Jan Manuel Rodriguez Parkitna, PhD
Department of Molecular Neuropharmacology
I am a researcher studying molecular mechanisms linking genes and
behavior, particularly in context of reinforcement
learning and addiction.
Effects of L-DOPA on gene expression in the frontal cortex of rats with unilateral lesions of midbrain dopaminergic neurons.
Anna Radlicka, Kinga Kamińska, Malgorzata Borczyk, Marcin Piechota, Michał Korostyński, Joanna Pera, Elżbieta Lorenc-Koci, Jan Rodriguez Parkitna
eNeuro, ENEURO.0234-20.2020 10.1523/ENEURO.0234-20.2020
Loss of mu and delta opioid receptors on neurons expressing dopamine receptor D1 has no effect on reward sensitivity.
Zofia Harda, Jadwiga Spyrka, Kamila Jastrzębska, Łukasz Szumiec, Anna Bryksa, Marta Klimczak, Maria Polaszek, Sławomir Gołda, Joanna Zajdel, Klaudia Misiołek, Anna Błasiak, Jan Rodriguez Parkitna
Neuropharmacology, S0028-3908(20)30375-0 10.1016/j.neuropharm.2020.108307
MicroRNAs are indispensable for the proliferation and differentiation of adult neural progenitor cells in mice.
Yang Xu, Karolina Hajdukiewicz, Anshul Tiwari, Joanna Przybyś, Jan Rodriguez Parkitna, Martin Novak, Ilya A Vinnikov, Günther Schütz, Witold Konopka
Biochemical and biophysical research communications, S0006-291X(20)31361-9 10.1016/j.bbrc.2020.06.143
Sensitivity to negative and positive feedback as a stable and enduring behavioural trait in rats.
Karolina Noworyta-Sokolowska, Anna Kozub, Judyta Jablonska, Jan Rodriguez Parkitna, Robert Drozd, Rafal Rygula
The Fat Mass and Obesity-Associated Protein (FTO) Regulates Locomotor Responses to Novelty via D2R Medium Spiny Neurons.
Johan Ruud, Jens Alber, Anna Tokarska, Linda Engström Ruud, Hendrik Nolte, Nasim Biglari, Rachel Lippert, Änne Lautenschlager, Przemysław E Cieślak, Łukasz Szumiec, Martin E Hess, Hella S Brönneke, Marcus Krüger, Hans Nissbrandt, Tatiana Korotkova, Gilad Silberberg, Jan Rodriguez Parkitna, Jens C Brüning
Cell reports, S2211-1247(19)30657-6 10.1016/j.celrep.2019.05.037
Kappa opioid receptors integrate neuronal signaling involved in social behavior - 2020-06-19 - 2024-06-18
National Science Centre grant OPUS
Beneficial interactions with other members of the same species are an essential part of normal behavior. Social interactions engage multiple neuronal pathways, but as evidence shows their rewarding effects converge in the brain’s reward system. We hypothesize that signaling through kappa opioid receptors in the nucleus accumbens (NAc) plays a key role in this process, and enables normal social behaviors. Specifically, we propose that dynorphin activates kappa opioid receptors located in the NAc presynpatically on oxytocin, dopaminergic and serotonergic neurons. Therefore, dynorphin release triggered by any of the above three neurotransmitters would lead to local inhibition of all three of them. The goal of this project is to test this hypothesis, and thus confirm a mechanism through which kappa opioid receptors in the NAc control social behaviors. To prove the hypothesis we will generate genetically modified mice with selective inactivation of kappa opioid receptors in dopaminergic, serotonergic or oxytocin neurons. We expect that these mutations should enhance rewarding effects of social contact, and block the effects of nalmefene (a partial agonist of kappa opioid receptors) on social conditioned place preference. To confirm that signaling in the NAc is responsible for the observed phenotypes, we will generate mice with deletion of kappa opioid receptors in neurons projecting to the NAc (using rAAV2-Cre). We will also test the phenotype of mice with deletion of the gene encoding the precursors of dynorphins, as it should replicate most of the phenotypes observed with the selective mutations. The major outcome of the project will be the demonstration of a mechanism involved in mediating social reward. This should offer insight into mechanisms that may underlie psychopathologies that are associated with social impairments and a potential target for treatment. Furthermore, a dynorphin-mediated interaction between dopamine and serotonin signaling could be involved in all forms of reward-driven behaviors.
The Jerzy Konorski Team Award for the best study in neurobiology conducted in Poland awarded every year by the Polish Neuroscience Society and Committee of Neurobiology of the Polish Academy of Sciences