|
Copyright © 1998 by Institute of Pharmacology Polish Academy of Sciences |
Pol. J. Pharmacol., 1998, 50, 361-364 ISSN 1230-6002 |
|
Influence of bezafibrate on total antioxidant activity of serum and deformability of blood cells in hypercholesterolaemic patients.
L. GRODZIŃSKA, R. JACHYM, M. SŁAWIŃSKI, J. ROBAK. Pol. J. Pharmacol. 1998, 50, 361-364. Fourteen patients with hypercholesterolaemia were treated with bezafibrate (600 mg/day) for a month. Before and after the treatment some biochemical and physical parameters were investigated. Plasma cholesterol levels, elevated before treatment, significantly decreased after one month (p < 0.001). Deformability of red blood cells increased significantly in this time (p < 0.05). Total antioxidant status of serum decreased statistically significantly (p < 0.01). It is concluded that the mechanism of action of bezafibrate is not connected with resistance to oxygen free radicals since the drug has no antioxidant activity. A main mechanism of action of bezafibrate seems to be lowering the cholesterol level. An increase in deformability of red blood cells may make some contribution to this mechanism. Key words: bezafibrate, total antioxidant status, red blood cell deformability, cholesterol |
| Back to: Top | PJP - Home Page | |