Affective Cognitive Neuroscience Laboratory
Affective Cognitive Neuroscience Lab (Department) was established in 2013 as a subdivision of the Department of Behavioural Neuroscience and Drug Development at the Institute of Pharmacology Polish Academy of Sciences. In 2017 the laboratory was associated with the Department of Pharmacology. Our main research activity is aimed at investigating the behavioural, pharmacological, neuroanatomical, and neurochemical correlates of cognitive processing biases in animal models.
Agata Cieślik, PhD
Michał Piksa, PhDc
Ewa Kozela, PhD
Jakub Bilnicki, MSc
alumni:
Magdalena Zaniewska, PhD
Karolina Noworyta, PhD
Ewa Świder, Msc
Robert Drozd PhD
Anna Kozub MSc
Michał Rychlik PhD
Joanna Golebiowska MSc
Karolina Rojek PhD
Jakub Kubik
Arkadiusz Liśkiewicz PhD
Jakub Kręgiel MSc
Justyna Papciak PhD
Marta Lemieszewska PhD
Ewa Szczech
Interesting links:
https://www.youtube.com/watch?v=qXjtMeN0PYE&t=1s&ab_channel=PolskaAkademiaUmiej%C4%99tno%C5%9Bci
https://www.polskieradio.pl/10/5366/Artykul/2693798,Dezinformacja-choroba-XXI-wieku
https://www.wsj.com/articles/for-rats-a-good-tickling-can-change-the-world-1468530323
http://www.usatoday.com/story/news/2015/07/28/hamster-mood-angry-study/30803989/
http://www.wsj.com/articles/for-rats-a-good-tickling-can-change-the-world-1468530323
https://digest.bps.org.uk/2016/06/30/pessimistic-rats-are-extra-sensitive-to-negative-feedback/
https://www.facebook.com/Pracownia-Neurobiologii-Emocji-i-Proces%C3%B3w-Poznawczych-231026933735026
https://www.wiz.pl/19,285.html
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Trait sensitivity to negative feedback determines the effects of chronic stress and chronic mirtazapine treatment on anxiety and stress-coping strategies in rats.
Paulina Surowka, Karolina Noworyta, Agata Cieslik, Rafal Rygula
Psychopharmacology, 10.1007/s00213-022-06273-8
PMID:36352265 -
Trait sensitivity to negative feedback determines the intensity of compulsive alcohol seeking and taking in male rats.
Agata Cieslik, Karolina Noworyta, Rafal Rygula
Journal of psychiatry & neuroscience : JPN, 10.1503/jpn.210220
PMID:35820699 -
Cognitive Processes and Personality Traits Underlying Four Phenotypes of Susceptibility to (Mis)Information.
Michal Piksa, Karolina Noworyta, Jan Piasecki, Pawel Gwiazdzinski, Aleksander B Gundersen, Jonas Kunst, Rafal Rygula
Frontiers in psychiatry, 10.3389/fpsyt.2022.912397
PMID:35782415 -
Neuromolecular Underpinnings of Negative Cognitive Bias in Depression.
Karolina Noworyta, Agata Cieslik, Rafal Rygula
Cells, 3157 10.3390/cells10113157
PMID:34831380 -
Reinforcement-based cognitive biases as vulnerability factors in alcohol addiction: From humans to animal models.
Karolina Noworyta, Agata Cieslik, Rafal Rygula
British journal of pharmacology, 10.1111/bph.15613
PMID:34232505 -
Phenotypes of reinforcement sensitivity as predictors of the response to acute antidepressant treatment in rats.
Karolina Noworyta, Rafal Rygula
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, S0924-977X(20)30988-3 10.1016/j.euroneuro.2020.12.004
PMID:33413909 -
Trait Sensitivity to Negative and Positive Feedback Does Not Interact With the Effects of Acute Antidepressant Treatment on Hedonic Status in Rats.
Paulina Surowka, Karolina Noworyta, Rafal Rygula
Frontiers in behavioral neuroscience, 10.3389/fnbeh.2020.00147
PMID:33061896 -
Chronic Psychosocial Stress Causes Increased Anxiety-Like Behavior and Alters Endocannabinoid Levels in the Brain of C57Bl/6J Mice.
Yvonne Bouter, Magdalena M Brzózka, Rafal Rygula, Franziska Pahlisch, F Markus Leweke, Ursula Havemann-Reinecke, Cathrin Rohleder
Cannabis and cannabinoid research, 10.1089/can.2019.0041
PMID:32322676 -
Sensitivity to negative and positive feedback as a stable and enduring behavioural trait in rats.
Karolina Noworyta-Sokolowska, Anna Kozub, Judyta Jablonska, Jan Rodriguez Parkitna, Robert Drozd, Rafal Rygula
Psychopharmacology, 10.1007/s00213-019-05333-w
PMID:31375849 -
Using rodents to model abnormal sensitivity to feedback in depression.
Rafal Rygula, Karolina Noworyta-Sokolowska, Robert Drozd, Anna Kozub
Neuroscience and biobehavioral reviews, S0149-7634(18)30342-7 10.1016/j.neubiorev.2018.10.008
PMID:30347197 -
Effects of cognitive judgement bias and acute antidepressant treatment on sensitivity to feedback and cognitive flexibility in the rat version of the probabilistic reversal-learning test.
Robert Drozd, Michal Rychlik, Agata Fijalkowska, Rafal Rygula
Behavioural brain research, S0166-4328(18)31081-7 10.1016/j.bbr.2018.10.003
PMID:30292902 -
The trait 'pessimism' does not interact with cognitive flexibility but makes rats more vulnerable to stress-induced motivational deficits: Results from the attentional set-shifting task.
Robert Drozd, Karolina Rojek-Sito, Rafal Rygula
Behavioural brain research, S0166-4328(17)31141-5 10.1016/j.bbr.2017.08.028
PMID:28842268 -
The effects of pessimism on cell-mediated immunity in rats.
Katarzyna Curzytek, Marta Kubera, Ewa Trojan, Kinga Wójcik, Agnieszka Basta-Kaim, Jan Detka, Michael Maes, Rafal Rygula
Progress in neuro-psychopharmacology & biological psychiatry, S0278-5846(17)30059-3 10.1016/j.pnpbp.2017.04.034
PMID:28595946 -
Lesions of the Orbitofrontal but Not Medial Prefrontal Cortex Affect Cognitive Judgment Bias in Rats.
Joanna Golebiowska, Rafal Rygula
Frontiers in behavioral neuroscience, 10.3389/fnbeh.2017.00051
PMID:28377703 -
Effects of acute dopaminergic and serotonergic manipulations in the ACI paradigm depend on the basal valence of cognitive judgement bias in rats.
Joanna Golebiowska, Rafal Rygula
Behavioural brain research, S0166-4328(16)31261-X 10.1016/j.bbr.2017.02.013
PMID:28212943
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Neurobiology of optimism (article in polish)
The article was published in journal "Wszechświat" and is based on a talk given during the 2014 Brain Awarness Week in Krakow.
http://www.ptpk.org/tydzien_mozgu/tydzien_mozgu_2014.html#art_5
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Translational and interdisciplinary investigation of phenotypes of reinforcement sensitivity as predictors of the response to antidepressant treatment, Professor Rafał Ryguła, PhD
Why do antidepressant drugs fail to work in some people suffering from depression, while for others they quickly bring relief of their symptoms? Are the positive outcomes of antidepressant treatment associated with sensitivity to reward and punishment? And if so, could screening of this sensitivity facilitate finding of the right treatment? Although the relationship between reinforcement sensitivity, affective disorders, and effectivity of pharmacological treatment has been widely postulated and brought together through influential theoretical narratives, until now, there has been no systematic study aimed at investigating these interactions. To address this need, in the present project, we will employ a novel animal model linking various levels of sensitivity to reward and punishment with a putative reactivity to antidepressant treatment. We will also compare the obtained results from animals with the data from humans taking antidepressant medications, using the pioneering online techniques and fully translational behavioural tests. Finally, we will verify, compare, and extend the results from animals and humans using computational modelling of behaviour. Based on the proposed experiments we will be able to conduct complex and multilevel verification of the hypothesis that trait sensitivity to reward and punishment (phenotype of reinforcement sensitivity) can determine the interindividual differences in the effectiveness of antidepressant treatment. Obtained results will be used to understand the phenomena of drug resistance and low effectiveness in antidepressant therapy.
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#Webimmunization. How can online social networks create collective resilience against misinformation?”, Professor Rafał Ryguła, PhD
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The role of cognitive bias in individual vulnerability to to the transition from controlled use to uncontrolled abuse of alcohol in an animal model., Professor Rafał Ryguła, PhD
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Neuroscience boat, Professor Rafał Ryguła, PhD
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, Professor Rafał Ryguła, PhD
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Sensitivity to negative feedback as a cognitive biomarker of depression in an animal model, Professor Rafał Ryguła, PhD
Carried out in years 2017 - 2020. Received from Polish National Science Centre as a part of OPUS 12 program. P.I.: Rafal Rygula -
Pessimism as a cognitive biomarker of depressive disorder in an animal model (Grant NCN DEC-2014/13/B/NZ4/00214), Professor Rafał Ryguła, PhD
Research conducted in years 2015-2018. Received within the programme OPUS 7 by the Polish National Centre for Science. P.I.:Rafał Ryguła
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, Professor Rafał Ryguła, PhD
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, Professor Rafał Ryguła, PhD
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, Professor Rafał Ryguła, PhD
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, Adam Roman, PhD
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Translational and interdisciplinary investigation of phenotypes of reinforcement sensitivity as predictors of the response to antidepressant treatment, Professor Rafał Ryguła, PhD
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, Professor Rafał Ryguła, PhD
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, Professor Rafał Ryguła, PhD
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Rafal Rygula: Prime Minister's award for habilitation, Professor Rafał Ryguła, PhD
Thursday, 24 November 2016
interests
techniques
- ambiguous-cue interpretation test
- analysis of ultrasonic vocalisations
- chronic psychosocial stress
- colorometric evaluation of macrophage activity
- HPLC EC
- HPLC UV
- immune cells tissue cultures
- liquid chromatography
- probabilistic reversal learning
- rat Slot Machine Task
- resident intruder paradigm
- reversal learning
- voluntary alcohol drinking
keywords
- 5,7-DHT
- 6-OHDA
- alcohol
- amphetamine
- animal models
- antidepressants
- cognitive neuroscience
- cytokines
- depression
- feedback sensitivity
- immobilization stress
- immune system
- judgment bias
- laughter
- macrophages
- mouse
- probabilistic reversal learning
- psychopharmacology
- psychosocial stress
- rat
- safety signals
- serial reversal learning
- serotonin
- stress
- tickling



