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, S0753-3322(21)00068-8 10.1016/j.biopha.2021.111283
PMID:33482616 -
Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action.
Jakub Mlost, Marta Bryk, Katarzyna Starowicz
International journal of molecular sciences, E8870 10.3390/ijms21228870
PMID:33238607 -
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Claudia Mugnaini, Magdalena Kostrzewa, Marta Bryk, Ali Mokhtar Mahmoud, Antonella Brizzi, Stefania Lamponi, Gianluca Giorgi, Francesca Ferlenghi, Federica Vacondio, Paola Maccioni, Giancarlo Colombo, Marco Mor, Katarzyna Starowicz, Vincenzo Di Marzo, Alessia Ligresti, Federico Corelli
Journal of medicinal chemistry, 10.1021/acs.jmedchem.0c00595
PMID:32515588 -
Role of endocannabinoid system in dopamine signalling within the reward circuits affected by chronic pain.
Jakub Mlost, Agnieszka Wąsik, Katarzyna Starowicz
Pharmacological research, S1043-6618(19)30008-8 10.1016/j.phrs.2019.02.029
PMID:30831242 -
Changes in Monoaminergic Neurotransmission in an Animal Model of Osteoarthritis: The Role of Endocannabinoid Signaling.
Jakub Mlost, Agnieszka Wąsik, Jerzy Tadeusz Michaluk, Lucyna Antkiewicz-Michaluk, Katarzyna Starowicz
Frontiers in molecular neuroscience, 10.3389/fnmol.2018.00466
PMID:30618615
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Cognitive impairment in chronic pain - CBD as the undervalued remedy. - 2022-08-10 - 2026-08-09
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Endocannabinoid regulation of the motivational tone at the mesolimbic system driven by inflammation - 2021-07-08 - 2021-07-07
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- 2018-07-20 - 2019-12-20
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The role of synovial fibroblasts' activity in joint pain in osteoarthritis - 2017-08-03 - 2018-08-02
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The role of spinal TRPV1 vanilloid receptors in the analgesic effects of anandamide in a model of neuropathic pain
HOMING FNP -
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National Science Centre 2016 Award in Life Sciences
2016-10-12 -
L'Oreal Poland for Women in Science
2012-11-22 -
2005-03-08
National
- Laboratorium mikrotomografii, Zakład Komputerowych Systemów Biomedycznych, Uniwersytet Śląski http://prac.us.edu.pl/~xm/?page_id=2
- Zakład Biologii Komórki, Wydział Biochemii Biofizyki i Biotechnologii, Uniwersytet Jagielloński http://www.zbk.wbbib.uj.edu.pl/pl_PL
International
- Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University
- Endocannabinoid Research Group (ERG) http://srva.na.icb.cnr.it/erg/
- School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen