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MINIREVIEW - Alterations in zinc homeostasis in depression and antidepressant therapy. Gabriel Nowak (p. 1) Role of NMDA receptor in the effects of arginine-vasopressin on memory processes. Barbara Artemowicz, Konstanty Wiśniewski (p. 5) Effect of bicuculline and angiotensin II fragment 3-7 on learning and memory processes in rats chronically treated with ethanol. Magdalena Kuziemka-Łęska, Halina Car, Konstanty Wiśniewski (p. 15) Influence of felodipine on experimental seizures and activity of different antiepileptic drugs in mice. Piotr Waciński (p. 23) Electrophysiological investigation of the effects of ambroxol on the transepithelial Na+ ion transport pathway in airways. Tomasz Tyrakowski, Igor Greczko, Andrzej Sedlaczek, Bolesław Banach, Mirosława Bartłomowicz, Małgorzata Wojciechowska, Izabela Binkowska, Hanna Chojnacka (p. 31) Effects of the dihydropyridine calcium antagonist nimodipine on the firing rate of cat visual neurons after systemic administration. Horst J. Koch (p. 39) Concentration of copper and zinc in blood of psoriatic patients treated topically with ointment containing 2-chloroethyl-3-chloropropyl sulfide. Maria Kopff, Piotr Wołkanin, Marek Strzelczyk, Witold Mirosław, Arkadiusz Borkowski, Sławomir Puczkowski (p. 47) SHORT COMMUNICATION Histaminergic and noradrenergic control of cyclic AMP formation in the pineal gland and cerebral cortex of three avian species: cock, duck and goose. Jerzy Z. Nowak, Agata Woldan-Tambor, Jolanta B. Zawilska (p. 55) PRELIMINARY COMMUNICATIONS Effect of EMD 57445, the selective sigma receptor ligand, on the turnover and release of dopamine. Grażyna Skuza, Krystyna Gołembiowska, Krzysztof Wędzony (p. 61) Behavioral activity of angiotensin II after stimulation of L-arginine/nitric oxide pathway in rats. Zdzisław Hoły, Konstanty Wiśniewski (p. 65) Papers of Second Conference on PROGRESS IN ETIOPATHOGENESIS OF SEIZURES (p. 77)

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MINIREVIEW - Methods and data analyses in radioligand-receptor binding: unnecessary transformations may cause biased results. Gabriel Nowak (p. 101) Pharmacological profile of venlafaxine, a new antidepressant, given acutely. Zofia Rogoż, Marta Dziedzicka-Wasylewska, Jerzy Maj (p. 107) Antidepressant-like properties of some serotonin receptor ligands and calcium channel antagonists measured with the forced swimming test in mice. Grażyna Biała (p. 117) Central action of glucagon. Dorota Morawska, Maria Sieklucka-Dziuba, Zdzisław Kleinrok (p. 125) Changes in the gastrointestinal tract, cardiovascular function and some drug metabolizing processes in rats and guinea-pigs intoxicated with aflatoxin B1. Vera Štétinová, Vojtéch Grossman, Jaroslav Kvétina (p. 135) New proctolin analogues and their myotropic effects on heart of yellow mealworm Tenebrio molitor L. and foregut of locust - Schistocerca gregaria L. Mariola Kuczer, Grzegorz Rosiński, Jonathan Issberner, Richard Osborne, Danuta Konopińska (p. 143) Doxorubicin-induced inhibition of prolidase activity in human skin fibroblasts and its implication to impaired collagen biosynthesis. Anna Muszyńska, Jerzy Pałka, Sławomir Wołczyński (p. 151) Abstracts of the SEVENTH DAYS of NEUROPSYCHOPHARMACOLOGY "DECADE of the BRAIN" (p. 161) Book Review. Andrzej Śródka (p. 185)

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Effect of nifedipine and verapamil on hypotensive action of clonidine in rabbits. Elżbieta Czarnecka, Wiesława Tymczyszyn, Bogusława Pietrzak (p. 193) Interaction of cholecystokinin (CCK-33) and its C-terminal fragments: CCK-8 and CCK-4 with alpha- and beta-adrenoceptor agonists and antagonists in the cardiovascular system of rats. Part A. Róża J. Wiśniewska (p. 203) Interaction of cholecystokinin (CCK-33) and its C-terminal fragments: CCK-8 and CCK-4 with alpha- and beta-adrenoceptor agonists and antagonists in the cardiovascular system of rats. Part B. Róża J. Wiśniewska (p. 213) Evaluation of antiarrhythmic activity of captopril and enalaprilat in experimental cardiac arrhythmias in rabbits. Part I. Małgorzata Dzielska-Olczak, Przedzisław Polakowski, Elżbieta Kubik-Bogucka (p. 225) Evaluation of antiarrhythmic activity of captopril and enalaprilat in experimental cardiac arrhythmias in rabbits. Part II. Małgorzata Dzielska-Olczak, Przedzisław Polakowski (p. 233) Ecto-ATPase from rat lymphocytes - in vivo studies on the influence of levamisole. Leszek Purzyc, Ireneusz Całkosiński (p. 239) Effects of pamidronate on the development of changes in bone mechanical properties and bone structure caused by the administration of prednisolone in rats. Jolanta Tkocz-Kwiatkowska, Ilona Kaczmarczyk-Sedlak, Joanna Folwarczna (p. 253) SHORT COMMUNICATIONS Effect of kainic acid and pentetrazole administration on the activity of nitric oxide synthase in the mouse brain. Mirosław Kata, Leokadia Baran, Joanna Siwanowicz, Marta Dziedzicka-Wasylewska (p. 259) BN 52021, PAF-receptor antagonist, improves diminished antioxidant defense system of lungs in experimentally induced haemorrhagic shock. Marzanna Makarewicz-Płońska, Artur Witek, Ryszard Farbiszewski (p. 265) PRELIMINARY COMMUNICATION Morphine reverses the inhibitory effects of repeated saline injections on peritoneal inflammation in mice. Barbara Płytycz, Magdalena Chadzińska, Joanna Mika, Dominika Łabuz, Barbara Przewłocka, Ryszard Przewłocki (p. 271)

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Behavioral studies of the effects of moderate oligemic hypoxia caused by bilateral clamping of carotid arteries in mice. Impairment of spatial working memory. Lucyna Jóźwiak, Maria Sieklucka-Dziuba, Zdzisław Kleinrok (p. 279) Comparison of the effects of low and high concentrations of group I metabotropic receptor agonists on field potentials in the hippocampal CA1 region in vitro. Agnieszka Zahorodna, Agnieszka Pałucha, Maria Bijak (p. 291) N6-2-(4-aminophenyl)ethyladenosine (APNEA), a putative adenosine A3 receptor agonist, enhances methamphetamine-induced dopamine outflow in rat striatum. Krystyna Gołembiowska, Alicja Żylewska (p. 299) Effects of calcium ions and substances affecting Ca2+-related mechanisms on histamine-evoked stimulation of cyclic AMP formation in chick pineal gland. Jolanta B. Zawilska, Agata Woldan-Tambor, Jerzy Z. Nowak (p. 307) Effect of enflurane on selected neuropeptides and marker enzymes in rabbit brain. Krystyna Kmieciak-Kołada, Zygmunt Chmielnicki, Małgorzata Wąs, Małgorzata Huzarska, Ewa Obuchowicz, Zbigniew Śpiewak, Marcin Kamiński, Andrzej Plewka, Anna Dyaczyńska-Herman, Zbigniew S. Herman (p. 315) Terikalant modifies the contractility and effective refractory period of heart muscle: comparative study in rats and guinea pigs. Ivan Kocić (p. 327) 1,4-Benzoxazin-3(4H)-one derivatives and related compounds as 5-HT1A and 5-HT2A receptor ligands; the effect of the terminal amide fragment on the 5-HT1A/5-HT2A affinity and functional activity. Maria J. Mokrosz, Piotr Kowalski, Teresa Kowalska, Zbigniew Majka, Beata Duszyńska, Sijka Charakchieva-Minol, Anna Szaro, Ewa Tatarczyńska, Aleksandra Kłodzińska, Ewa Chojnacka-Wójcik (p. 333) Effect of linking bridge modifications on the 5-HT1A receptor activity of some 4-(omega-benzotriazol-1-yl)alkyl-1-(2-methoxyphenyl)piperazines. Maria H. Paluchowska, Aleksandra Kłodzińska, Ewa Tatarczyńska, Anna Szaro, Ewa Chojnacka-Wójcik (p. 341) SHORT COMMUNICATIONS Anxiolytic- and antidepressant-like effects of an antagonist at glycineB receptors. Edmund Przegaliński, Ewa Tatarczyńska, Ewa Chojnacka-Wójcik (p. 349) Effect of neurosteroids on glutamate binding sites and glutamate uptake in rat hippocampus. Monika Leśkiewicz, Bogusława Budziszewska, Lucylla Jaworska-Feil, Małgorzata Kajta, Władysław Lasoń (p. 355) Influence of bezafibrate on total antioxidant activity of serum and deformability of blood cells in hypercholesterolaemic patients. Lilia Grodzińska, Robert Jachym, Maciej Sławiński, Jadwiga Robak (p. 361) PRELIMINARY COMMUNICATION Strychnine-insensitive glycine/NMDA sites are altered in two stress models of depression. Gabriel Nowak, Grażyna Ossowska, Renata Jopek, Mariusz Papp (p. 365)

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50th anniversary of Polish Journal of Pharmacology. Władysław Lasoń (p. 375) REVIEW - New vistas inimmunopsychopharmacology. Zbigniew S. Herman (p. 377) REVIEW - Normal and pathological distribution of nitric oxide in the cardiovascular system. Tadeusz Malinski (p. 387) REVIEW - Endogenous drug-like factors. Aleksander Mrozikiewicz (p. 393) Effect of local intracerebral administration of EMD 57445, a selective s receptor ligand, on the locomotor activity of the rat. Grażyna Skuza, Waclaw Kolasiewicz, Marta Dziedzicka-Wasylewska, Wojciech Margas (p. 399) Differential effects of intrathecally and intracerebroventricularly administered nitric oxide donors on noxious mechanical and thermal stimulation. Halina Machelska, Ryszard Przewłocki, Marek W. Radomski, Barbara Przewłocka (p. 407) Modulation of neutrophil activity by submandibular gland peptide-T (SGP-T). Makela Nkemdirim, Marta Kubera, Ronald Mathison (p. 417) Postmortem instability of dopamine and its metabolites in rat striatum and limbic forebrain. Beata Karolewicz, Irena Romańska, Lucyna Antkiewicz-Michaluk (p. 425) Pharmacokinetics of phenothiazine neuroleptics after chronic coadministration of carbamazepine. Władysława A. Daniel, Maciej Syrek, Anna Haduch, Jacek Wójcikowski (p. 431) SHORT COMMUNICATION Reserpine induces increase in neuropeptide Y immunoreactivity in rat amygdala neurons. Maria Śmiałowska, Marta Bajkowska (p. 443) PRELIMINARY COMMUNICATIONS Opposite effects of inhibitory and excitatory neurosteroids on [3H]dopamine release from rat nucleus accumbens. Lucylla Jaworska-Feil, Bogusława Budziszewska, Monika Leśkiewicz, Władysław Lasoń (p. 449) Mechanical reactivity of isolated human and guinea-pig portal veins to spasmogens. Kohsuke Uchida, Atsushi Sakuma, Hiroaki Kogure, Yasuo Ohno, Yuichiro Kamikawa (p. 453)