Copyright © 1998 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 1998, 50, 135-141
ISSN 1230-6002
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CHANGES IN THE GASTROINTESTINAL TRACT, CARDIOVASCULAR FUNCTION AND SOME DRUG METABOLIZING PROCESSES IN RATS AND GUINEA-PIGS INTOXICATED WITH AFLATOXIN B1
 Věra Štětinová#, Vojtěch Grossmann, Jaroslav Květina
 Institute of Experimental Biopharmaceutics, Joint Laboratories of the Academy of Sciences of the Czech Republic and PRO.MED.CS Praha a.s., Heyrovského 1207, Hradec Králové 500 02, Czech Republic

Changes in the gastrointestinal tract, cardiovascular function and some drug metabolizing processes in rats and guinea-pigs intoxicated with aflatoxin B1. V. ŠTĚTINOVÁ, V. GROSSMANN, J. KVĚTINA. Pol. J. Pharmacol., 1998, 50, 135-141.

The effects of aflatoxin B1 (AFB1) on the reactivity of the peripheral vessels, passage through the gastrointestinal system, production of hydrochloric acid and some liver functions were analyzed. The results shown the decreased glucuronidizing ability of the liver (58% of the initial value) accompanied by an increased amount of the unconjugated substrate while glycine conjugation was not changed in animals on the 3rd day after the treatment with AFB1. The uptake of 99mTc-SnO2 colloid was 1.14 times lower in the liver and 1.94 times higher in the spleen in AFB1 treated animals. A lowered activity of the glucuronizing system and a possibly indirectly lowered uptake of tin colloid in the liver indicate the toxic effect of AFB1 in hepatocytes. The other parameters studied were not changed or were changed only slightly.

Key words: aflatoxin B1, rat, liver, gastrointestinal tract, cardiovascular system
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