Copyright © 1998 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 1998, 50, 61-64
ISSN 1230-6002
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PRELIMINARY COMMUNICATION
 EFFECT OF EMD 57445, THE SELECTIVE SIGMA RECEPTOR LIGAND, ON THE TURNOVER AND RELEASE OF DOPAMINE
 Grażyna Skuza#, Krystyna Gołembiowska, Krzysztof Wędzony
 Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland

Effect of EMD 57445, the selective sigma receptor ligand, on the turnover and release of dopamine. G. SKUZA, K. GOŁEMBIOWSKA, K. WĘDZONY. Pol. J. Pharmacol., 1998, 50, 61-64.

EMD 57445 (1, 3 and 10 mg/kg, po), a selective sigma receptor ligand without any affinity to dopamine receptors, induced potent, dose-dependent increases in the tissue DOPAC and HVA levels in the rat brain cortex, nucleus accumbens and striatum. The extracellular DOPAC and HVA levels after EMD 57445 (3 and 10 mg/kg, po) administrations, measured by microdialysis in the rat prefrontal cortex, were also increased, without significant effects on the outflow of dopamine.

Key words: EMD 57445, sigma receptors, dopamine, DOPAC, HVA, tissue levels, microdialysis, rat brain structures
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