Copyright © 1998 by Institute of Pharmacology
Polish Academy of Sciences 		Pol. J. Pharmacol., 1998, 50, 365-369
ISSN 1230-6002
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PRELIMINARY COMMUNICATION
 STRYCHNINE-INSENSITIVE GLYCINE/NMDA SITES ARE ALTERED IN TWO STRESS MODELS OF DEPRESSION
 Gabriel Nowak1#, Grażyna Ossowska2, Renata Jopek1, Mariusz Papp1
 1 Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland,
2 Department of Clinical Pharmacology, Medical University School, Jaczewskiego 8, PL 20-090 Lublin, Poland

Strychnine-insensitive glycine/NMDA sites are altered in two stress models of depression. G. NOWAK, G. OSSOWSKA, R. JOPEK, M. PAPP. Pol. J. Pharmacol., 1998, 50, 365-369.

Chronic severe stress (CSS) and chronic mild stress (CMS) affect the properties of [3H]5,7-dichlorokynurenic acid (5,7-DCKA) binding to strychnine-insensitive glycine/NMDA sites in the rat cerebral cortex. Specifically, CSS decreases, while CMS increases, the potency of glycine to displace [3H]5,7-DCKA binding to glycine/NMDA sites. Moreover, in both models, a reduction of the specific [3H]5,7-DCKA binding was observed. The present results demonstrate the involvement of the cortical NMDA receptor complex in the animal models of depression.

Key words: models of depression, glycine/NMDA sites, radioligand binding
  # correspondence
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